Theory of Mind and Executive Control Deficits in Typically Developing Adults and Adolescents with High Levels of Autism Traits

Journal of Autism and Developmental Disorders

Volumn 46, Issue 6, 2016, Pages 2072-2087

  Gökçen, Elif ^a   Frederickson, Norah ^a   Petrides, K V ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alexithymia; Autism spectrum disorder; Executive control; Subclinical autism traits; Theory of mind

Indexed keywords

ADOLESCENCE; ADOLESCENT; ADULT; ADULTHOOD; AGE DISTRIBUTION; ALEXITHYMIA; ARTICLE; ASPERGER SYNDROME; AUTISM; COGNITIVE DEFECT; COMORBIDITY; COMPULSION; EMPATHY; EXECUTIVE FUNCTION; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN RELATION; INTELLIGENCE QUOTIENT; MALE; MENTAL HEALTH; NORMAL HUMAN; PRIORITY JOURNAL; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL DISABILITY; SOCIAL INTERACTION; THEORY OF MIND; TORONTO ALEXITHYMIA SCALE; AFFECTIVE SYMPTOMS; AUTISM SPECTRUM DISORDER; AWARENESS; PSYCHOLOGY; QUESTIONNAIRE; REFERENCE VALUE; YOUNG ADULT;

ADOLESCENT; ADULT; AFFECTIVE SYMPTOMS; AUTISM SPECTRUM DISORDER; AWARENESS; COMORBIDITY; EMPATHY; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; REFERENCE VALUES; SURVEYS AND QUESTIONNAIRES; THEORY OF MIND; YOUNG ADULT;

EID: 84958749503     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-016-2735-3     Document Type: Article

References (98)

