-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013;62:112-20.
-
(2013)
Gut
, vol.62
, pp. 112-120
-
-
Jacobetz, M.A.1
Chan, D.S.2
Neesse, A.3
Bapiro, T.E.4
Cook, N.5
Frese, K.K.6
-
4
-
-
79955828776
-
Stromal biology and therapy in pancreatic cancer
-
Neesse A, Michl P, Frese KK, Feig C, Cook N, Jacobetz MA, et al. Stromal biology and therapy in pancreatic cancer. Gut 2011;60:861-8.
-
(2011)
Gut
, vol.60
, pp. 861-868
-
-
Neesse, A.1
Michl, P.2
Frese, K.K.3
Feig, C.4
Cook, N.5
Jacobetz, M.A.6
-
5
-
-
67149143399
-
Inhibition ofHedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition ofHedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
6
-
-
84904244854
-
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure
-
Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, et al. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell 2014;26:14-5.
-
(2014)
Cancer Cell
, vol.26
, pp. 14-15
-
-
Chauhan, V.P.1
Boucher, Y.2
Ferrone, C.R.3
Roberge, S.4
Martin, J.D.5
Stylianopoulos, T.6
-
7
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21:418-29.
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
Cuevas, C.2
Chang, A.E.3
Goel, V.K.4
Von Hoff, D.D.5
Hingorani, S.R.6
-
8
-
-
34248141223
-
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
-
Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 2007;6:1186-97.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1186-1197
-
-
Mahadevan, D.1
Von Hoff, D.D.2
-
9
-
-
79955068416
-
Analysis of the human pancreatic stellate cell secreted proteome
-
Wehr AY, Furth EE, Sangar V, Blair IA, Yu KH. Analysis of the human pancreatic stellate cell secreted proteome. Pancreas 2011;40:557-66.
-
(2011)
Pancreas
, vol.40
, pp. 557-566
-
-
Wehr, A.Y.1
Furth, E.E.2
Sangar, V.3
Blair, I.A.4
Yu, K.H.5
-
10
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009;106:4254-9.
-
(2009)
Proc Natl Acad Sci U.S.A.
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
DuPree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
-
11
-
-
44749083057
-
Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan
-
Tammi RH, Kultti A, Kosma VM, Pirinen R, Auvinen P, Tammi MI. Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan. Semin Cancer Biol 2008; 18:288-95.
-
(2008)
Semin Cancer Biol
, vol.18
, pp. 288-295
-
-
Tammi, R.H.1
Kultti, A.2
Kosma, V.M.3
Pirinen, R.4
Auvinen, P.5
Tammi, M.I.6
-
12
-
-
67649842536
-
Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer
-
Ohlund D, Lundin C, Ardnor B, Oman M, Naredi P, Sund M. Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer. Br J Cancer 2009;101:91-7.
-
(2009)
Br J Cancer
, vol.101
, pp. 91-97
-
-
Ohlund, D.1
Lundin, C.2
Ardnor, B.3
Oman, M.4
Naredi, P.5
Sund, M.6
-
13
-
-
84875327763
-
Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop
-
Ohlund D, Franklin O, Lundberg E, Lundin C, Sund M. Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop. BMC Cancer 2013;13:154.
-
(2013)
BMC Cancer
, vol.13
, pp. 154
-
-
Ohlund, D.1
Franklin, O.2
Lundberg, E.3
Lundin, C.4
Sund, M.5
-
14
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, et al. Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 2008;14:5995-6004.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5995-6004
-
-
Bailey, J.M.1
Swanson, B.J.2
Hamada, T.3
Eggers, J.P.4
Singh, P.K.5
Caffery, T.6
-
15
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014;25:735-47.
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
-
16
-
-
43549107334
-
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
-
Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, et al. Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood 2008;111:3742-50.
-
(2008)
Blood
, vol.111
, pp. 3742-3750
-
-
Carter, B.Z.1
Mak, D.H.2
Schober, W.D.3
Dietrich, M.F.4
Pinilla, C.5
Vassilev, L.T.6
-
17
-
-
0035978511
-
Triptolide induced cytotoxic effects on human promyelocytic leukemia T cell lymphoma and human hepatocellular carcinoma cell lines
-
Chan EW, Cheng SC, Sin FW, Xie Y. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol Lett 2001;122:81-7.
-
(2001)
Toxicol Lett
, vol.122
, pp. 81-87
-
-
Chan, E.W.1
Cheng, S.C.2
Sin, F.W.3
Xie, Y.4
-
18
-
-
67549087949
-
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
-
Chen YW, Lin GJ, Chia WT, Lin CK, Chuang YP, Sytwu HK. Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol 2009;45:562-8.
