Pioglitazone up-regulates long non-coding RNA MEG3 to protect endothelial progenitor cells via increasing HDAC7 expression in metabolic syndrome

Biomedicine and Pharmacotherapy

Volumn 78, Issue , 2016, Pages 101-109

  Liu, H Z ^a   Wang, Q Y ^a   Zhang, Y ^a   Qi, D T ^a   Li, M W ^a   Guo, W Q ^a   Ma, Y H ^a   Wang, L Y ^a   Chen, Y ^a   Gao, C Y ^a  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Endothelial progenitor cells; HDAC7; LncRNA; Metabolic syndrome; MiR 140

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HISTONE DEACETYLASE 7; LONG UNTRANSLATED RNA; MATERNALLY EXPRESSED 3; MICRORNA; MICRORNA 140-5P; PALMITIC ACID; PIOGLITAZONE; RNA BINDING PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCOSE BLOOD LEVEL; HDAC7 PROTEIN, HUMAN; HISTONE DEACETYLASE; LIPID; MEG3 NON-CODING RNA, HUMAN; MIRN140 MICRORNA, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL PROGENITOR CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID BLOOD LEVEL; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BLOOD; BONE MARROW; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PATHOLOGY;

ANIMALS; BLOOD GLUCOSE; BONE MARROW; CELL COUNT; CYTOPROTECTION; DOWN-REGULATION; ENDOTHELIAL PROGENITOR CELLS; HISTONE DEACETYLASES; HUMANS; LIPIDS; MALE; METABOLIC SYNDROME X; MICE, INBRED C57BL; MICRORNAS; RNA, LONG NONCODING; THIAZOLIDINEDIONES; UP-REGULATION;

EID: 84958678823     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.01.001     Document Type: Article

References (28)

1. Grundy S.M. Metabolic syndrome pandemic. Arterioscler. Thromb. Vasc. Biol. 2008, 28(4):629-636.
2. Mottillo S., et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J. Am. Coll. Cardiol. 2010, 56(14):1113-1132.
3. Devaraj S., Jialal I. Dysfunctional endothelial progenitor cells in metabolic syndrome. Exp. Diabetes Res. 2012, 2012:585018.
4. Jialal I., et al. Circulating levels of endothelial progenitor cell mobilizing factors in the metabolic syndrome. Am. J. Cardiol. 2010, 106(11):1606-1608.
5. Lincoff A.M., et al. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 2007, 298(10):1180-1188.
6. Rajagopalan R., Iyer S., Khan M. Effect of pioglitazone on metabolic syndrome risk factors: results of double-blind, multicenter, randomized clinical trials. Curr. Med. Res. Opin. 2005, 21(1):163-172.
7. Spigoni V., et al. Pioglitazone improves in vitro viability and function of endothelial progenitor cells from individuals with impaired glucose tolerance. PLoS One 2012, 7(11):e48283.
8. Wang C.H., et al. Pioglitazone increases the numbers and improves the functional capacity of endothelial progenitor cells in patients with diabetes mellitus. Am. Heart J. 2006, 152(6):1051. e1-8.
9. Zhang H.F., et al. PPAR-gamma agonist pioglitazone prevents apoptosis of endothelial progenitor cells from rat bone marrow. Cell Biol. Int. 2013, 37(5):430-435.
10. Mercer T.R., Dinger M.E., Mattick J.S. Long non-coding RNAs: insights into functions. Nat. Rev. Genet. 2009, 10(3):155-159.
11. Macfarlane L.A., Murphy P.R. MicroRNA: biogenesis, function and role in cancer. Curr. Genomics 2010, 11(7):537-561.
12. Nie F.Q., et al. Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. Tumour. Biol. 2014, 35(8):7587-7594.
13. Michalik K.M., et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ. Res. 2014, 114(9):1389-1397.
14. Gordon F.E., et al. Increased expression of angiogenic genes in the brains of mouse meg3-null embryos. Endocrinology 2010, 151(6):2443-2452.
15. Ortega F.J., et al. Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes Care 2014, 37(5):1375-1383.
16. Ortega F.J., et al. Targeting the circulating microRNA signature of obesity. Clin. Chem. 2013, 59(5):781-792.
17. Jialal I., et al. Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk. Atherosclerosis 2010, 211(1):297-302.
18. Chiang C.H., et al. Decreased circulating endothelial progenitor cell levels and function in patients with nonalcoholic fatty liver disease. PLoS One 2012, 7(2):e31799.
19. Tsai T.H., et al. Obesity suppresses circulating level and function of endothelial progenitor cells and heart function. J. Transl. Med. 2012, 10:137.
20. Fadini G.P., et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J. Am. Coll. Cardiol. 2005, 45(9):1449-1457.
21. Zhou Y., Zhang X., Klibanski A. MEG3 noncoding RNA: a tumor suppressor. J. Mol. Endocrinol. 2012, 48(3):R45-53.
22. Wang F., et al. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget 2015.
23. Urbich C., et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 2009, 113(22):5669-5679.
24. Mottet D., et al. Histone deacetylase 7 silencing alters endothelial cell migration: a key step in angiogenesis. Circ. Res. 2007, 101(12):1237-1246.
25. Wang S., et al. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(22):7738-7743.
26. Yu D., et al. VEGF-PKD1-HDAC7 signaling promotes endothelial progenitor cell migration and tube formation. Microvas. Res. 2014, 91:66-72.
27. Swierczynski S., et al. Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases. Expert Opin. Biol. Ther. 2015, 15(5):651-664.
28. Kai Y., et al. Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells. Biochem. Biophys. Res. Commun. 2014, 448(3):308-314.