Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness with Aging in Primates

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 4, 2016, Pages 700-706

  Zhang, Jie ^a   Zhao, Xin ^a   Vatner, Dorothy E ^a   McNulty, Tara ^a   Bishop, Sanford ^a   Sun, Zhe ^b   Shen, You Tang ^a   Chen, Li ^a   Meininger, Gerald A ^b   Vatner, Stephen F ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

abdominal aorta; aging; collagen; elastin; hypertension; nonhuman primates

Indexed keywords

COLLAGEN; ELASTIN;

ABDOMINAL AORTA; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ANEURYSM; AORTA PRESSURE; ARTERIAL STIFFNESS; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HEART RATE; HYPERTENSION; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; THORACIC AORTA; VASCULAR SMOOTH MUSCLE CELL; AGE; ANIMAL; AORTA DISEASE; ARTERIAL PRESSURE; COMPARATIVE STUDY; MACACA FASCICULARIS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RHESUS MONKEY;

AGE FACTORS; AGING; ANIMALS; AORTA, ABDOMINAL; AORTA, THORACIC; AORTIC DISEASES; ARTERIAL PRESSURE; COLLAGEN; ELASTIN; EXTRACELLULAR MATRIX; HYPERTENSION; MACACA FASCICULARIS; MACACA MULATTA; MALE; VASCULAR STIFFNESS;

EID: 84958824544     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.306563     Document Type: Article

References (40)