-
(2009)
Oral Oncol
, vol.45
, pp. 562-568
-
-
Chen, Y.W.1
Lin, G.J.2
Chia, W.T.3
Lin, C.K.4
Chuang, Y.P.5
Sytwu, H.K.6
-
19
-
-
65249111669
-
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms
-
Dudeja V, Mujumdar N, Phillips P, Chugh R, Borja-Cacho D, Dawra RK, et al. Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology 2009;136: 1772-82.
-
(2009)
Gastroenterology
, vol.136
, pp. 1772-1782
-
-
Dudeja, V.1
Mujumdar, N.2
Phillips, P.3
Chugh, R.4
Borja-Cacho, D.5
Dawra, R.K.6
-
20
-
-
84875238979
-
Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity
-
Krosch TC, Sangwan V, Banerjee S, Mujumdar N, Dudeja V, Saluja AK, et al. Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity. Am J Surg 2013;205:387-96.
-
(2013)
Am J Surg
, vol.205
, pp. 387-396
-
-
Krosch, T.C.1
Sangwan, V.2
Banerjee, S.3
Mujumdar, N.4
Dudeja, V.5
Saluja, A.K.6
-
21
-
-
35148831187
-
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein
-
Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE, et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein. Cancer Res 2007;67:9407-16.
-
(2007)
Cancer Res
, vol.67
, pp. 9407-9416
-
-
Phillips, P.A.1
Dudeja, V.2
McCarroll, J.A.3
Borja-Cacho, D.4
Dawra, R.K.5
Grizzle, W.E.6
-
22
-
-
84888367596
-
Triptolide-induced cell death in pancreatic cancer is mediated by OGlcNAc modification of transcription factor Sp1
-
Banerjee S, Sangwan V, McGinn O, Chugh R, Dudeja V, Vickers SM, et al. Triptolide-induced cell death in pancreatic cancer is mediated by OGlcNAc modification of transcription factor Sp1. J Biol Chem 2013;288: 33927-38.
-
(2013)
J Biol Chem
, vol.288
, pp. 33927-33938
-
-
Banerjee, S.1
Sangwan, V.2
McGinn, O.3
Chugh, R.4
Dudeja, V.5
Vickers, S.M.6
-
23
-
-
84878221562
-
Minnelide reduces tumor burden in preclinical models of osteosarcoma
-
Banerjee S, Thayanithy V, Sangwan V, Mackenzie TN, Saluja AK, Subramanian S. Minnelide reduces tumor burden in preclinical models of osteosarcoma. Cancer Lett 2013;335:412-20.
-
(2013)
Cancer Lett
, vol.335
, pp. 412-420
-
-
Banerjee, S.1
Thayanithy, V.2
Sangwan, V.3
Mackenzie, T.N.4
Saluja, A.K.5
Subramanian, S.6
-
24
-
-
84867793735
-
A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer
-
Chugh R, Sangwan V, Patil SP, Dudeja V, Dawra RK, Banerjee S, et al. A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med 2012;4:156ra39.
-
(2012)
Sci Transl Med
, vol.4
, pp. 156-239
-
-
Chugh, R.1
Sangwan, V.2
Patil, S.P.3
Dudeja, V.4
Dawra, R.K.5
Banerjee, S.6
-
25
-
-
84904251521
-
Sorafenib and triptolide as combination therapy for hepatocellular carcinoma
-
Alsaied OA, Sangwan V, Banerjee S, Krosch TC, Chugh R, Saluja A, et al. Sorafenib and triptolide as combination therapy for hepatocellular carcinoma. Surgery 2014;156:270-9.
-
(2014)
Surgery
, vol.156
, pp. 270-279
-
-
Alsaied, O.A.1
Sangwan, V.2
Banerjee, S.3
Krosch, T.C.4
Chugh, R.5
Saluja, A.6
-
26
-
-
84899730785
-
CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide
-
Banerjee S, Nomura A, Sangwan V, Chugh R, Dudeja V, Vickers SM, et al. CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide. Clin Cancer Res 2014;20:2388-99.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2388-2399
-
-
Banerjee, S.1
Nomura, A.2
Sangwan, V.3
Chugh, R.4
Dudeja, V.5
Vickers, S.M.6
-
27
-
-
84885439105
-
Minnelide: A novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo
-
Rousalova I, Banerjee S, Sangwan V, Evenson K, McCauley JA, Kratzke R, et al. Minnelide: A novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo. PLoS ONE 2013;8:e77411.
-
(2013)
PLoS ONE
, vol.8
, pp. e77411
-
-
Rousalova, I.1
Banerjee, S.2
Sangwan, V.3
Evenson, K.4
McCauley, J.A.5
Kratzke, R.6
-
28
-
-
2442597186
-
Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation
-
Itano N, Sawai T, Atsumi F, Miyaishi O, Taniguchi S, Kannagi R, et al. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. J Biol Chem 2004;279:18679-87.
