Parechovirus encephalitis and neurodevelopmental outcomes

Pediatrics

Volumn 137, Issue 2, 2016, Pages

  Britton, Philip N ^a,b,c   Dale, Russell C ^a,c   Nissen, Michael D ^d   Crawford, Nigel ^e,f,g   Elliott, Elizabeth ^a,c,h   Macartney, Kristine ^a,c,i   Khandaker, Gulam ^a,i   Booy, Robert ^a,b,c,i   Jones, Cheryl A ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^d ROYAL CHILDREN'S HOSPITAL   (Australia)

^e MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^f ROYAL CHILDREN'S HOSPITAL   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h Australian Paediatric Surveillance Unit   (Australia)

ⁱ National Centre for Immunization Research and Surveillance Sydney   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID; VIRUS RNA;

ARTICLE; ARTIFICIAL VENTILATION; AXONAL INJURY; BRAIN DEVELOPMENT; CEREBRAL PALSY; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; ECHOGRAPHY; FEMALE; HUMAN; HUMAN PARECHOVIRUS; HUMAN PARECHOVIRUS INFECTION; INFANT; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; MOTOR DEVELOPMENT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OUTCOME ASSESSMENT; PARECHOVIRUS ENCEPHALITIS; PICORNAVIRUS INFECTION; POSITIVE END EXPIRATORY PRESSURE; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RASH; SEIZURE; THALAMUS; VIRUS DETECTION; VIRUS ENCEPHALITIS; VISUAL IMPAIRMENT; WHITE MATTER; CLINICAL TRIAL; COMPLICATION; DEVELOPMENTAL DISABILITIES; ELECTROENCEPHALOGRAPHY; EXANTHEMA; FOLLOW UP; MOTOR DISORDERS; MULTICENTER STUDY; NEWBORN; PATHOLOGY; SEIZURES; VISION DISORDERS;

CEREBRAL PALSY; DEVELOPMENTAL DISABILITIES; DIFFUSION MAGNETIC RESONANCE IMAGING; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS, VIRAL; EXANTHEMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INFANT, NEWBORN; MALE; MOTOR DISORDERS; PICORNAVIRIDAE INFECTIONS; PROSPECTIVE STUDIES; SEIZURES; SURVEYS AND QUESTIONNAIRES; VISION DISORDERS; WHITE MATTER;

EID: 84958725310     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2015-2848     Document Type: Article

References (60)

