SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Oliveira, Tales Lyra ^a,b   Candeia Medeiros, Návylla ^a   Cavalcante Araújo, Polliane M ^a   Melo, Igor Santana ^a   Fávaro Pípi, Elaine ^c   Fátima, Luciana Alves ^d   Rocha, Antônio Augusto ^b   Goulart, Luiz Ricardo ^c,e   Machado, Ubiratan Fabres ^d   Campos, Ruy R ^b   Sabino Silva, Robinson ^d  

^a FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOXAN; BRONCHODILATING AGENT; GLUCOSE; ISOPRENALINE; PHLORIZIN; SLC5A1 PROTEIN, RAT; SODIUM GLUCOSE COTRANSPORTER 1;

AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BACTERIAL COUNT; BACTERIAL PNEUMONIA; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LUNG; LUNG ALVEOLUS EPITHELIUM CELL; MALE; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; PATHOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RAT; STAPHYLOCOCCUS INFECTION; WISTAR RAT;

ALLOXAN; ALVEOLAR EPITHELIAL CELLS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHODILATOR AGENTS; COLONY COUNT, MICROBIAL; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; GLUCOSE; ISOPROTERENOL; LUNG; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PHLORHIZIN; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RATS; RATS, WISTAR; SODIUM-GLUCOSE TRANSPORTER 1; STAPHYLOCOCCAL INFECTIONS;

EID: 84959010971     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21752     Document Type: Article

References (42)

