Withdrawal symptoms after gabapentin discontinuation

American Journal of Health-System Pharmacy

Volumn 67, Issue 11, 2010, Pages 910-912

  Hellwig, Thaddaus R ^a,b   Hammerquist, Rhonda ^c   Termaat, Jill ^d  

^a SOUTH DAKOTA STATE UNIVERSITY   (United States)

^b Sanford Medical Center   (United States)

^c SMC   (United States)

^d Center for Family Medicine   (United States)

Author keywords

Alcohols, ethyl; Anticonvulsants; Blood levels; Citalopram; Drug withdrawal; Ferrous sulfate; Gabapentin; Lactulose; Nadolol; Omeprazole; Spironolactone; Toxicity; Trazodone; Ursodiol

Indexed keywords

ALCOHOL; AMMONIA; BENZODIAZEPINE; GABAPENTIN; LACTULOSE; LORAZEPAM; RIFAXIMIN; TRAZODONE; 4 AMINOBUTYRIC ACID; AMINE; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ABDOMINAL PAIN; ADULT; AGITATION; ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL WITHDRAWAL; AMMONIA BLOOD LEVEL; ANXIETY; ARTICLE; CASE REPORT; CONFUSION; DISORIENTATION; DRUG DOSE INCREASE; EVENING DOSAGE; FEMALE; GASTROINTESTINAL ENDOSCOPY; HEADACHE; HEMATOCHEZIA; HEPATIC ENCEPHALOPATHY; HUMAN; INTENSIVE CARE UNIT; NARROW BAND IMAGING; NERVOUSNESS; PRIORITY JOURNAL; RESTLESSNESS; TREATMENT OUTCOME; VOMITING; BLOOD; MIDDLE AGED; WITHDRAWAL SYNDROME;

AMINES; ANTICONVULSANTS; BENZODIAZEPINES; CYCLOHEXANECARBOXYLIC ACIDS; ETHANOL; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MIDDLE AGED; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 77955895774     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp090313     Document Type: Article

References (23)

1. Goa KL, Sorkin EM. Gabapentin: a review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993; 43:409-27. (Pubitemid 23292119)
2. 2+ channel α2-δ ligand far beyond epilepsy therapy. Drugs Today. 2008; 44:353-68.
3. Maneuf YP, Luo ZD, Lee K. Alpha2delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol. 2006; 17:565-70. (Pubitemid 46107333)
4. Hendrich J, Van Minh AT, Heblich F et al. Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin. Proc Natl Acad Sci. 2008; 105:3628-33. (Pubitemid 351723603)
5. Taylor CP, Gee NS, Su TZ et al. A summary of mechanistic hypothesis of gabapentin pharmacology. Epilepsy Res. 1998; 29:233-49. (Pubitemid 28137601)
6. Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther. 2003; 25:81-104. (Pubitemid 36206739)
7. Vieta E, Goikolea MJ, Martinex-Aran A et al. A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder. J Clin Psychiatry. 2006; 67:434-7.
8. Mathew NT, Rapoport A, Saper J et al. Efficacy of gabapentin in migraine prophylaxis. Headache. 2001; 41:119-28. (Pubitemid 32209899)
9. Leandri M, Luzzani M, Cruccu G et al. Drug-resistant cluster headache responding to gabapentin: a pilot study. Cephalalgia. 2001; 21:744-6. (Pubitemid 34621541)
10. Brower KJ, Myra Kim H, Strobbe S et al. A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008; 32:1429-38.
11. Furieri FA, Nakamura-Palacios EM. Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2007; 68:1691-700. (Pubitemid 350247498)
12. Bonnet U, Banger M, Leweke M et al. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry. 1999; 32:107-9. (Pubitemid 29364444)
13. Voris J, Smith NL, Rao SM et al. Gabapentin for the treatment of ethanol withdrawal. Subst Abuse. 2003; 24:129-32. (Pubitemid 37087322)
14. Mariani JJ, Rosenthal RN, Tross S. A randomized, open-label controlled trial comparing gabapentin to phenobarbital in the treatment of alcohol withdrawal. Am J Addict. 2006; 15:76-84. (Pubitemid 43207192)
15. Bonnet U, Banger M, Leweke FM et al. Treatment of acute alcohol withdrawal with gabapentin; results from a controlled two-center trial. J Clin Psychopharmacol. 2003; 23:514-9. (Pubitemid 37128681)
16. Norton JW. Gabapentin withdrawal syndrome. Clin Neuropharmacol. 2001; 24:245-6.
17. Pittenger C, Desan PH. Gabapentin abuse, and delirium tremens upon gabapentin withdrawal. J Clin Psychiatry. 2007; 68:483-4. (Pubitemid 46506816)
18. Cora-Locatelli G, Greenberg BD, Martin JD et al. Rebound psychiatric and physical symptoms after gabapentin discontinuation. J Clin Psychiatry. 1998; 59:131. Letter.
19. Tran KT, Hranicky D, Lark T et al. Gabapentin withdrawal syndrome in the presence of a taper. Bipolar Disord. 2005; 7:302-4. (Pubitemid 40778895)
20. Barrueto F, Green J, Howland MA et al. Gabapentin withdrawal presenting as status epilepticus. J Toxicol Clin Toxicol. 2002; 40:925-8. (Pubitemid 36076747)
21. Victorri-Vigneau C, Guerlais M, Jolliet P. Abuse, dependency and withdrawal with gabapentin: a first case report. Pharmacopsychiatry. 2007; 40:37-45.
22. Drabkin R, Calhoun L. Anorgasmia and withdrawal syndrome in a woman taking gabapentin. Can J Psychiatry. 2003; 48:125-6. (Pubitemid 36402215)
23. Sullivan JT, Sykora K, Schneiderman J et al. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict. 1989; 84:1353-7. (Pubitemid 19281139)