Identification of a non-dividing subpopulation of mouse and human epidermal cells exhibiting high levels of persistent ultraviolet photodamage

Journal of Investigative Dermatology

Volumn 117, Issue 3, 2001, Pages 590-595

  Mitchell, David L ^a   Volkmer, Beate ^a,b   Breitbart, Eckhard W ^a,b   Byrom, Michelle ^a   Lowery, Megan G ^a   Greinert, Rüdiger ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b Department of Dermatology   (Germany)

Author keywords

Carcinogen retaining cell; Chronic UV exposure; Cyclobutane dimer; Hairless mouse; Photocarcinogenesis; Promotion; Stem cell

Indexed keywords

CYCLOBUTANE; MUTANT PROTEIN; PROTEIN P53; PYRIMIDINE DIMER; TUMOR PROMOTER;

ACTINIC KERATOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL CELL; BASEMENT MEMBRANE; CARCINOGENESIS; CELL DAMAGE; CELL DIVISION; CELL LOSS; CELL SUBPOPULATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; EPIDERMIS CELL; EPIDERMIS HYPERPLASIA; FEMALE; IRRADIATION; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; REDUCTION; SQUAMOUS CELL CARCINOMA; STEM CELL; SUN EXPOSURE; ULTRAVIOLET B RADIATION;

EID: 0034787020     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2001.01442.x     Document Type: Article

References (25)

1. Molecular mechanisms of ultraviolet radiation carcinogenesis
2. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells
3. Excision of pyrimidine dimers from epidermal DNA and nonsemiconservative epidermal DNA synthesis following ultraviolet irradiation of mouse skin
4. A role for sunlight in skin cancer: UV-induced p 53 mutations in squamous cell carcinoma
5. Ultraviolet radiation carcinogenesis
6. Dose response, wavelength dependence and rate of excision of ultraviolet radiation-induced pyrimidine dimers in mouse skin DNA
7. In situ molecular dosimetry ad tumor risk: UV-iduced DA damage and tumor latency time
8. Influence of ozone depletion on the incidence of skin cancer: Quantitative prediction
9. Formation of thymine containing dimers in skin exposed to ultraviolet radiation
10. Frequent clones of p53-mutated keratinocytes in normal human skin
11. Induction and persistence of pyrimidine dimers in the epidermal DNA of two strains of hairless mice
12. Nonmelanoma skin cancer in the United States: Incidence
13. Effects of chronic low dose ultraviolet-B radiation on DNA damage and repair in mouse skin
14. Attenuation of DNA damage in the dermis and epidermis of the albino hairless mouse by chronic exposure to ultraviolet-A and -B radiation
15. Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen
16. Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling
17. Quantitative detection of ultraviolet-induced photoproducts in mouse skin by immunohistochemistry
18. Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse
19. Incidence of nonmelanoma skin cancer in the United States
20. Genetic predisposition to melanoma
21. Involvement of follicular stem cells in forming not only the follicle but also the epidermis
22. Ultraviolet radiation and skin cancer of humans
23. Induction, repair, and accumulation of thymine dimers in the skin of UVB-irradiated hairless mice
24. Detection of thymine dimers in suprabasal and basal cells of chronically UV-B exposed hairless mice
25. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers