Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-κB signal pathway

International Journal of Oncology

Volumn 48, Issue 4, 2016, Pages 1391-1398

  Chen, Shaoqin ^a   Chen, Wei ^a   Zhang, Xiang ^a   Lin, Suyong ^a   Chen, Zhihua ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Akt; colorectal cancer; KiSS 1; matrix metalloprotease; metastasis; NF B; PI3K

Indexed keywords

GELATINASE B; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; KISS1 PROTEIN, HUMAN; KISSPEPTIN;

APOPTOSIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; EXPRESSION VECTOR; FLUORESCENCE ACTIVATED CELL SORTING; GENE; GENE FUNCTION; GENE OVEREXPRESSION; HCT116 CELL LINE; HUMAN; HUMAN CELL; KISS 1 GENE; METASTASIS POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STABLE TRANSFECTION; WESTERN BLOTTING; BIOSYNTHESIS; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HCT 116 CELL LINE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR INVASION;

APOPTOSIS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; KISSPEPTINS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84958953815     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3368     Document Type: Article

References (26)

1. Meijer G. GLOBOCAN. 1: Cancer incidence, and mortality worldwide. J Clin Pathol. 53: 164, 2000.
2. Wang H, Dwyer-Lindgren L, Lofgren KT, Rajaratnam JK, Marcus JR, Levin-Rector A, Levitz CE, Lopez AD, and Murray CJ. Age-specific, and sex-specific mortality in 187 countries, 1970-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380: 2071-2094, 2012.
3. Blanco-Calvo M, Concha Á, Figueroa A, Garrido F, and Valladares-Ayerbes M. Colorectal cancer classification, and cell heterogeneity: A systems oncology approach. Int J Mol Sci. 16: 13610-13632, 2015.
4. Langley RR, and Fidler IJ. The seed, and soil hypothesis revisited - The role of tumor-stroma interactions in metastasis to different organs. Int J Cancer. 128: 2527-2535, 2011.
5. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, and Bos JL. Genetic alterations during colorectal-Tumor development. N Engl J Med. 319: 525-532, 1988.
6. Zucker S, Lysik RM, Zarrabi MH, and Moll U. M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer, and breast cancer. Cancer Res. 53: 140-146, 1993.
7. Onisto M, Garbisa S, Caenazzo C, Freda MP, Di F, Nitti D, and Stetler-Stevenson WG. Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases, and inhibitors involved in tumor matrix invasion. Diagn Mol Pathol. 2: 74-80, 1993.
8. Tutton MG, George ML, Eccles SA, Burton S, Swift RI, and Abulafi AM. Use of plasma MMP-2, and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients. Int J Cancer. 107: 541-550, 2003.
9. Liabakk NB, Talbot I, Smith RA, Wilkinson K, and Balkwill F. Matrix metalloprotease 2 (MMP-2), and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res. 56: 190-196, 1996.
10. Cheng JC, Chou CH, Kuo ML, and Hsieh CY. Radiationenhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway. Oncogene. 25: 7009-7018, 2006.
11. Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, and Welch DR. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst. 88: 1731-1737, 1996.
12. Lee J-H, and Welch DR. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 57: 2384-2387, 1997.
13. Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan Y T, and Prabhu SD. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: Role of nuclear factorkappaB, and inflammatory activation. Circulation. 119: 1386-1397, 2009.
14. Fearon ER, and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 61: 759-767, 1990.
15. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, and Starling N. Colorectal cancer. Lancet. 375: 1030-1047, 2010.
16. Shinto E, Baker K, Tsuda H, Mochizuki H, Ueno H, Matsubara O, Foulkes WD, and Jass JR. Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer. Dis Colon Rectum. 49: 1193-1202, 2006.
17. Garc?a-Solano J, Conesa-Zamora P, Trujillo-Santos J, Torres-Moreno D, Mdkinen MJ, and P?rez-Guillermo M. Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5?2 chain and SMAD4 in colorectal serrated adenocarcinoma. Hum Pathol. 43: 1094-1102, 2012.
18. Matrisian LM. Metalloproteinases, and their inhibitors in matrix remodeling. Trends Genet. 6: 121-125, 1990.
19. Yan C, Wang H, and Boyd DD. KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha-induced block of p65/p50 nuclear translocation. J Biol Chem. 276: 1164-1172, 2001.
20. Criswell T, Leskov K, Miyamoto S, Luo G, and Boothman DA. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene. 22: 5813-5827, 2003.
21. Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S, and Schmidt-Ullrich R. Stress, and radiationinduced activation of multiple intracellular signaling pathways. Radiat Res. 159: 283-300, 2003.
22. Ruhul Amin AR, Senga T, Oo ML, Thant AA, and Hamaguchi M. Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, Akt, and Erk. Genes Cells. 8: 515-523, 2003.
23. Vivanco I, and Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2: 489-501, 2002.
24. Arlt A, and Schäfer H. NFkappaB-dependent chemoresistance in solid tumors. Int J Clin Pharmacol Ther. 40: 336-347, 2002.
25. Karin M, Cao Y, Greten FR, and Li ZW. NF-kappaB in cancer: From innocent bystander to major culprit. Nat Rev Cancer. 2: 301-310, 2002.
26. Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, and Sizemore N. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B, and beta-catenin. Oncogene. 24: 1021-1031, 2005.