Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats

Diabetology and Metabolic Syndrome

Volumn 5, Issue 1, 2013, Pages

  Sabino Silva, Robinson ^a,b,c   Okamoto, Maristela Mitiko ^b   David Silva, Aline ^b   Mori, Rosana Cristina ^b   Freitas, Helayne Soares ^b   Machado, Ubiratan Fabres ^b  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

Author keywords

Glucose reabsorption; Parotid; Salivary secretion; Submandibular; Xerostomia

Indexed keywords

PROPRANOLOL; SODIUM GLUCOSE COTRANSPORTER 1;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; HYPERTENSION; HYPOSALIVATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PAROTID GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SALIVARY GLAND; SALIVATION; SUBMANDIBULAR GLAND; SYMPATHETIC TONE; WATER ABSORPTION;

EID: 84886015132     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-5-64     Document Type: Article

References (18)

1. Oral health and salivary composition in diabetic patients. Ben-Aryeh H, Serouya R, Kanter Y, Szargel R, Laufer D, J Diabetes Complications 1993 7 57 62 10.1016/1056-8727(93)90025-T 8481552 (Pubitemid 24009486)
2. Parotid salivary secretion in diabetic autonomic neuropathy. Newrick PG, Bowman C, Green D, O'Brien IA, Porter SR, Scuy C, Corrall RJ, J Diabetes Complications 1991 1991 5 35 37
3. Studies on salivary flow in borderline hypertension. Rahn KH, Van Baak M, Van Hoof M, Schol M, J Hypertens 1983 1 77 78 6681028 (Pubitemid 14186130)
4. Nerve interactions in salivary glands. Emmelin N, J Dent Res 1987 66 509 517 10.1177/00220345870660022101 3305629
5. Excretion of sodium, potassium, chloride and carbon dioxide in human parotid saliva. Thaysen JH, Thorn NA, Schwartz IL, Am J Physiol 1954 178 155 159 13180731
6. Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo. Gresz V, Kwon T, Gong H, Agre P, Steward MC, King LS, Nielsen S, Am J Physiol Gastrointest Liver Physiol 2004 287 151 161 10.1152/ajpgi.00480.2003 (Pubitemid 38802129)
7. Biology of human sodium glucose transporters. Wright EM, Loo DD, Hirayama BA, Physiol Rev 2011 91 733 794 10.1152/physrev.00055.2009 21527736
8. Water pumps. Loo DD, Wright EM, Zeuthen T, J Physiol 2002 542 53 60 10.1113/jphysiol.2002.018713 12096049 (Pubitemid 35190271)
9. Amino acid sequence and the cellular location of the Na (+)-dependent D-glucose symporters (SGLT1) in the ovine enterocyte and the parotid acinar cell. Tarpey PS, Wood IS, Shirazi-Beechey SP, Beechey RB, Biochem J 1995 312 293 300 7492327
10. SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats. Sabino-Silva R, Alves-Vagner ABT, Burgi K, Okamoto MM, Alves AS, Lima GA, Freitas HS, Antunes VR, Machado UF, Am J Physiol Endocrinol Metab 2010 299 1028 1037 10.1152/ajpendo.00395.2010
11. Revised immunolocalization of the Na + -D-glucose cotransporter SGLT1 in rat organs with an improved antibody. Balen D, Ljubojevic M, Breljak D, Brzica H, Zlender V, Koepsell H, Sabolic I, Am J Physiol Cell Physiol 2008 295 475 489
12. Na + -glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. Sabino-Silva R, Freitas HS, Lamers ML, Okamoto MM, Santos MF, Machado UF, J Memb Biol 2009 228 63 69 10.1007/s00232-009-9159-3
13. Glucose sensing in the intestinal epithelium. Dyer J, Vayro S, King TP, Shirazi-Beechey SP, Eur J Biochem 2003 270 3377 3388 10.1046/j.1432-1033.2003. 03721.x 12899695 (Pubitemid 37011630)
14. T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP, Proc Natl Acad Sci U S A 2007 104 15075 15080 10.1073/pnas.0706678104 17724332 (Pubitemid 47619595)
15. Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system. Höfer D, Drenckhahn D, Histochem Cell Biol 1998 110 303 309 10.1007/s004180050292 9749964 (Pubitemid 28401738)
16. Micropuncture and microperfusion study of glucose excretion in rat parotid saliva. Mangos JA, Maragos N, McSherry NR, Am J Physiol 1973 224 1260 1264 26 4712136
17. Salivary composition in diabetic patients. Sharon A, Ben-Aryeh H, Itzhak B, Yoram K, Szargel R, Gutman D, J Oral Med 1985 40 23 26 3855982
18. SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta. Freitas HS, Schaan BD, David-Silva A, Sabino-Silva R, Okamoto MM, Alves-Wagner AB, Mori RC, Machado UF, Mol Cell Endocrinol 2009 305 63 70 10.1016/j.mce.2009.02.014 19433262