Alteration in expression and methylation of IGF2/H19 in placenta and umbilical cord blood are associated with macrosomia exposed to intrauterine hyperglycemia

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Su, Rina ^a   Wang, Chen ^a   Feng, Hui ^a   Lin, Li ^a   Liu, Xinyue ^b   Wei, Yumei ^a   Yang, Huixia ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN B; H19 LONG NON-CODING RNA; IGF2 PROTEIN, HUMAN; LONG UNTRANSLATED RNA;

ADULT; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE ACTIVITY; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; H19 GENE; HUMAN; HUMAN TISSUE; INFANT; MACROSOMIA; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; PLACENTA; PREGNANCY DIABETES MELLITUS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION; UMBILICAL CORD BLOOD; BIOSYNTHESIS; CLINICAL TRIAL; DNA METHYLATION; FETUS BLOOD; HYPERGLYCEMIA; METABOLISM; PATHOLOGY; PREGNANCY; UMBILICAL CORD;

ADULT; DIABETES, GESTATIONAL; DNA METHYLATION; FEMALE; FETAL BLOOD; FETAL MACROSOMIA; HUMANS; HYPERGLYCEMIA; INSULIN-LIKE GROWTH FACTOR II; PLACENTA; PREGNANCY; RNA, LONG NONCODING; UMBILICAL CORD;

EID: 84959019785     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148399     Document Type: Article

References (33)

