Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation

Molecular and Cellular Biochemistry

Volumn 412, Issue 1-2, 2016, Pages 269-280

  Hanafi, Mervat Y ^a   Saleh, Moustafa M ^a   Saad, Mohamed I ^a,b   Abdelkhalek, Taha M ^a   Kamel, Maher A ^a  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Glucose sensing; Malnutrition; Obesity; Oxidative stress; Transgenerational inheritance

Indexed keywords

8 OXO DEOXY GUANINE; DNA; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DNA CONTENT; DOWN REGULATION; FEMALE; FETUS; FETUS DEVELOPMENT; FETUS LIVER; GENE DOSAGE; GENE EXPRESSION; GENE OVEREXPRESSION; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; INHERITANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MALNUTRITION; MATERNAL OBESITY; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PERINATAL PERIOD; PREGNANCY OUTCOME; PROGENY; PROTEIN EXPRESSION; RAT; RISK FACTOR; SEX DIFFERENCE; TISSUE LEVEL; UPREGULATION; WEIGHT GAIN; ANIMAL; BLOOD; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; OBESITY; PREGNANCY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; INSULIN; INSULIN RESISTANCE; MALNUTRITION; OBESITY; PREGNANCY; PREGNANCY OUTCOME; RATS;

EID: 84958944972     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2633-6     Document Type: Article

References (42)

1. Heard E, Martienssen RA (2014) Transgenerational epigenetic inheritance: myths and mechanisms. Cell 157:95–109
2. Hales CN, Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595–601
3. Hales CN, Barker DJ (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5–20
4. Plagemann A, Harder T, Rake A, Melchior K, Rohde W, Dorner G (2000) Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams. J Nutr 130:2582–2589
5. Godfrey KM (2002) The role of the placenta in fetal programming—a review. Placenta 23(Suppl A):S20–S27. doi:10.1053/plac.2002.0773
6. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135:1382–1386
7. Dabelea D, Crume T (2011) Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes 60:1849–1855
8. Rasmussen KM, Abrams B, Bodnar LM, Butte NF, Catalano PM, Siega-Riz AM (2010) Recommendations for weight gain during pregnancy in the context of the obesity epidemic. Obstet Gynecol 116:1191
9. Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, Dietz PM (2007) Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care 30:2070–2076. doi:10.2337/dc06-2559a
10. Veenendaal MV, Painter RC, Rooij S, Bossuyt PM, Post J, Gluckman PD, Hanson MA, Roseboom TJ (2013) Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine. BJOG 120:548–554
11. Lagisz M, Blair H, Kenyon P, Uller T, Raubenheimer D, Nakagawa S (2014) Transgenerational effects of caloric restriction on appetite: a meta-analysis. Obes Rev 15:294–309
12. Okitolonda W, Brichard S, Henquin J-C (1987) Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat. Diabetologia 30:946–951
13. Singla P, Bardoloi A, Parkash AA (2010) Metabolic effects of obesity: a review. World J Diabetes 1:76
14. Scholl TO, Sowers M, Chen X, Lenders C (2002) Maternal glucose concentration influences fetal growth, gestation, and pregnancy complications. Obstet Gynecol Surv 57:141–142
15. Kamel MA (2012) Prenatal effects of different intra-uterine milieus on fetal glucose sensing mechanisms during gestation in rats. J Diabetes Metab 3:181
16. Thorens B (2015) GLUT2, glucose sensing and glucose homeostasis. Diabetologia 58:221–232
17. MacDonald PE, Joseph JW, Rorsman P (2005) Glucose-sensing mechanisms in pancreatic β-cells. Philos Trans R Soc Lond B 360:2211–2225
18. Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195–1214
19. James AM, Collins Y, Logan A, Murphy MP (2012) Mitochondrial oxidative stress and the metabolic syndrome. Trends Endocrinol Metab 23:429–434
20. Choi YS, Kim S, Pak YK (2001) Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin Pract 54:S3–S9
21. Montier LLC, Deng JJ, Bai Y (2009) Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 36:125–131
22. Diano S, Horvath TL (2012) Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. Trends Mol Med 18:52–58
23. Krauss S, Zhang C-Y, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB (2003) Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J Clin Investig 112:1831
24. Kamel MA, Helmy MH, Hanafi MY, Mahmoud SA, Elfetooh HA, Badr MS (2014) Maternal obesity and malnutrition in rats differentially affect glucose sensing in the muscles and adipose tissues in the offspring. Int J Biochem Res Rev 4:440–469
25. Amoli MM, Moosavizadeh R, Larijani B (2005) Optimizing conditions for rat pancreatic islets isolation. Cytotechnology 48:75–78
26. Piantadosi CA, Suliman HB (2006) Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J Biol Chem 281:324–333
27. Parton LE, Diraison F, Neill SE, Ghosh SK, Rubino MA, Bisi JE, Briscoe CP, Rutter GA (2004) Impact of PPARγ overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays. Am J Physiol Endocrinol Metab 287:E390–E404
28. Berraondo B, Marti A, Duncan J, Trayhurn P, Martinez J (2000) Up-regulation of muscle UCP2 gene expression by a new beta3-adrenoceptor agonist, trecadrine, in obese (cafeteria) rodents, but down-regulation in lean animals. Int J Obes Relat Metab Disord 24:156–163
29. Ciapaite J, Bakker SJ, Van Eikenhorst G, Wagner MJ, Teerlink T, Schalkwijk CG, Fodor M, Ouwens DM, Diamant M, Heine RJ (2007) Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats. Biochimica et Biophysica Acta (BBA) 1772:307–316
30. Szuhai K, van den Ouweland JM, Dirks RW, Lemaître M, Truffert J-C, Janssen GM, Tanke HJ, Holme E, Maassen JA, Raap AK (2001) Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in myoclonus epilepsy and ragged-red fibers (MERRF) syndrome by a multiplex molecular beacon based real-time fluorescence PCR. Nucleic Acids Res 29:e13
31. Tal M, Liang Y, Najafi H, Lodish H, Matschinsky F (1992) Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J Biol Chem 267:17241–17247
32. Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM (1992) Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41:792–806
33. Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM (2002) Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition. Diabetes 51:2749–2756
34. Rencurel F, Waeber G, Antoine B, Rocchiccioli F, Maulard P, Girard J, Leturque A (1996) Requirement of glucose metabolism for regulation of glucose transporter type 2 (GLUT2) gene expression in liver. Biochem J 314:903–909
35. Camirand A, Vr Marie, Rr Rabelo, Silva JE (1998) Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle. Endocrinology 139:428–431
36. De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ (2007) Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J 21:1153–1163
37. Hajer GR, van Haeften TW, Visseren FL (2008) Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959–2971
38. Kaati G, Bygren LO, Edvinsson S (2002) Cardiovascular and diabetes mortality determined by nutrition during parents’ and grandparents’ slow growth period. Eur J Hum Genet 10:682–688
39. Pinheiro A, Salvucci I, Aguila M, Mandarim-de-Lacerda C (2008) Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of rats. Clin Sci 114:381–392
40. Graus-Nunes F, Frantz EDC, Lannes WR, da Silva Menezes MC, Mandarim-de-Lacerda CA, Souza-Mello V (2015) Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny. Nutrition 31:380–387
41. Winzell MS, Ahrén B (2004) The high-fat diet–fed mouse a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 53:S215–S219
42. Devedjian J-C, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F (2000) Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes. J Clin Investig 105:731