Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative

Psychophysiology

Volumn 53, Issue 3, 2016, Pages 312-322

  Hamm, Alfons O ^a   Richter, Jan ^a   Pané Farré, Christiane ^a   Westphal, Dorte ^b   Wittchen, Hans Ulrich ^b   Vossbeck Elsebusch, Anna N ^c   Gerlach, Alexander L ^d   Gloster, Andrew T ^e   Ströhle, Andreas ^f   Lang, Thomas ^g   Kircher, Tilo ^h   Gerdes, Antje B M ⁱ   Alpers, Georg W ⁱ   Reif, Andreas ^j   Deckert, Jürgen ^k  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF BASEL   (Switzerland)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g Christoph Dornier Foundation for Clinical Psychology   (Germany)

^h PHILIPPS UNIVERSITY MARBURG   (Germany)

ⁱ UNIVERSITY OF MANNHEIM   (Germany)

^j GOETHE UNIVERSITY   (Germany)

^k UNIVERSITY OF WÜRZBURG   (Germany)

more..

Author keywords

Anxiety; Autonomic; Genetics; Psychopathological; Psychopathology; Startle Blink

Indexed keywords

AGORAPHOBIA; ANIMAL; AVOIDANCE BEHAVIOR; BIOLOGICAL MODEL; CLINICAL TRIAL (TOPIC); DEFENSE MECHANISM; FEMALE; HUMAN; MALE; MULTICENTER STUDY (TOPIC); NEUROSCIENCE; PANIC DISORDER; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RISK FACTOR; STARTLE REFLEX;

AGORAPHOBIA; ANIMALS; AVOIDANCE LEARNING; CLINICAL TRIALS AS TOPIC; DEFENSE MECHANISMS; FEMALE; HUMANS; MALE; MODELS, NEUROLOGICAL; MULTICENTER STUDIES AS TOPIC; NEUROSCIENCES; PANIC DISORDER; REFLEX, STARTLE; RISK FACTORS;

EID: 84958620809     PISSN: 00485772     EISSN: 14698986     Source Type: Journal    
DOI: 10.1111/psyp.12553     Document Type: Article

References (78)

