Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing

Oncotarget

Volumn 7, Issue 7, 2016, Pages 8067-8077

  Van de Glind, Gerline ^a   Rebel, Heggert ^a   Van Kempen, Marika ^a   Tensen, Kees ^a   De Gruijl, Frank ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CPD retaining basal cells; Dose fractionation; Hyperkeratotic tumors; UV carcinogenesis

Indexed keywords

NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; CARCINOGEN; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CELL DIVISION; CONTROLLED STUDY; DNA DAMAGE; EPIDERMIS HYPERPLASIA; FEMALE; GENE MUTATION; H RAS GENE; HAIRLESS MOUSE; LIFESPAN; MALE; MOUSE; MUTAGENESIS; N RAS GENE; NONHUMAN; NOTCH 1 GENE; NOTCH 2GENE; ONCOGENE; ONCOGENE K RAS; QUIESCENT STEM CELL; RADIATION DOSE FRACTIONATION; SKIN CARCINOGENESIS; SKIN CARCINOMA; STEM CELL; SUNBURN; TUMOR GROWTH; TUMOR REGRESSION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; ADVERSE EFFECTS; ANIMAL; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION; DRUG EFFECTS; ENZYME IMMUNOASSAY; EPIDERMIS; GENETICS; HYPERPLASIA; METABOLISM; MUTATION; PATHOLOGY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; SKIN NEOPLASMS;

ANIMALS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; EPIDERMIS; FEMALE; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; MALE; MICE; MICE, HAIRLESS; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 84958817570     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6932     Document Type: Article

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