1. Zhu WW, Yang HX, Wei YM, Yan J, Wang ZL, Li XL, et al. Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in china.Diabetes Care. 2013; 6:586-90.
2. Mpondo BC, Ernest A, Dee HE.Gestational diabetes mellitus: challenges in diagnosis and management. J Diabetes Metab Disord. 2015; 12;14:42.
3. Franks PW, Looker HC, Kobes S, Touger L, Tataranni PA, Hanson RL,et al. Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes, 2006; 55: 460-465. PMID: 16443781
4. Manderson JG, Mullan B, Patterson CC, Hadden DR, Traub AI, McCance DR.Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy. Diabetologia,2002; 45: 991-996. PMID: 12136397
5. Parretti E, Mecacci F, Papini M, Cioni R, Carignani L, Mignosa M, La Torre P, et al.Third-trimester maternal glucose levels from diurnal profiles in nondiabetic pregnancies: correlation with sonographic parameters of fetal growth.Diabetes Care, 2001; 24:1319-23. PMID: 11473063
6. Suliman SG, Stanik J, McCulloch LJ, Wilson N, Edghill EL, Misovicova N, et al.Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.Diabetes. 2009; 8:2954-2961.
7. Chatterjee A, Eccles MR. DNA methylation and epigenomics: new technologies and emerging concepts. Genome Biol. 2015; 16:103. doi: 10.1186/s13059-015-0674-5 PMID: 25990550
8. Burris HH, Braun JM, Byun HM, Tarantini L, Mercado A, Wright RJ, et al. Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu. Epigenomics. 2013; 5:271-81. doi: 10.2217/epi.13.24 PMID: 23750643
9. Allard C, Desgagné V, Patenaude J, Lacroix M, Guillemette L, Battista MC, et al.Mendelian randomization supports causality between maternal hyperglycemia and epigenetic regulation of leptin gene in newborns.Epigenetics. 2015; 10:342-351. doi: 10.1080/15592294.2015.1029700 PMID: 25800063
10. Constância M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature. 2002; 417:945-948. PMID: 12087403
11. Waterland RA, Jirtle RL: Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 2004; 20:63-68. PMID: 14698016
12. Bell AC, Felsenfeld G. Methylation of a CTCF-dependent boundary controls imprinted expres sion of the Igf2 gene. Nature 2000; 405:482-485. PMID: 10839546
13. Tobi EW, Heijmans BT, Kremer D, Putter H, de Waal HA D-v, Finken MJ, Wit JM, Slagboom PE: DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics 2011; 6:171-176. PMID: 20930547
14. Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, et al. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes. 2012; 61:1133-1142. doi: 10.2337/db11-1314 PMID: 22447856
15. Xie T, Chen M, Gavrilova O, Lai EW, Liu J, Weinstein LS.Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.Endocrinology. 2008; 149:2443-2450. doi: 10.1210/en.2007-1458 PMID: 18202131
16. Claycombe KJ, Uthus EO, Roemmich JN, Johnson LK, Johnson WT. Prenatal low-protein and postnatal high-fat diets induce rapid adipose tissue growth by inducing Igf2 expression in Sprague Dawley rat offspring. J Nutr. 2013; 143:1533-1539. doi: 10.3945/jn.113.178038 PMID: 23946348
17. Yang HX.Diagnostic criteria for gestational diabetes mellitus (WS 331-2011).Chin Med J (Engl). 2012; 125:1212-1213.
18. Zhang S, Zhai G, Wang J, Shi W, Zhang R, Chen C. IGF-II expression and methylation in small for gestational age infants. J Pediatr Endocrinol Metab. 2015; 28:613-618. doi: 10.1515/jpem-2014-0269 PMID: 25503665
19. LaRocca J, Binder AM, McElrath TF, Michels KB. The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes. Environ Res. 2014; 133:396-406. doi: 10.1016/j.envres.2014.04.032 PMID: 24972507
20. Algar EM, St Heaps L, Darmanian A, Dagar V, Prawitt D, Peters GB,et al. Paternally inherited submicroscopic duplication at 11p15.5 implicates insulin-like growth factor II in overgrowth and Wilms' tumorigenesis. Cancer Res. 2007; 67:2360-2365. PMID: 17325026
21. Court F, Martin-Trujillo A, Romanelli V, Garin I, Iglesias-Platas I, Salafsky I, et al.Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes.Hum Mutat. 2013; 34:595-602. doi: 10.1002/humu.22276 PMID: 23335487
22. St-Pierre J, Hivert MF, Perron P, Poirier P, Guay SP, Brisson D, et al. IGF2 DNA methylation is a modulator of newborn's fetal growth and development. Epigenetics. 2012; 7:1125-1132. doi: 10.4161/epi. 21855 PMID: 22907587
23. Hoyo C, Fortner K, Murtha AP, Schildkraut JM, Soubry A, Demark-Wahnefried W, et al. Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. Cancer Causes Control. 2012; 23:635-645. doi: 10.1007/s10552-012-9932-y PMID: 22392079
24. Perkins E, Murphy SK, Murtha AP, Schildkraut J, Jirtle RL, Demark-Wahnefried W, et al. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J Pediatr. 2012; 161:31-39. doi: 10.1016/j.jpeds.2012.01.015 PMID: 22341586
25. Huang RC, Galati JC, Burrows S, Beilin LJ, Li X, Pennell CE, et al. DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults. Clin Epigenetics.2012; 4:21. doi: 10.1186/1868-7083-4-21 PMID: 23148549
26. Chen Danqing, Zhang Aiping, Fang Min, Fang Rong, Ge Jiamei, Jiang Yuan, et al. Increased methylation at differentially methylated region of GNAS in infants born to gestational diabetes. BMC Medical Genetics 2014; 15:108. doi: 10.1186/s12881-014-0108-3 PMID: 25269528
27. Koukoura O, Sifakis S, Soufla G, Zaravinos A, Apostolidou S, Jones A, et al. Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. Int J Mol Med. 2011; 28:481-7 doi: 10.3892/ijmm.2011.754 PMID: 21805044
28. Sireesha M, Sambasivan V, Kumar VK, Radha S, Raj AY, Qurratulain H. Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair. J Diabetes. 2009; 1:118-24. doi: 10.1111/j.1753-0407.2009.00025.x PMID: 20929508
29. Petry CJ, Seear RV, Wingate DL, Manico L, Acerini CL, Ong KK, et al. Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy. Diabetes. 2011; 60:3090-3096. doi: 10.2337/db11-0689 PMID: 21926269
30. Shao WJ, Tao LY, Gao C, Xie JY, Zhao RQ. Alterations in methylation andexpression levels of imprinted genes H19 and Igf2 in the fetuses ofdiabetic mice. Comp Med 2008; 58:341-346. PMID: 18724775
31. Ornoy A, Reece EA, Pavlinkova G, Kappen C, Miller RK.Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res C Embryo Today. 2015; 105:53-72. doi: 10.1002/bdrc.21090 PMID: 25783684
32. Ideraabdullah FY, Thorvaldsen JL, Myers JA, Bartolomei MS. Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Hum Mol Genet. 2014; 23:6246-6259. doi: 10.1093/hmg/ddu344 PMID: 24990148
33. Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, et al. Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring. Hum Mol Genet. 2015; 24:3021-3029. doi: 10.1093/hmg/ddv013 PMID: 25634562