1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
2. Apperly, I. A., Carroll, D. J., Samson, D., Qureshi, A., Humphreys, G. W., & Moffatt, G. (2010). Why are there limits on theory of mind use? Evidence from adults’ ability to follow instructions from an ignorant speaker. Quarterly Journal of Experimental Psychology,63, 1201–1217.
3. Austin, G., Groppe, K., & Elsner, B. (2014). The reciprocal relationship between executive function and theory of mind in middle childhood: a 1-year longitudinal perspective. Frontiers in Psychology,5, 655.
4. Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (1994). The twenty-item Toronto Alexithymia Scale-I. Item selection and cross-validation of the factor structure. Journal of Psychosomatic Research,38, 23–32.
5. Bagby, R. M., Taylor, G. J., Quilty, L. C., & Parker, J. D. (2007). Reexamining the factor structure of the 20-item Toronto alexithymia scale: commentary on Gignac, Palmer, and Stough. Journal of Personality Assessment,89, 258–264.
6. Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: Evidence from very high-functioning adults with autism or Asperger Syndrome. Journal of Child Psychology and Psychiatry,38, 813–822.
7. Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient (EQ). An investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders,34, 163–175.
8. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001a). The ‘Reading the Mind in the Eyes’ test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry,42, 241–251.
9. Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001b). The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders,31, 5–17.
10. Baron-Cohen, S., Wheelwright, S., Spong, A., Scahill, V., & Lawson, J. (2001c). Are intuitive physics and intuitive psychology independent? A test with children with Asperger syndrome. Journal of Developmental and Learning Disorders,5, 47–78.
11. Bauminger, N., & Kasari, C. (2000). Loneliness and friendship in high-functioning children with autism. Child Development,71, 447–456.
12. Bird, G., & Cook, R. (2013). Mixed emotions: The contribution of alexithymia to the emotional symptoms of autism. Translational Psychiatry,3, e285.
13. Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain,133, 1515–1525.
14. Blair, R. J. R. (1999). Psychophysiological responsiveness to the distress of others in children with autism. Personality and Individual Differences,26, 477–485.
15. Bölte, S., Duketis, E., Poustka, F., & Holtmann, M. (2011). Sex differences in cognitive domains and their clinical correlates in higher-functioning autism spectrum disorders. The International Journal of Research and Practice,15, 497–511.
16. Brainard, D. H. (1997). The psychophysics toolbox. Spatial Vision,10, 433–436.
17. Bull, R., Phillips, L. H., & Conway, C. (2008). The role of control functions in mentalizing: Dual task studies of theory of mind and executive functioning. Cognition,107, 663–672.
18. Capps, L., Kasari, C., Yirmiya, N., & Sigman, M. (1993). Parental perception of emotional expressiveness in children with autism. Journal of Consulting Clinical Psychology,61, 475–484.
19. Carlson, S. M., Claxton, L. J., & Moses, L. J. (2013). The relation between executive function and theory of mind is more than skin deep. Journal of Cognition and Development,16, 186–197.
20. Carlson, S. M., & Moses, L. J. (2001). Individual differences in inhibitory control and children’s theory of mind. Child Development,72, 1032–1053.
21. Carlson, S. M., Moses, L. J., & Breton, C. (2002). How specific is the relation between executive function and theory of mind? Contributions of inhibitory control and working memory. Infant and Child Development,11, 73–92.
22. Chamberlain, B., Kasari, C., & Rotheram-Fuller, E. (2007). Involvement or isolation? The social networks of children with autism in regular classrooms. Journal of Autism and Developmental Disorders,37, 230–242.
23. Christ, S. E., Kanne, S. M., & Reiersen, A. M. (2010). Executive function in individuals with subthreshold autism traits. Neuropsychology,24, 590–598.
24. Cianchetti, C., Corona, S., Foscoliano, M., Scalas, F., & Sannio-Fancello, G. (2005). Modified Wisconsin Card Sorting Test: Proposal of a supplementary sorting method. Archives of Clinical Neuropsychology,20, 555–558.
25. Cook, R., Brewer, R., Shah, P., & Bird, G. (2013). Alexithymia, not autism, predicts poor recognition of emotional facial expressions. Psychological Science,24, 723–732.
