Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm

Journal of Molecular Medicine

Volumn 92, Issue 9, 2014, Pages 939-949

  Lee, Jiwon ^a,b   Shen, Mengcheng ^a,b   Parajuli, Nirmal ^a,b   Oudit, Gavin Y ^a,b   McMurtry, Michael Sean ^a,b   Kassiri, Zamaneh ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MAZANKOWSKI ALBERTA HEART INSTITUTE   (Canada)

Author keywords

Collagen; Elastin; Extracellular matrix; MT1 MMP; Thoracic aneurysm

Indexed keywords

CASPASE 3; COLLAGEN TYPE 1; COLLAGENASE 3; ELASTASE; ELASTIN; GELATINASE A; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; NEUTROPHIL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; COLLAGEN; TIMP2 PROTEIN, HUMAN; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; AORTIC REMODELLING; ARTICLE; ASCENDING AORTA; BICUSPID AORTIC VALVE; BODY MASS; CELL DENSITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SEX DIFFERENCE; SMOOTH MUSCLE FIBER; THORACIC AORTA ANEURYSM; VASCULAR DISEASE; AORTA; AORTA VALVE; CONGENITAL MALFORMATION; EXTRACELLULAR MATRIX; METABOLISM; MIDDLE AGED; PATHOLOGY; VALVULAR HEART DISEASE;

AORTA; AORTIC ANEURYSM, THORACIC; AORTIC VALVE; CASPASE 3; COLLAGEN; ELASTIN; EXTRACELLULAR MATRIX; FEMALE; HEART VALVE DISEASES; HUMANS; MALE; MATRIX METALLOPROTEINASE 14; MIDDLE AGED; PROTEOLYSIS; SEX FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84906312933     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1178-6     Document Type: Article

References (35)

