Serum progranulin irrelated with Breg cell levels, but elevated in RA patients, reflecting high disease activity

Rheumatology International

Volumn 36, Issue 3, 2016, Pages 359-364

  Chen, Jiaxi ^a   Li, Shuang ^a   Shi, Jianfeng ^a   Zhang, Lili ^a   Li, Jun ^a   Chen, Shiyong ^a   Wu, Chunlong ^a   Shen, Bo ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Progranulin; Regulatory subsets of B cells; Rheumatoid arthritis

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GRANZYME B; PROGRANULIN; CD19 ANTIGEN; CD5 ANTIGEN; GRANZYME; GRN PROTEIN, HUMAN; GZMB PROTEIN, HUMAN; SIGNAL PEPTIDE;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL EVALUATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DAS28; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNITY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; RHEUMATOID ARTHRITIS; AREA UNDER THE CURVE; ARTHRITIS, RHEUMATOID; BLOOD; CASE CONTROL STUDY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MIDDLE AGED; PHENOTYPE; PREDICTIVE VALUE; PROCEDURES; REGULATORY B LYMPHOCYTE; SEVERITY OF ILLNESS INDEX; UPREGULATION;

ADULT; ANTIGENS, CD19; ANTIGENS, CD5; AREA UNDER CURVE; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES, REGULATORY; BIOMARKERS; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRANZYMES; HUMANS; IMMUNOPHENOTYPING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHENOTYPE; PREDICTIVE VALUE OF TESTS; ROC CURVE; SEVERITY OF ILLNESS INDEX; UP-REGULATION;

EID: 84958680697     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-015-3372-4     Document Type: Article

References (27)

1. Tang W, Lu Y, Tian QY et al (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332(6028):478–484
2. Liu CJ (2011) Progranulin: a promising therapeutic target for rheumatoid arthritis. FEBS Lett 585(23):3675–3680
3. Chen X, Baumel M, Mannel DN et al (2007) Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4 + CD25 + T regulatory cells. J Immunol 179:154–161
4. Chopra M, Riedel SS, Biehl M et al (2013) Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34:1296–1303
5. Housley WJ, Adams CO, Nichols FC et al (2011) Natural but not inducible regulatory T cells require TNF- a signaling for in vivo function. J Immunol. 186:6779–6787
6. Iwata Y, Matsushita T, Horikawa M et al (2011) Characterization of a rare IL-10 competent B cell subset in humans that parallels mouse regulatory B10 cells. Blood 117:530–541
7. Yang M, Rui K, Wang S et al (2013) Regulatory B cells in autoimmune diseases. Cell Mol Immunol 10(2):122–132
8. Lindner S, Dahlke K, Sontheimer K et al (2013) Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res 73(8):2468–2469
9. Arnett FC, Edworthy SM, Bloch DA et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324
10. Prevoo ML, Van’t Hof MA, Kuper HH et al (1995) Modified disease activity scores that includes twenty-eight joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38(1):44–48
11. Jian J, Zhao S, Tian Q et al (2013) Progranulin directly binds to theCRD2 and CRD3 of TNFR extracellular domains. FEBS Lett 587(21):3428–3436
12. Guo Z, Li Q, Han Y et al (2012) Prevention of LPS-induced acute lung injury in mice by progranulin. Mediat Inflamm 2012:540794
13. Egashira Y, Suzuki Y, Azuma Y et al (2013) The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. J Neuroinflamm 10:105
14. Kawase R, Ohama T, Matsuyama A et al (2013) Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. Cardiovasc Res 100(1):125–133
15. Thurner L, Zaks M, Preuss KD et al (2013) Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis. Arthritis Res Ther 15(6):R211
16. Ravi B, Escott B, Shah PS et al (2012) A systematic review and meta-analysis comparing complications following total joint arthroplasty for rheumatoid arthritis versus for osteoarthritis. Arthritis Rheum 64(12):3839–3849
17. Guo F, Lai Y, Tian Q et al (2010) Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilageoligomeric matrix protein. Arthritis Rheum 62(7):2023–2036
18. Yamamoto Y, Takemura M, Serrero G et al (2014) Increased serum GP88 (progranulin) concentrations in rheumatoid arthritis. Inflammation 37(5):1806–1813
19. Ghidoni R, Benussi L, Glionna M et al (2008) Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration. Neurology 71(16):1235–1239
20. Tanaka A, Tsukamoto H, Mitoma H et al (2015) Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis. Arthritis Res Ther 10(17):27
21. Tanaka A, Tsukamoto H, Mitoma H et al (2012) Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity. Arthritis Res Ther 14(6):R244
22. Antonell A, Gil S, Sánchez-Valle R et al (2012) Serum progranulin levels in patients with frontotemporal lobar degeneration and Alzheimer’s disease: detection of GRN mutations in a Spanish cohort. J Alzheimers Dis 31(3):581–591
23. He Z, Ong CH, Halper J, Bateman A (2003) Progranulin is a mediator of the wound response. Nat Med 9:225–229
24. Chen X, Oppenheim JJ (2011) Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity. FEBS Lett 585:3611–3618
25. Zhao YP, Tian QY, Liu CJ (2013) Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice. FEBS Lett 587:1805–1810
26. Mizoguchi A, Bhan AK (2006) A case for regulatory B cells. J Immunol 176(2):705–710
27. Cui D, Zhang L, Chen J et al (2015) Changes in regulatory B cells and their relationship with rheumatoid arthritis disease activity. Clin Exp Med 15(3):285–292