26. Corbett, B. A., Constantine, L. J., Hendren, R., Rocke, D., & Ozonoff, S. (2009). Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Research,166, 210–222.
27. Davis, M. H. (1980). A multidimensional approach to individual differences in empathy. JSAS Catalog of Selected Documents in Psychology,10, 85.
28. Dawson, G., Meltzoff, A., Osterling, J., & Rinaldi, J. (1998). Neuropsychological correlates of early autistic symptoms. Child Development,69, 1247–1482.
29. Decety, J. (2010). The neurodevelopment of empathy in humans. Developmental Neuroscience,32, 257–267.
30. Decety, J., & Jackson, P. L. (2006). A social-neuroscience perspective on empathy. Current Directions in Psychological Science,15, 54–58.
31. Decety, J., & Lamm, C. (2006). Human empathy through the lens of social neuroscience. Scientific World Journal,6, 1146–1163.
32. Dumontheil, I., Apperly, I. A., & Blakemore, S. J. (2010). Online usage of theory of mind continues to develop in late adolescence. Developmental Science,13, 331–338.
33. Dziobek, I., Fleck, S., Kalbe, E., Rogers, K., Hassenstab, J., Brand, M., et al. (2006). Introducing MASC: A movie for the assessment of social cognition. Journal of Autism and Developmental Disorders,36, 623–636.
34. Dziobek, I., Rogers, K., Fleck, S., Bahnemann, M., Heekeren, H. R., Wolf, O. T., & Convit, A. (2008). Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). Journal of Autism and Developmental Disorders,38, 464–473.
35. Eslinger, P. J., Moore, P., Anderson, C., & Grossman, M. (2011). Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. Journal of Neuropsychiatry and Clinical Neurosciences,23, 74–82.
36. Fan, Y. T., Chen, C., Chen, S. C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: evidence from fMRI and ERP measurements. Social Cognitive Affective Neuroscience,9, 1203–1213.
37. Frith, U., & Frith, C. D. (2003). Development and neurophysiology of mentalizing. Philosophical Transactions of the Royal Society of London Series B—Biological Sciences,358, 459–473.
38. Gökçen, E., Petrides, K. V., Hudry, K., Frederickson, N., & Smillie, L. D. (2014). Sub-threshold autism traits: The role of trait emotional intelligence and cognitive flexibility. British Journal of Psychology,105, 187–199.
39. Grant, A., & Berg, E. A. (1948). Behavioural analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. Journal of Experimental Psychology,38, 404–411.
40. Hadjikhani, N., Zurcher, N. R., Rogier, O., Hippolyte, L., Lemonnier, E., et al. (2014). Emotional contagion for pain is intact in autism spectrum disorders. Translational Psychiatry,4, e343.
41. Heavey, L., Phillips, W., Baron-Cohen, S., & Rutter, M. (2000). The Awkward Moments Test: A naturalistic measure of social understanding in autism. Journal of Autism and Developmental Disorders,30, 225–236.
42. Hill, E. L. (2004a). Evaluating the theory of executive dysfunction in autism. Developmental Review,24, 189–233.
43. Hill, E. L. (2004b). Executive dysfunction in autism. Trends in Cognitive Sciences,8, 26–32.
44. Horn, W. (1962). Leistungsprufsystem: LPS. Göttingen: Hogrefe.
45. Hughes, C. (1998a). Executive function in preschoolers: Links with theory of mind and verbal ability. British Journal of Developmental Psychology,16, 233–253.
46. Hughes, C. (1998b). Finding your marbles: Does preschoolers’ strategic behavior predict later understanding of mind? Developmental Psychology,34, 1326–1339.
47. Hughes, C., & Ensor, R. (2007). Executive function and theory of mind: Predictive relations from ages 2 to 4. Developmental Psychology,43, 1447–1459.
48. Jones, A. P., Happé, F. G., Gilbert, F., Burnett, S., & Viding, E. (2010). Feeling, caring, knowing: different types of empathy deficit in boys with psychopathic tendencies and autism spectrum disorder. Journal of Child Psychology and Psychiatry,51, 1188–1197.
49. Joseph, R. M., & Tager-Flusberg, H. (2004). The relationship of theory of mind and executive functions to symptom type and severity in children with autism. Development and Psychopathology,16, 137–155.
50. Jurado, M. B., & Rosselli, M. (2007). The elusive nature of executive functions: A review of our current understanding. Neuropsychological Review,17, 213–233.
51. Kaiser, S., Aschenbrenner, S., Pfüller, U., Roesch-Ely, D., & Weisbrod, M. (2010). INHIB—Test battery for response inhibition. Mödling: Schuhfried.
