Gabapentin: Abuse, Dependence, and Withdrawal

Annals of Pharmacotherapy

Volumn 50, Issue 3, 2016, Pages 229-233

  Mersfelder, Tracey L ^a   Nichols, William H ^b  

^a FERRIS STATE UNIVERSITY   (United States)

^b BRONSON METHODIST HOSPITAL   (United States)

Author keywords

clinical pharmacy; drug abuse; pain management; psychiatry; substance abuse; withdrawal

Indexed keywords

GABAPENTIN; 4 AMINOBUTYRIC ACID; AMINE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ANALGESIA; DRUG ABUSE; DRUG DEPENDENCE; DRUG DEPENDENCE TREATMENT; DRUG MISUSE; HUMAN; PRIORITY JOURNAL; REVIEW; SUBSTANCE ABUSE; WITHDRAWAL SYNDROME; PSYCHOLOGY; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

AMINES; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HUMANS; SUBSTANCE ABUSE TREATMENT CENTERS; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 84958775177     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028015620800     Document Type: Review

References (27)

1. G.J.Sills. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 2006;6:108-113. doi:10.1016/j.coph.2005.11.003.
2. H.N.BockbraderD.WescheR.MillerS.ChapelN.JaniczekP.Burger. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010;49:661-669.
3. J.G.LeungD.Hall-FlavinS.NelsonK.A.SchmidtK.M.Schak. The role of gabapentin in the management of alcohol withdrawal and dependence. Ann Pharmacother. 2015;49:897-906. doi:10.1177/10600280115585849.
4. S.P.KruszewskiR.P.Paczynski. Gabapentin-induced delirium and dependence. J Psychiatr Pract. 2009;15:314-319.
5. V.KapilJ.L.GreenM.C.Le LaitD.M.WoodP.I.Dargan. Misuse of the γ-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK. Br J Clin Pharmacol. 2013;78:190-191. doi:10.1111/bcp.12277.
6. C.Victorri-VigneauM.GuerlaisP.Jolliet. Abuse, dependence, and withdrawal with gabapentin: a first case report. Pharmacopsychiatry. 2007;40:43-44. doi:10.1055/s-2006-958522.
7. C.PittengerP.H.Desan. Gabapentin abuse, and delirium tremens upon gabapentin withdrawal. J Clin Psychiatry. 2007;68:483.
8. J.S.MarkowitzR.FinkenbineH.MyrickL.KingW.H.Carson. Gabapentin abuse in a cocaine user: implications for treatment?J Clin Psychopharmacol. 1997;17:423-424.
9. R.R.ReevesR.S.Burke. Abuse of combinations of gabapentin and quetiapine. Prim Care Companion CNS Disord. 2014;16:10. doi:10.4088/PCC.14i01660.
10. L.ReccoppaR.MalcolmM.Ware. Gabapentin abuse in inmates with prior history of cocaine dependence. Am J Addict. 2004;13:321-323. doi:10.1080/10550490460300.
11. R.R.ReevesM.E.Lander. Potentiation of the effect of buprenorphine/naloxone with gabapentin or quetiapine. Am J Psychiatry. 2014;171:6. doi:10.1176/appi.ajp.2014.13111526.
12. C.R.W.BairdP.FoxL.A.Colvin. Gabapentinoid abuse in order to potentiate the effect of methadone: a survey among substance misusers. Eur Addict Res. 2014;20:115-118. doi:10.1159/000355268.
13. T.WilensC.ZulaufD.RylandN.CarrellasI.Catalina-Wellington. Prescription medication misuse among opioid dependent patients seeking inpatient detoxification. Am J Addict. 2015;24:173-177. doi:10.1111/ajad.12159.
14. T.R.HellwigR.HammerquistJ.Termaat. Withdrawal symptoms after gabapentin discontinuation. Am J Health Syst Pharm. 2010;67:910-912. doi:10.2146/ajhp090313.
15. C.K.FinchJ.EasonJ.B.Usery. Gabapentin withdrawal syndrome in a post-liver transplant patient. J Pain Palliat Care Pharmacother. 2010;24:236-238. doi:10.3109/15360288.2010.493927.
16. J.W.Norton. Gabapentin withdrawal syndrome. Clin Neuropharmacol. 2001;24:245-246.
17. R.Di FabioC.D’AgostinoF.Pierelli. Delirium after gabapentin withdrawal: case report. Can J Neurol Sci. 2013;40:126-127.
18. R.DrabkinL.Calhoun. Anorgasmia and withdrawal syndrome in a woman taking gabapentin. Can J Psychiatry. 2003;48:125-126.
19. K.T.TranD.HranickyT.LarkN.J.Jacob. Gabapentin withdrawal syndrome in the presence of a taper. Bipolar Disord. 2005;7:302-304.
20. L.MahM.Hart. Gabapentin withdrawal: case report in an older adult and review of the literature. J Am Geriatr Soc. 2013;61:1635-1637. doi:10.111/jgs.12427.
21. G.Cora-LocatelliB.D.GreenbergJ.D.MartinD.L.Murphy. Rebound psychiatric and physical symptoms after gabapentin discontinuation. J Clin Psychiatry. 1998;59;131.
22. S.SeeE.HendriksL.Hsiung. Akathisia induced by gabapentin withdrawal. Ann Pharmacother. 2011;45:e31. doi:10.1345/aph.1Q057.
23. P.I.RosebushG.M.MacQueenM.F.Mazurek. Catatonia following gabapentin withdrawal. J Clin Psychopharmacol. 1999;19:188-189.
24. F.BarruetoJ.GreenM.A.HowlandR.S.HoffmanL.S.Nelson. Gabapentin withdrawal presenting as status epilepticus. J Toxicol Clin Toxicol. 2002;40:925-928. doi:10.1081/CLT-120016965.
25. M.CarrascoS.C.RaiC.F.BearerS.Sundararajan. Neonatal gabapentin withdrawal syndrome. Pediatr Neurol. 2015;53:445-447. doi:10.1016/j.pediatrneurol.2015.06.023.
26. B.H.SmithC.HigginsA.BaldacchinoB.KiddJ.Bannister. Substance misuse of gabapentin. Br J Gen Pract. 2012;62:406-407. doi:10.3399/bjgp12X653516.
27. R.V.SmithM.R.LofwallJ.R.Havens. Abuse and diversion of gabapentin among nonmedical prescription opioid users in Appalachian Kentucky. Am J Psychiatry. 2015;172:487-488. doi:10.1176/appi.ajp.2014.14101272.