1. Legay V, Chomel JJ, Fernandez E, Lina B, Aymard M, Khalfan S. Encephalomyelitis due to human parechovirus type 1. J Clin Virol. 2002;25(2):193-195
2. Benschop KS, Schinkel J, Minnaar RP, et al. Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin Infect Dis. 2006;42(2):204-210
3. Verboon-Maciolek MA, Groenendaal F, Hahn CD, et al. Human parechovirus causes encephalitis with white matter injury in neonates. Ann Neurol. 2008;64(3):266-273
4. Skram MK, Skanke LH, Krokstad S, Nordbø SA, Nietsch L, Døllner H. Severe parechovirus infection in Norwegian infants. Pediatr Infect Dis J. 2014;33(12):1222-1225
5. Kolehmainen P, Jääskeläinen A, Blomqvist S, et al. Human parechovirus type 3 and 4 associated with severe infections in young children. Pediatr Infect Dis J. 2014;33(11):1109-1113
6. Felsenstein S, Yang S, Eubanks N, Sobrera E, Grimm JP, Aldrovandi G. Human parechovirus central nervous system infections in southern California children. Pediatr Infect Dis J. 2014;33(4):e87-e91
7. Piralla A, Mariani B, Stronati M, Marone P, Baldanti F. Human enterovirus and parechovirus infections in newborns with sepsis-like illness and neurological disorders. Early Hum Dev. 2014;90(suppl 1):S75-S77
8. Levorson RE, Jantausch BA, Wiedermann BL, Spiegel HM, Campos JM. Human parechovirus-3 infection: emerging pathogen in neonatal sepsis. Pediatr Infect Dis J. 2009; 28(6):545-547
9. Harvala H, Robertson I, Chieochansin T, McWilliam Leitch EC, Templeton K, Simmonds P. Specific association of human parechovirus type 3 with sepsis and fever in young infants, as identified by direct typing of cerebrospinal fluid samples. J Infect Dis. 2009;199(12):1753-1760
10. Piñeiro L, Vicente D, Montes M, Hernández-Dorronsoro U, Cilla G. Human parechoviruses in infants with systemic infection. J Med Virol. 2010;82(10):1790-1796
11. Selvarangan R, Nzabi M, Selvaraju SB, Ketter P, Carpenter C, Harrison CJ. Human parechovirus 3 causing sepsis-like illness in children from midwestern United States. Pediatr Infect Dis J. 2011; 30(3):238-242
12. Harvala H, McLeish N, Kondracka J, et al. Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in Edinburgh: HPeV type 3 identified as the most common picornavirus type. J Med Virol. 2011;83(5):889-896
13. Walters B, Peñaranda S, Nix WA, et al. Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area. J Clin Virol. 2011;52(3):187-191
14. Schuffenecker I, Javouhey E, Gillet Y, et al. Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases. J Clin Virol. 2012;54(4):337-341
15. Fischer TK, Midgley S, Dalgaard C, Nielsen AY. Human parechovirus infection, Denmark. Emerg Infect Dis. 2014;20(1):83-87
16. Sharp J, Harrison CJ, Puckett K, et al. Characteristics of young infants in whom human parechovirus, enterovirus or neither were detected in cerebrospinal fluid during sepsis evaluations. Pediatr Infect Dis J. 2013;32(3):213-216
17. Han TH, Chung JY, You SJ, Youn JL, Shim GH. Human parechovirus-3 infection in children, South Korea. J Clin Virol. 2013;58(1):194-199
18. Ghanem-Zoubi N, Shiner M, Shulman LM, et al. Human parechovirus type 3 central nervous system infections in Israeli infants. J Clin Virol. 2013;58(1):205-210
19. Vanagt WY, Lutgens SP, van Loo IH, Wolffs PF, van Well GT. Paediatric sepsis-like illness and human parechovirus. Arch Dis Child. 2012;97(5):482-483
20. Wolthers KC, Benschop KS, Schinkel J, et al. Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children. Clin Infect Dis. 2008;47(3):358-363
21. Abed Y, Boivin G. Human parechovirus types 1, 2 and 3 infections in Canada. Emerg Infect Dis. 2006;12(6):969-975
22. Piralla A, Furione M, Rovida F, et al. Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010. J Med Virol. 2012;84(4):686-690
23. Rahimi P, Naser HM, Siadat SD, et al. Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness. J Neurovirol. 2013;19(6):595-600
24. Zhong H, Lin Y, Su L, Cao L, Xu M, Xu J. Prevalence of human parechoviruses in central nervous system infections in children: A retrospective study in Shanghai, China. J Med Virol. 2013;85(2):320-326
25. Harvala H, Griffiths M, Solomon T, Simmonds P. Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. J Infect. 2014;69(1):69-74
26. Brownell AD, Reynolds TQ, Livingston B, McCarthy CA. Human parechovirus-3 encephalitis in two neonates: acute and follow-up magnetic resonance imaging and evaluation of central nervous system markers of inflammation. Pediatr Neurol. 2015;52(2):245-249
27. Gupta S, Fernandez D, Siddiqui A, Tong WC, Pohl K, Jungbluth H. Extensive white matter abnormalities associated with neonatal parechovirus (HPeV) infection. Eur J Paediatr Neurol. 2010;14(6):531-534
28. Glaser CA, Honarmand S, Anderson LJ, et al. Beyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis. 2006;43(12):1565-1577
29. Granerod J, Ambrose HE, Davies NW, et al; UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group. Causes of encephalitis and differences in their clinical presentations in England: A multicentre, populationbased prospective study [published correction appears in Lancet Infect Dis. 2011;11(2):79]. Lancet Infect Dis. 2010;10(12):835-844