52. Kaller, C. P., Unterrainer, J. M., Kaiser, S., Weisbrod, M., & Aschenbrenner, S. (2012). Tower of London-Freiburg Version. Mödling: Schuhfried.
53. Koven, N. S., & Thomas, W. (2010). Mapping facets of alexithymia to executive dysfunction in daily life. Personality and Individual Differences,49, 24–28.
54. Lahera, G., Boada, L., Pousa, E., Mirapeix, I., Morón-Nozaleda, G., Marinas, L., & Parellada, M. (2014). Movie for the Assessment of Social Cognition (MASC): Spanish validation. Journal of Autism and Developmental Disorders,44, 1886–1896.
55. Lehnhardt, F. G., Falter, C. M., Gawronski, A., Pfeiffer, K., Tepest, R., Franklin, J., & Vogeley, K. (2016). Sex-related cognitive profile in autism spectrum disorders diagnosed late in life: Implications for the female autistic phenotype. Journal of Autism and Developmental Disorders,46, 139–154.
56. Lezak, M. D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.
57. Lockwood, P. L., Bird, G., Bridge, M., & Viding, E. (2013). Dissecting empathy: high levels of psychopathic and autistic traits are characterized by difficulties in different social information processing domains. Frontiers in Human Neuroscience,7, 760.
58. McEvoy, R. E., Rogers, S. J., & Pennington, B. F. (1993). Executive function and social communication deficits in young autistic children. Journal of Child Psychology and Psychiatry,34, 563–578.
59. Minio-Paluello, I., Baron-Cohen, S., Avenanti, A., Walsh, V., & Aglioti, S. M. (2009). Absence of embodied empathy during pain observation in Asperger syndrome. Biological Psychiatry,65, 55–62.
60. Montag, C., Dziobek, I., Richter, I. S., Neuhaus, K., Lehmann, A., Sylla, R., et al. (2011). Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. Psychiatry Research,186, 203–209.
61. Moriguchi, Y., Ohnishi, T., Lane, R. D., Maeda, M., Mori, T., Nemoto, K., et al. (2006). Impaired self-awareness and theory of mind: An fMRI study of mentalizing in alexithymia. Neuroimage,32, 1472–1482.
62. Nemiah, J. C., Freyberger, H., & Sifneos, P. E. (1976). Alexithymia: A view of the psychosomatic process. In O. W. Hill (Ed.), Modern trends in psychosomatic medicine (Vol. 3, pp. 430–439). London: Butterworths.
63. Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991). Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind. Journal of Child Psychology and Psychiatry,32, 1081–1105.
64. Parker, J. D. A., Taylor, G. J., & Bagby, R. M. (2003). The 20-item Toronto Alexithymia Scale: III. Reliability and factorial validity in a community population. Journal of Psychosomatic Research, 55, 269–275.
65. Pelli, D. G. (1997). The VideoToolbox software for visual psychophysics: Transforming numbers into movies. Spatial Vision,10, 437–442.
66. Pellicano, E. (2007). Links between theory of mind and executive function in young children: Clues to developmental primacy. Developmental Psychology,43, 974–990.
67. Perner, J. (1998). The meta-intentional nature of executive functions and theory of mind. In P. Carruthers & J. Boucher (Eds.), Language and thought: Interdisciplinary themes (pp. 270–283). Cambridge: Cambridge University Press.
68. Perner, J. (2000). About + belief + counterfactual. In P. Mitchell & K. Riggs (Eds.), Children’s reasoning and the mind (pp. 367–401). Hove: Psychology Press.
69. Perner, J., & Lang, B. (2000). Theory of mind and executive function: Is there a developmental relationship. In S. Baron-Cohen, T. Tager-Flusberg, & D. Cohen (Eds.), Understanding other minds: Perspectives from developmental cognitive neuroscience (2nd ed., pp. 150–181). Oxford: Oxford University Press.
70. Perner, J., Lang, B., & Kloo, D. (2002). Theory of mind and self-control: More than a common problem of inhibition. Child Development,73, 752–767.
71. Ponnet, K., Buysse, A., Roeyers, H., & De Clercq, A. (2008). Mind reading in young adults with ASD: Does structure matter? Journal of Autism and Developmental Disorders,38, 905–918.
72. Preißler, S., Dziobek, I., Ritter, K., Heekeren, H. R., & Roepke, S. (2010). Social cognition in borderline personality disorder: Evidence for disturbed recognition of the emotions, thoughts, and intentions of others. Frontiers in Behavioural Neuroscience,4, 182.
73. Premack, D., & Woodruff, G. (1978). Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences,1, 515–526.
74. Purdon, S. E. (2005). The screen for cognitive impairment in psychiatry (SCIP): administration manual and normative data. Edmonton: PNL Inc.