-
(2004)
J Biol Chem
, vol.279
, pp. 18679-18687
-
-
Itano, N.1
Sawai, T.2
Atsumi, F.3
Miyaishi, O.4
Taniguchi, S.5
Kannagi, R.6
-
29
-
-
84872849385
-
Isolation of normal and cancer-associated fibroblasts from fresh tissues by Fluorescence Activated Cell Sorting (FACS
-
Sharon Y, Alon L, Glanz S, Servais C, Erez N. Isolation of normal and cancer-associated fibroblasts from fresh tissues by Fluorescence Activated Cell Sorting (FACS). J Vis Exp 2013:e4425.
-
(2013)
J Vis Exp
, pp. e4425
-
-
Sharon, Y.1
Alon, L.2
Glanz, S.3
Servais, C.4
Erez, N.5
-
31
-
-
84876786403
-
A starring role for stellate cells in the pancreatic cancer microenvironment
-
Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 2013;144: 1210-9.
-
(2013)
Gastroenterology
, vol.144
, pp. 1210-1219
-
-
Apte, M.V.1
Wilson, J.S.2
Lugea, A.3
Pandol, S.J.4
-
32
-
-
84872611820
-
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
-
Provenzano PP, Hingorani SR. Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br J Cancer 2013;108:1-8.
-
(2013)
Br J Cancer
, vol.108
, pp. 1-8
-
-
Provenzano, P.P.1
Hingorani, S.R.2
-
33
-
-
84925445547
-
The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: A systematic review and critical appraisal
-
Bijlsma MF, Van Laarhoven HW. The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: A systematic review and critical appraisal. Cancer Metastasis Rev 2015; 34:97-114.
-
(2015)
Cancer Metastasis Rev
, vol.34
, pp. 97-114
-
-
Bijlsma, M.F.1
Van Laarhoven, H.W.2
-
34
-
-
84907485104
-
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
-
Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 2014;159:80-93.
-
(2014)
Cell
, vol.159
, pp. 80-93
-
-
Sherman, M.H.1
Yu, R.T.2
Engle, D.D.3
Ding, N.4
Atkins, A.R.5
Tiriac, H.6
-
35
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
-
36
-
-
84903388405
-
Hyaluronan: Biosynthesis and signaling
-
Vigetti D, Karousou E, Viola M, Deleonibus S, De Luca G, Passi A. Hyaluronan: Biosynthesis and signaling. Biochim Biophys Acta 2014; 1840:2452-9.
-
(2014)
Biochim Biophys Acta
, vol.1840
, pp. 2452-2459
-
-
Vigetti, D.1
Karousou, E.2
Viola, M.3
Deleonibus, S.4
De Luca, G.5
Passi, A.6
-
37
-
-
0022352427
-
Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface
-
Meizel S. Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anatomy 1985;174:285-302.
-
(1985)
Am J Anatomy
, vol.174
, pp. 285-302
-
-
Meizel, S.1
-
38
-
-
33645743816
-
Inhibitory effects of Triptolide on interferon-gammainduced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves' ophthalmopathy
-
Yan SX, Wang Y. Inhibitory effects of Triptolide on interferon-gammainduced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves' ophthalmopathy. Clin Experiment Ophthalmol 2006; 34:265-71.
-
(2006)
Clin Experiment Ophthalmol
, vol.34
, pp. 265-271
-
-
Yan, S.X.1
Wang, Y.2
-
39
-
-
80052999905
-
Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1
-
Jokela TA, Makkonen KM, Oikari S, Karna R, Koli E, Hart GW, et al. Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1. J Biol Chem 2011;286: 33632-40.
-
(2011)
J Biol Chem
, vol.286
, pp. 33632-33640
-
-
Jokela, T.A.1
Makkonen, K.M.2
Oikari, S.3
Karna, R.4
Koli, E.5
Hart, G.W.6
-
40
-
-
33745838565
-
Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene
-
Monslow J, Williams JD, Fraser DJ, Michael DR, Foka P, Kift-Morgan AP, et al. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. J Biol Chem 2006;281:18043-50.
-
(2006)
J Biol Chem
, vol.281
, pp. 18043-18050
-
-
Monslow, J.1
Williams, J.D.2
Fraser, D.J.3
Michael, D.R.4
Foka, P.5
Kift-Morgan, A.P.6
-
41
-
-
79957588142
-
The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell
-
Michael DR, Phillips AO, Krupa A, Martin J, Redman JE, Altaher A, et al. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. J Biol Chem 2011;286:19523-32.
-
(2011)
J Biol Chem
, vol.286
, pp. 19523-19532
-
-
Michael, D.R.1
Phillips, A.O.2
Krupa, A.3
Martin, J.4
Redman, J.E.5
Altaher, A.6
|