30. Mailles A, Stahl J-P; Steering Committee and Investigators Group. Infectious encephalitis in France in 2007: A national prospective study. Clin Infect Dis. 2009;49(12):1838-1847
31. Sejvar JJ, Kohl KS, Bilynsky R, et al; Brighton Collaboration Encephalitis Working Group. Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine. 2007;25(31):5771-5792
32. Venkatesan A, Tunkel AR, Bloch KC, et al; International Encephalitis Consortium. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013;57(8):1114-1128
33. Zurynski Y, McIntyre P, Booy R, Elliott EJ; PAEDS Investigators Group. Paediatric active enhanced disease surveillance: A new surveillance system for Australia. J Paediatr Child Health. 2013;49(7):588-594
34. Khatami A, McMullan BJ, Webber M, et al. Sepsis-like disease in infants due to human parechovirus type 3 during an outbreak in Australia. Clin Infect Dis. 2015;60(2):228-236
35. Papadakis G, Chibo D, Druce J, Catton M, Birch C. Detection and genotyping of enteroviruses in cerebrospinal fluid in patients in Victoria, Australia, 2007-2013. J Med Virol. 2014;86(9):1609-1613
36. Benschop K, Molenkamp R, van der Ham A, Wolthers K, Beld M. Rapid detection of human parechoviruses in clinical samples by real-time PCR. J Clin Virol. 2008;41(2):69-74
37. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1(7905):480-484
38. Cumming G, Khatami A, McMullan BJ, et al. Parechovirus genotype 3 outbreak among infants, New South Wales, Australia, 2013-2014. Emerg Infect Dis. 2015;21(7):1144-1152
39. Cooper MS, van Schilfgaarde KD, De Mel GR, Rajapaksa S. Identification of human parechovirus-3 in young infants within rural Victoria. J Paediatr Child Health. 2014;50(9):746-747
40. Verboon-Maciolek MA, Krediet TG, Gerards LJ, de Vries LS, Groenendaal F, van Loon AM. Severe neonatal parechovirus infection and similarity with enterovirus infection. Pediatr Infect Dis J. 2008;27(3):241-245
41. Belcastro V, Bini P, Barachetti R, Barbarini M. Teaching neuroimages: neonatal parechovirus encephalitis: typical MRI findings. Neurology. 2014;82(3):e23
42. Wu T, Fan XP, Wang WY, Yuan TM. Enterovirus infections are associated with white matter damage in neonates. J Paediatr Child Health. 2014;50(10):817-822
43. Verboon-Maciolek MA, Groenendaal F, Cowan F, Govaert P, van Loon AM, de Vries LS. White matter damage in neonatal enterovirus meningoencephalitis. Neurology. 2006;66(8):1267-1269
44. Back SA. Perinatal white matter injury: The changing spectrum of pathology and emerging insights into pathogenetic mechanisms. Ment Retard Dev Disabil Res Rev. 2006;12(2):129-140
45. Woodward LJ, Anderson PJ, Austin NC, Howard K, Inder TE. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Engl J Med. 2006;355(7):685-694
46. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008;93(2):F153-F161
47. Kadhim H, Sebire G. Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes. Eur J Paediatr Neurol. 2002;6(3):139-142
48. Kadhim H, Tabarki B, Verellen G, De Prez C, Rona AM, Sébire G. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology. 2001;56(10):1278-1284
49. Volpe JJ. Neonatal encephalitis and white matter injury: more than just inflammation? Ann Neurol. 2008;64(3):232-236
50. Westerhuis BM, Koen G, Wildenbeest JG, et al. Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development. J Gen Virol. 2012;93(pt 11):2363-2370
51. Sedmak G, Nix WA, Jentzen J, et al. Infant deaths associated with human parechovirus infection in Wisconsin. Clin Infect Dis. 2010;50(3):357-361
52. van Zwol AL, Lequin M, Aarts-Tesselaar C, et al Fatal neonatal parechovirus encephalitis. BMJ Case Rep. 2009;2009
53. Pillai SC, Hacohen Y, Tantsis E, et al. Infectious and autoantibody-associated encephalitis: clinical features and longterm outcome. Pediatrics. 2015;135(4). Available at: www.pediatrics.org/cgi/content/full/135/4/e974
54. Wong AM, Lin JJ, Toh CH, et al. Childhood encephalitis: relationship between diffusion abnormalities and clinical outcome. Neuroradiology. 2015;57(1):55-62
55. Neilson DE, Adams MD, Orr CM, et al. Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet. 2009;84(1):44-51
56. Casrouge A, Zhang SY, Eidenschenk C, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science. 2006;314(5797):308-312
57. Wildenbeest JG, Harvala H, Pajkrt D, Wolthers KC. The need for treatment against human parechoviruses: how, why and when? Expert Rev Anti Infect Ther. 2010;8(12):1417-1429
58. Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol. 2010;9(11):1097-1105
59. Dale RC, Brilot F. Biomarkers of inflammatory and auto-immune central nervous system disorders. Curr Opin Pediatr. 2010;22(6):718-725
60. Aizawa Y, Yamanaka T, Watanabe K, Oishi T, Saitoh A. Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants. J Clin Virol. 2015;70:105-108