75. Rameson, L. T., Morelli, S. A., & Lieberman, M. D. (2012). The neural correlates of empathy: Experience, automaticity, and prosocial behavior. Journal of Cognitive Neuroscience,24, 235–245.
76. Reitan, R. M., & Wolfson, D. (1993). The Halstead Reitan Neuropsychological test battery: Theory and clinical interpretation. Tuscon, AZ: Neuropsychology Press.
77. Robinson, S., Goddard, L., Dritschel, B., Wisley, M., & Howlin, P. (2009). Executive functions in children with autism spectrum disorders. Brain and Cognition,71, 362–368.
78. Rogers, K., Dziobek, I., Hassenstab, J., Wolf, O. T., & Convit, A. (2007). Who cares? Revisiting empathy in Asperger syndrome. Journal of Autism and Developmental Disorders,37, 709–715.
79. Russell, J. (1997). How executive disorders can bring about an adequate theory of mind. In J. Russell (Ed.), Autism as an executive disorder (pp. 256–304). Oxford, England: Oxford University Press.
80. Russell, J. (2002). Cognitive theories of autism. In J. E. Harrison & A. M. Owen (Eds.), Cognitive deficits in brain disorders (pp. 295–323). London: Martin Dunitz.
81. Russo, N., Flanagan, T., Iarocci, G., Berringer, D., Zelazo, P. D., & Burack, J. A. (2007). Deconstructing executive deficits among persons with autism: Implications for cognitive neuroscience. Brain and Cognition,65, 77–86.
82. Sabbagh, M. A., Xu, F., Carlson, S. M., Moses, L. J., & Lee, K. (2006). The development of executive functioning and theory of mind: A comparison of Chinese and US preschoolers. Psychological Science,17, 74–81.
83. Schwenck, C., Mergenthaler, J., Keller, K., Zech, J., Salehi, S., Taurines, R., et al. (2012). Empathy in children with autism and conduct disorder: Group-specific profiles and developmental aspects. Journal of Child Psychology and Psychiatry,53, 651–659.
84. Seara-Cardoso, A., Craig, N., Roiser, J., McCrory, E., & Viding, E. (2012). Investigating associations between empathy, morality and psychopathic personality traits in the general population. Personality and Individual Differences,52, 67–71.
85. Shamay-Tsoory, S. G. (2011). The neural bases for empathy. Neuroscientist,17, 18–24.
86. Shamay-Tsoory, S. G., Aharon-Peretz, J., & Perry, D. (2009). Two systems for empathy: A double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain,132, 617–627.
87. Silani, G., Bird, G., Brindley, R., Singer, T., Frith, C., & Frith, U. (2008). Levels of emotional awareness and autism: An fMRI study. Social Neuroscience,3, 97–112.
88. Singer, T. (2006). The neuronal basis and ontogeny of empathy and mind reading: Review of literature and implications for future research. Neuroscience and Biobehavioral Reviews,30, 855–863.
89. Singer, T., & Lamm, C. (2009). The social neuroscience of empathy. Year in cognitive neuroscience 2009. Annals of the New York Academy of Science,1156, 81–96.
90. Smillie, L. D., Cooper, A. J., Tharp, I. J., & Pelling, E. L. (2009). Individual differences in cognitive control: The role of psychoticism and working memory in set-shifting. British Journal of Psychology,100, 629–643.
91. Smith, A. (2009). The empathy imbalance hypothesis of autism: A theoretical approach to cognitive and emotional empathy in autistic development. Psychological Record,59, 489–510.
92. Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology. Learning, Memory, and Cognition,18, 643–662.
93. Stuss, D. T., & Knight, R. T. (2002). Principles of frontal lobe function. Oxford: Oxford University Press.
94. Tantam, D. (2003). The challenge of adolescents and adults with asperger syndrome. Child Adolescence and Psychiatric Clinics of North America,12, 143–163.
95. Vetter, N. C., Altgassen, M., Phillips, L., Mahy, C. E. V., & Kliegel, M. (2013). Development of affective theory of mind across adolescence: disentangling the role of executive functions. Developmental Neuropsychology,38, 114–125.
96. von dem Hagen, E. A., Nummenmaa, L., Yu, R., Engell, A. D., Ewbank, M. P., & Calder, A. J. (2011). Autism spectrum traits in the typical population predict structure and function in the superior temporal sulcus. Cerebral Cortex,21, 493–500.
97. Wechsler, D. (1999). Wechsler Abbreviated Scale of intelligence. San Antonio, TX: The Psychological Corporation.
98. Woodbury-Smith, M. R., Robinson, J., Wheelwright, S., & Baron-Cohen, S. (2005). Screening adults for Asperger syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. Journal of Autism and Developmental Disorders,35, 331–335.