1. Pfeffer MA, Pfeffer JM, Frohlich ED. Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res. 1976;38:423-429.
2. McNulty M, Mahmud A, Feely J. Advanced glycation end-products and arterial stiffness in hypertension. Am J Hypertens. 2007;20:242-247. doi: 10.1016/j.amjhyper.2006.08.009.
3. Williams IM, Hughes OD, Townsend E, Winter RK, Lewis MH. Prevalence of abdominal aortic aneurysm in a hypertensive population. Ann R Coll Surg Engl. 1996;78:501-504.
4. Isselbacher EM. Epidemiology of thoracic aortic aneurysms, aortic dissection, intramural hematoma, and penetrating atherosclerotic ulcers. Aortic dissection and related syndromes. Dev Cardiovasc Med 2007;260:3-15.
5. Lee HY, Oh BH. Aging and arterial stiffness. Circ J. 2010;74:2257-2262.
6. Rogers WJ, Hu YL, Coast D, Vido DA, Kramer CM, Pyeritz RE, Reichek N. Age-associated changes in regional aortic pulse wave velocity. J Am Coll Cardiol. 2001;38:1123-1129.
7. Taviani V, Hickson SS, Hardy CJ, McEniery CM, Patterson AJ, Gillard JH, Wilkinson IB, Graves MJ. Age-related changes of regional pulse wave velocity in the descending aorta using Fourier velocity encoded M-mode. Magn Reson Med. 2011;65:261-268. doi: 10.1002/mrm.22590.
8. Westenberg JJ, Scholte AJ, Vaskova Z, van der Geest RJ, Groenink M, Labadie G, van den Boogaard PJ, Radonic T, Hilhorst-Hofstee Y, Mulder BJ, Kroft LJ, Reiber JH, de Roos A. Age-related and regional changes of aortic stiffness in the Marfan syndrome: assessment with velocity-encoded MRI. J Magn Reson Imaging. 2011;34:526-531. doi: 10.1002/jmri.22646.
9. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43:1239-1245. doi: 10.1161/01.HYP.0000128420.01881.aa.
10. Erbel R, Eggebrecht H. Aortic dimensions and the risk of dissection. Heart. 2006;92:137-142. doi: 10.1136/hrt.2004.055111.
11. Wolinsky H, Glagov S. Comparison of abdominal and thoracic aortic medial structure in mammals. Deviation of man from the usual pattern. Circ Res. 1969;25:677-686.
12. Kau T, Sinzig M, Gasser J, Lesnik G, Rabitsch E, Celedin S, Eicher W, Illiasch H, Hausegger KA. Aortic development and anomalies. Semin Intervent Radiol. 2007;24:141-152. doi: 10.1055/s-2007-980040.
13. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, van der Kuip DA, Hofman A, Witteman JC. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke. 2001;32:454-460.
14. Wykretowicz A, Gerstenberger P, Guzik P, Milewska A, Krauze T, Adamska K, Rutkowska A, Wysocki H. Arterial stiffness in relation to subclinical atherosclerosis. Eur J Clin Invest. 2009;39:11-16. doi: 10.1111/j.1365-2362.2008.02057.x.
15. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Gansner M, Depre C, Resuello RR, Natividad FF, Hunter WC, Genin GM, Elson EL, Vatner DE, Meininger GA, Vatner SF. Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res. 2010;107:615-619. doi: 10.1161/CIRCRESAHA.110.221846.
16. Sehgel NL, Zhu Y, Sun Z, Trzeciakowski JP, Hong Z, Hunter WC, Vatner DE, Meininger GA, Vatner SF. Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension. Am J Physiol Heart Circ Physiol. 2013;305:H1281-H1287. doi: 10.1152/ajpheart.00232.2013.
17. Devos DG, Rietzschel E, Heyse C, Vandemaele P, Van Bortel L, Babin D, Segers P, Westenberg JM, Achten R. MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta. J Magn Reson Imaging. 2015;41:765-772. doi: 10.1002/jmri.24592.
18. Nelson AJ, Worthley SG, Cameron JD, Willoughby SR, Piantadosi C, Carbone A, Dundon BK, Leung MC, Hope SA, Meredith IT, Worthley MI. Cardiovascular magnetic resonance-derived aortic distensibility: validation and observed regional differences in the elderly. J Hypertens. 2009;27:535-542.
19. Hickson SS, Butlin M, Graves M, Taviani V, Avolio AP, McEniery CM, Wilkinson IB. The relationship of age with regional aortic stiffness and diameter. JACC Cardiovasc Imaging. 2010;3:1247-1255. doi: 10.1016/j. jcmg.2010.09.016.
20. Farrar DJ, Bond MG, Sawyer JK, Green HD. Pulse wave velocity and morphological changes associated with early atherosclerosis progression in the aortas of cynomolgus monkeys. Cardiovasc Res. 1984;18:107-118.
21. Multicentre Aneurysm Screening Study Group (mass): Cost effectiveness analysis of screening for abdominal aortic aneurysms based on four year results from randomised controlled trial. BMJ. 2002;325:1135.
22. Nosaka T, Tanaka H, Watanabe I, Sato M, Matsuda M. Influence of regular exercise on age-related changes in arterial elasticity: mechanistic insights from wall compositions in rat aorta. Can J Appl Physiol. 2003;28:204-212.
23. Qiu H, Depre C, Ghosh K, Resuello RG, Natividad FF, Rossi F, Peppas A, Shen YT, Vatner DE, Vatner SF. Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates. Circulation. 2007;116:669-676. doi: 10.1161/CIRCULATIONAHA.107.689208.
24. Avolio A, Jones D, Tafazzoli-Shadpour M. Quantification of alterations in structure and function of elastin in the arterial media. Hypertension. 1998;32:170-175.
25. Wheeler JB, Mukherjee R, Stroud RE, Jones JA, Ikonomidis JS. Relation of murine thoracic aortic structural and cellular changes with aging to passive and active mechanical properties. J Am Heart Assoc. 2015;4:e001744. doi: 10.1161/JAHA.114.001744.
26. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens. 2003;21:3-12. doi: 10.1097/01.hjh.0000042892.24999.92.
27. Chamiot-Clerc P, Renaud JF, Safar ME. Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats. Hypertension. 2001;37:313-321.
28. Faber M, M|oller-Hou G. The human aorta. V. Collagen and elastin in the normal and hypertensive aorta. Acta Pathol Microbiol Scand. 1952;31:377-382.
29. Hosoda Y, Kawano K, Yamasawa F, Ishii T, Shibata T, Inayama S. Agedependent changes of collagen and elastin content in human aorta and pulmonary artery. Angiology. 1984;35:615-621.
30. Atanasova M, Dimitrova A, Ruseva B, Stoyanova A, Georgieva M, Konova E. Quantification of elastin, collagen and advanced glycation end products as functions of age and hypertension. In: Nagata T, ed. Senescence. InTech. DOI: 10.5772/33268. http://www.intechopen.com/books/senescence/ quantification-of-elastin-collagen-and-advanced-glycation-endproducts- as-functions-of-age-and-hyper. February 29, 2012.
31. Sauvage M, Hinglais N, Mandet C, Badier C, Deslandes F, Michel JB, Jacob MP. Localization of elastin mRNA and TGF-beta1 in rat aorta and caudal artery as a function of age. Cell Tissue Res. 1998;291:305-314.
32. Haskett D, Johnson G, Zhou A, Utzinger U, Vande Geest J. Microstructural and biomechanical alterations of the human aorta as a function of age and location. Biomech Model Mechanobiol. 2010;9:725-736. doi: 10.1007/ s10237-010-0209-7.
33. Ameer OZ, Salman IM, Avolio AP, Phillips JK, Butlin M. Opposing changes in thoracic and abdominal aortic biomechanical properties in rodent models of vascular calcification and hypertension. Am J Physiol Heart Circ Physiol. 2014;307:H143-H151. doi: 10.1152/ajpheart.00139.2014.
34. Ng K, Butlin M, Avolio AP. Persistent effect of early, brief angiotensinconverting enzyme inhibition on segmental pressure dependency of aortic stiffness in spontaneously hypertensive rats. J Hypertens. 2012;30:1782-1790. doi: 10.1097/HJH.0b013e3283562e35.
35. Lee J, Shen M, Parajuli N, Oudit GY, McMurtry MS, Kassiri Z. Genderdependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm. J Mol Med (Berl). 2014;92:939-949. doi: 10.1007/s00109-014-1178-6.
36. Hofmann Bowman M, Wilk J, Heydemann A, Kim G, Rehman J, Lodato JA, Raman J, McNally EM. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circ Res. 2010;106:145-154. doi: 10.1161/ CIRCRESAHA.109.209486.
37. Pezzini A, Del Zotto E, Giossi A, Volonghi I, Costa P, Padovani A. Transforming growth factor β signaling perturbation in the Loeys-Dietz syndrome. Curr Med Chem. 2012;19:454-460.
38. Sans M, Moragas A. Mathematical morphologic analysis of the aortic medial structure. Biomechanical implications. Anal Quant Cytol Histol. 1993;15:93-100.
39. Fornieri C, Quaglino D Jr, Mori G. Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations. Arterioscler Thromb. 1992;12: 1008-1016.
40. Sehgel NL, Sun Z, Hong Z, Hunter WC, Hill MA, Vatner DE, Vatner SF, Meininger GA. Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging. Hypertension. 2015;65:370-377. doi: 10.1161/HYPERTENSIONAHA.114.04456.