1. Pezzulo, A. A. et al. Glucose depletion in the airway surface liquid is essential for sterility of the airways. PLoS One 6, e16166, doi:10.1371/journal.pone.0016166 (2011).
2. Widdicombe, J. H. & Widdicombe, J. G. Regulation of human airway surface liquid. Respir Physiol 99, 3-12 (1995).
3. Baker, E. H. et al. Hyperglycaemia and pulmonary infection. Proc Nutr Soc 65, 227-235 (2006).
4. Baker, E. H. et al. Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis. J Appl Physiol (1985) 102, 1969-1975, doi:10.1152/japplphysiol.01425.2006 (2007).
5. Saumon, G., Martet, G. & Loiseau, P. Glucose transport and equilibrium across alveolar-airway barrier of rat. Am J Physiol 270, L183-190 (1996).
6. Garnett, J. P. et al. Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid. J Immunol 189, 373-380, doi:10.4049/jimmunol.1200718 (2012).
7. Garnett, J. P., Baker, E. H. & Baines, D. L. Sweet talk: insights into the nature and importance of glucose transport in lung epithelium. Eur Respir J 40, 1269-1276, doi:10.1183/09031936.00052612 (2012).
8. Kalsi, K. K. et al. Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism. Pflugers Arch 457, 1061-1070, doi:10.1007/s00424-008-0576-4 (2009).
9. de Prost, N. & Saumon, G. Glucose transport in the lung and its role in liquid movement. Respir Physiol Neurobiol 159, 331-337, doi:10.1016/j.resp.2007.02.014 (2007).
10. Ishikawa, N., Oguri, T., Isobe, T., Fujitaka, K. & Kohno, N. SGLT gene expression in primary lung cancers and their metastatic lesions. Jpn J Cancer Res 92, 874-879 (2001).
11. Ron, I. G., Amir, G., Marmur, S., Chaitchik, S. & Inbar, M. J. Kaposi's sarcoma on a lymphedematous arm after mastectomy. Am J Clin Oncol 19, 87-90 (1996).
12. Vrhovac, I. et al. Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflugers Arch, doi:10.1007/s00424-014-1619-7 (2014).
13. +-glucose cotransporter in type I alveolar epithelium. Histochem Cell Biol 134, 129-136, doi:10.1007/s00418-010-0725-7 (2010).
14. Boyd, C. A. R. Cellular basis of active D-glucose transport in mouse and rabbit lung. Journal of Physiology 422, 44P (1990).
15. Basset, G., Crone, C. & Saumon, G. Fluid absorption by rat lung in situ: pathways for sodium entry in the luminal membrane of alveolar epithelium. J Physiol 384, 325-345 (1987).
16. Garnett, J. P. et al. Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose. Thorax 68, 835-845, doi:10.1136/thoraxjnl-2012-203178 (2013).
17. Garnett, J. P. et al. Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth. PLoS One 8, e76283, doi:10.1371/journal.pone.0076283 (2013).
18. Baker, E. H. et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 61, 284-289, doi:10.1136/thx.2005.051029 (2006).
19. Philips, B. J. et al. Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients. Thorax 60, 761-764, doi:10.1136/thx.2004.035766 (2005).
20. Morgan, S. J. et al. β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent. J Biol Chem 289, 23065-23074, doi:10.1074/jbc.M114.557652 (2014).
21. +/glucose cotransporter expression by protein kinases in Xenopus laevis oocytes. J Biol Chem 271, 14740-14746 (1996).
22. Ishikawa, Y., Eguchi, T. & Ishida, H. Mechanism of beta-adrenergic agonist-induced transmural transport of glucose in rat small intestine. Regulation of phosphorylation of SGLT1 controls the function. Biochim Biophys Acta 1357, 306-318 (1997).
23. Sabino-Silva, R. et al. SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats. Am J Physiol Endocrinol Metab 299, E1028-1037, doi:10.1152/ajpendo.00395.2010 (2010).
24. Aschenbach, J. R., Borau, T. & Gäbel, G. Glucose uptake via SGLT-1 is stimulated by beta(2)-adrenoceptors in the ruminal epithelium of sheep. J Nutr 132, 1254-1257 (2002).
25. Sabino-Silva, R. et al. Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats. Diabetol Metab Syndr 5, 64, doi:10.1186/1758-5996-5-64 (2013).
26. Raja, M. & Kinne, R. K. Identification of phlorizin binding domains in sodium-glucose cotransporter family: SGLT1 as a unique model system. Biochimie 115, 187-193, doi:10.1016/j.biochi.2015.06.003 (2015).
27. Tyagi, N. K. et al. D-Glucose-recognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study. Biochemistry 46, 13616-13628, doi:10.1021/bi701193x (2007).
28. Wright, E. M., Loo, D. D. & Hirayama, B. A. Biology of human sodium glucose transporters. Physiol Rev 91, 733-794, doi:10.1152/physrev.00055.2009 (2011).
29. +-glucose cotransporter is a molecular water pump. J Physiol 508 ( Pt 1), 15-21 (1998).
30. +-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. J Membr Biol 228, 63-69, doi:10.1007/s00232-009-9159-3 (2009).
31. Philips, B. J., Meguer, J. X., Redman, J. & Baker, E. H. Factors determining the appearance of glucose in upper and lower respiratory tract secretions. Intensive Care Med 29, 2204-2210, doi:10.1007/s00134-003-1961-2 (2003).
32. McAlister, F. A. et al. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care 28, 810-815 (2005).
33. Machado, U. F. & Corrêa-Giannella, M. L. Sodium-glucose transporter 2 inhibitors in type 2 diabetes mellitus: navigating between Scylla and Charybdis. Expert Opin Emerg Drugs 19, 5-9, doi:10.1517/14728214.2014.875530 (2014).
34. Polidori, D. et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care 36, 2154-2161, doi:10.2337/dc12-2391 (2013).
35. Powell, D. R. et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. J Pharmacol Exp Ther 345, 250-259, doi:10.1124/jpet.113.203364 (2013).
36. Alves-Wagner, A. B., Sabino-Silva, R., Campello, R. S., Mori, R. C. & Machado, U. F. Decreased diabetes-induced glycemic impairment in WKY and SHR involves enhanced skeletal muscle Slc2a4/GLUT4 expression. Diabetol Metab Syndr 6, 97, doi:10.1186/1758-5996-6-97 (2014).
37. Matsuyama, H. et al. Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study. Respir Res 9, 79, doi:10.1186/1465-9921-9-79 (2008).
38. Ma, G. et al. Increased reabsorption of alveolar edema fluid in the obese Zucker rat. Tohoku J Exp Med 216, 223-230 (2008).
39. Medeiros, I. L. et al. Comparison of lung preservation solutions in human lungs using an ex vivo lung perfusion experimental model. Clinics (Sao Paulo) 67, 1101-1106 (2012).
40. A'Court, C. H. et al. Microbiological lung surveillance in mechanically ventilated patients, using non-directed bronchial lavage and quantitative culture. Q J Med 86, 635-648 (1993).
41. Birkun, A. A. et al. Joint Intratracheal Surfactant-Antibacterial Therapy in Experimental Pseudomonas-Induced Pneumonia. J Aerosol Med Pulm Drug Deliv 28, 299-307, doi:10.1089/jamp.2014.1161 (2015).
42. Chlup, R. et al. Effective assessment of diabetes control using personal glucometers (CONTOURLINK, Bayer, Germany; CALLA, Wellion, Austria; LINUS, Agamatrix, USA). Dis Markers 35, 895-905 (2013).