1. Control. NCfIPa (1999-2007) WISQARS leading causes of death reports. http://webappa.cdc.gov/sasweb/ncipc/leadcaus10.html
2. Ruddy JM, Jones JA, Ikonomidis JS (2013) Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin. Prog Cardiovasc Dis 56:68-73
3. Ruddy JM, Jones JA, Spinale FG, Ikonomidis JS (2008) Regional heterogeneity within the aorta: relevance to aneurysm disease. J Thorac Cardiovasc Surg 136:1123-1130
4. Michelena HI, Khanna AD, Mahoney D, Margaryan E, Topilsky Y, Suri RM, Eidem B, Edwards WD, Sundt TM 3rd, Enriquez-Sarano M (2011) Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 306:1104-1112
5. Hope MD, Hope TA, Crook SE, Ordovas KG, Urbania TH, Alley MT, Higgins CB (2011) 4D flow CMR in assessment of valve-related ascending aortic disease. J Am Coll Cardiol Img 4:781-787
6. Maleki S, Bjorck HM, Folkersen L, Nilsson R, Renner J, Caidahl K, Franco-Cereceda A, Lanne T, Eriksson P (2013) Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve. J Mol Med (Berl) 91:129-139
7. Loffredo CA (2000) Epidemiology of cardiovascular malformations: prevalence and risk factors. Am J Med Genet 97:319-325
8. Braverman AC, Guven H, Beardslee MA, Makan M, Kates AM, Moon MR (2005) The bicuspid aortic valve. Curr Probl Cardiol 30:470-522
9. Bonow RO, Carabello BA, Kanu C, De Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT et al (2006) ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 114:e84-e231 (Pubitemid 44268973)
10. Boyum J, Fellinger EK, Schmoker JD, Trombley L, McPartland K, Ittleman FP, Howard AB (2004) Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves. J Thorac Cardiovasc Surg 127:686-691 (Pubitemid 38316173)
11. Ikonomidis JS, Jones JA, Barbour JR, Stroud RE, Clark LL, Kaplan BS, Zeeshan A, Bavaria JE, Gorman JH 3rd, Spinale FG et al (2007) Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. J Thorac Cardiovasc Surg 133:1028-1036 (Pubitemid 46435954)
12. Ikonomidis JS, Ruddy JM, Benton SM Jr, Arroyo J, Brinsa TA, Stroud RE, Zeeshan A, Bavaria JE, Gorman JH 3rd, Gorman RC et al (2012) Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors. Ann Thorac Surg 93:457-463
13. LeMaire SA, Wang X, Wilks JA, Carter SA, Wen S, Won T, Leonardelli D, Anand G, Conklin LD, Wang XL et al (2005) Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. J Surg Res 123:40-48 (Pubitemid 40094643)
14. Basu R, Fan D, Kandalam V, Lee J, Das SK, Wang X, Baldwin TA, Oudit GY, Kassiri Z (2012) Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. J Biol Chem 287:44083-44096
15. Basu R, Lee J, Morton JS, Takawale A, Fan D, Kandalam V, Wang X, Davidge ST, Kassiri Z (2013) TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Cardiovasc Res 98:360-371
16. Kandalam V, Basu R, Moore L, Fan D, Wang X, Jaworski DM, Oudit GY, Kassiri Z (2011) Lack of tissue inhibitor of metalloproteinases 2 leads to exacerbated left ventricular dysfunction and adverse extracellular matrix remodeling in response to biomechanical stress. Circulation 124:2094-2105
17. Abdulkareem N, Soppa G, Jones S, Valencia O, Smelt J, Jahangiri M (2013) Dilatation of the remaining aorta after aortic valve or aortic root replacement in patients with bicuspid aortic valve: a 5-year follow-up. Ann Thorac Surg 96:43-49
18. Abaci O, Kocas C, Kilickesmez KO, Uner S, Kucukoglu S (2013) Matrix metalloproteinase-2 and -9 levels in patients with dilated ascending aorta and bicuspid aortic valve. Echocardiography 30:121-126
19. Tzemos N, Lyseggen E, Silversides C, Jamorski M, Tong JH, Harvey P, Floras J, Siu S (2010) Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta. J Am Coll Cardiol 55:660-668
20. Pisano C, Maresi E, Balistreri CR, Candore G, Merlo D, Fattouch K, Bianco G, Ruvolo G (2012) Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications. Interact Cardiovasc Thorac Surg 14:300-306
21. Bauer M, Pasic M, Meyer R, Goetze N, Bauer U, Siniawski H, Hetzer R (2002) Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve. Ann Thorac Surg 74:58-62 (Pubitemid 34734646)
22. Della Corte A, Quarto C, Bancone C, Castaldo C, Di Meglio F, Nurzynska D, De Santo LS, De Feo M, Scardone M, Montagnani S et al (2008) Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling. J Thorac Cardiovasc Surg 135:8-18, 18 e11-12
23. Ikonomidis JS, Ivey CR, Wheeler JB, Akerman AW, Rice A, Patel RK, Stroud RE, Shah AA, Hughes CG, Ferrari G et al (2013) Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease. J Thorac Cardiovasc Surg 145:1326-1333
24. Mohamed SA, Noack F, Schoellermann K, Karluss A, Radtke A, Schult-Badusche D, Radke PW, Wenzel BE, Sievers HH (2012) Elevation ofmatrixmetalloproteinases in different areas of ascending aortic aneurysms in patients with bicuspid and tricuspid aortic valves. Sci World J 2012:806261
25. Holmes KW, Maslen CL, Kindem M, Kroner BL, Song HK, Ravekes W, Dietz HC, Weinsaft JW, Roman MJ, Devereux RB et al (2013) GenTAC registry report: gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection. Am J Med Genet A 161A:779-786
26. Lepidi S, Kenagy RD, Raines EW, Chiu ES, Chait A, Ross R, Clowes AW (2001) MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen. J Vasc Surg 34:1111-1118 (Pubitemid 33660675)
27. Kandalam V, Basu R, Abraham T, Wang X, Soloway PD, Jaworski DM, Oudit GY, Kassiri Z (2010) TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation. Circ Res 106:796-808
28. Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z (2014) Myocardial recovery from ischemia- reperfusion is compromised in the absence of tissue inhibitor of met a l loproteinase 4. Circ Heart Fail. doi:10.1161/CIRCHEARTFAILURE.114.001113
29. Wagsater D, Paloschi V, Hanemaaijer R, Hultenby K, Bank RA, Franco-Cereceda A, Lindeman JH, Eriksson P (2013) Impaired collagen biosynthesis and cross-linking in aorta of patients with bicuspid aortic valve. J Am Heart Assoc 2:e000034
30. Zhang X, Thatcher S, Wu C, Daugherty A, Cassis LA (2014) Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms. J Vasc Surg
31. Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA (2012) Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110:e73-e85
32. Bloomer LD, Bown MJ, Tomaszewski M(2012) Sexual dimorphism of abdominal aortic aneurysms: a striking example of "male disadvantage" in cardiovascular disease. Atherosclerosis 225:22-28
33. Wu XF, Zhang J, Paskauskas S, Xin SJ, Duan ZQ (2009) The role of estrogen in the formation of experimental abdominal aortic aneurysm. Am J Surg 197:49-54
34. Laser A, Ghosh A, Roelofs K, Sadiq O, McEvoy B, DiMusto P, Eliason J, Upchurch GR Jr (2014) Increased estrogen receptor alpha in experimental aortic aneurysms in females compared with males. J Surg Res 186:467-474
35. Yeap BB, Hyde Z, Norman PE, Chubb SA, Golledge J (2010) Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men. J Clin Endocrinol Metab 95:1123-1130