1. Alius, M. G., Pané-Farré, C. A., Von Leupoldt, A., & Hamm, A. O. (2013). Induction of dyspnea evokes increased anxiety and maladaptive breathing in individuals with high anxiety sensitivity and suffocation fear. Psychophysiology, 50, 488-497. doi: 10.1111/psyp.12028
2. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders, 3th ed., rev., DSM-III-R. Arlington, VA: Author.
3. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 4th ed., text rev., DSM-IV-TR. Arlington, VA: Author.
4. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, 5th ed., DSM-5. Arlington, VA: Author.
5. Arrindell, W. A., Cox, B. J., Van der Ende, J., & Kwee, M. G. (1995). Phobic dimensions-II. Cross-national confirmation of the multidimensional structure underlying the Mobility Inventory (MI). Behaviour Research and Therapy, 33, 711-724. doi: 10.1016/0005-7967(95)00002-F
6. Beck, A. T., & Emery, G. (1985). Anxiety disorders and phobias: A cognitive perspective. New York: Basic Books.
7. Beninger, R. J. (1989). The role of serotonin and dopamine in learning to avoid aversive stimuli. In T. Archer & L.-G. Nilsson (Eds.), Aversion, avoidance, and anxiety: Perspectives on aversively motivated behavior (pp. 265-288). Hillsdale, NJ: Erlbaum.
8. Blanchard, D. C. (1997). Stimulus, environmental, and pharmacological control of defensive behaviors. In M. E. Bouton & M. S. Fanselow (Eds.), Learning, motivation, and cognition: The functional behaviorism of Robert C. Bolles (pp. 283-303). Washington, DC: American Psychological Association.
9. Bouton, M. E., Mineka, S., & Barlow, D. H. (2001). A modern learning theory perspective on the etiology of panic disorder. Psychological Review, 108, 4-32. doi: 10.1037/0033-295x.108.1.4
10. Campbell, B. A., Wood, G., & McBride, T. (1997). Origins of orienting and defensive responses: An evolutionary perspective. In P. J. Lang, R. F. Simons, & M. T. Balaban (Eds.), Attention and orienting: Sensory and motivational processes (pp. 41-67). Hillsdale, NJ: Erlbaum.
11. Cannon, W. B. (1932). The wisdom of the body. New York: Norton.
12. Canteras, N. S., & Graeff, F. G. (2014). Executive and modulatory circuits of defensive reactions: Implications for panic disorder. Neuroscience and Biobehavioral Reviews, 46, 352-364. doi: 10.1016/j.neubiorev.2014.03.020
13. Cohen, A. S., Barlow, D. H., & Blanchard, E. B. (1985). The psychophysiology of relaxation-associated panic attacks. Journal of Abnormal Psychology, 94, 96-101. doi: 10.1037/0021-843x.94.1.96
14. Cox, B. J., Swinson, R. P., Kuch, K., & Reichman, J. T. (1993). Dimensions of agoraphobia assessed by the Mobility Inventory. Behaviour Research and Therapy, 31, 427-431. doi: 10.1016/0005-7967(93)90102-z
15. Craske, M. G. (1999). Anxiety disorders: Psychological approaches to theory and treatment. New York: Basic Books.
16. Craske, M. G., Rapee, R. M., & Barlow, D. H. (1988). The significance of panic-expectancy for individual patterns of avoidance. Behavior Therapy, 19, 577-592. doi: 10.1016/s0005-7894(88)80025-x
17. Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11, 126. doi: 10.1186/1741-7015-11-126
18. Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010). Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology, 35, 105-135. doi: 10.1038/npp.2009.109
19. Davis, M., & Whalen, P. J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6, 13-34. doi: 10.1038/sj.mp.4000812
20. Deckert, J., Catalano, M., Syagailo, Y. V., Bosi, M., Okladnova, O., Di Bella, D., ... & Lesch, K. P. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics, 8, 621-624. doi: 10.1093/hmg/8.4.621
21. Domschke, K., Reif, A., Weber, H., Richter, J., Hohoff, C., Ohrmann, P., ... & Deckert, J. (2010). Neuropeptide S receptor gene-Converging evidence for a role in panic disorder. Molecular Psychiatry, 16, 938-948. doi: 10.1038/mp.2010.81
22. Fanselow, M. S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin & Review, 1, 429-438. doi: 10.3758/bf03210947
23. Gloster, A. T., Hauke, C., Höfler, M., Einsle, F. Fydrich, T., Hamm, A., Ströhle, A., & Wittchen, H.-U. (2013). Long-term stability of cognitive behavioral therapy effects of panic disorder with agoraphobia: A two-year follow-up study. Behaviour Research and Therapy, 51, 830-839. doi: 10.1016/j.brat.2013.09.009
24. Gloster, A. T., Klotsche, J., Gerlach, A. L., Hamm, A., Ströhle, A., Gauggel, S., ... & Wittchen, H.-U. (2014). Timing matters: change depends on the stage of treatment in cognitive behavioral therapy for panic disorder with agoraphobia. Journal of Consulting and Clinical Psychology. 82, 141-153. doi: 10.1037/a0034555
25. Gloster, A. T., Wittchen, H.-U., Einsle, F., Höfler, M., Lang, T., Helbig-Lang, S., ... & Arolt, V. (2009). Mechanisms of action in CBT (MAC): Methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. European Archives of Psychiatry and Clinical Neuroscience, 259, 155-166. doi: 10.1007/s00406-009-0065-6
26. Gloster, A. T., Wittchen, H.-U., Einsle, F., Lang, T., Helbig-Lang, S., Fydrich, T., ... & Arolt, V. (2011). Psychological treatment for panic disorder with agoraphobia: A randomized controlled trial to examine the role of therapist-guided exposure in-situ in CBT. Journal of Consulting and Clinical Psychology, 79, 406-420. doi: 10.1037/a0023584
27. Hamm, A. O., Richter, J., & Pané-Farré, C. A. (2014). When the threat comes from inside the body: A neuroscience based learning perspective of the etiology of panic disorder. Restorative Neurology and Neuroscience, 32, 79-93. doi: 10.3233/RNN-139011
28. Hamm, A. O., & Weike, A. I. (2005). The neuropsychology of fear learning and fear regulation. International Journal of Psychophysiology, 57, 5-14. doi: 10.1016/j.ijpsycho.2005.01.006
29. Hohoff, C., Weber, H., Richter, J., Domschke, K., Zwanzger, P. M., Ohrmann, P., ... & Deckert, J. (2015). RGS2 genetic variation: Association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 168, 211-222. doi: 10.1002/ajmg.b.32299
30. Kim, E. J., Horovitz, O., Pellman, B. A., Tan, L. M., Li, Q., Richter-Levin, G., & Kim, J. J. (2013). Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats. Proceedings of the National Academy of Sciences, 110, 14795-14800. doi: 10.1073/pnas.1310845110
31. Klein, D. F. (1993). False suffocation alarms, spontaneous panics, and related conditions: An integrative hypothesis. Archives of General Psychiatry, 50, 306-317. doi: 10.1001/archpsyc.1993.01820160076009
32. Kozak, M. J., & Cuthbert, B. N. (2016). The NIMH Research Domain Criteria initiative: Background, issues, and pragmatics. Psychophysiology, 53, 286-297.
33. Kwon, S. M., Evans, L., & Oei, T. P. (1990). Factor structure of the Mobility Inventory for agoraphobia: A validational study with Australian samples of agoraphobic patients. Journal of Psychopathology and Behavioral Assessment, 12, 365-374. doi: 10.1007/bf00965990
34. Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1997). Motivated attention: Affect, activation, and action. In P. J. Lang, R. F. Simons, & M. T. Balaban (Eds.), Attention and orienting: Sensory and motivational processes (pp. 97-135). Hillsdale NJ: Erlbaum.
35. Lang, P. J., Davis, M., & Öhman, A. (2000). Fear and anxiety: Animal models and human cognitive psychophysiology. Journal of Affective Disorders, 61, 137-159. doi: 10.1016/s0165-0327(00)00343-8
36. LeDoux, J. (2012). Rethinking the emotional brain. Neuron, 73, 653-676. doi: 10.1016/j.neuron.2012.02.018
37. Ley, R. (1985). Blood, breath, and fears: A hyperventilation theory of panic attacks and agoraphobia. Clinical Psychology Review, 5, 271-285. doi: 10.1016/0272-7358(85)90008-x
38. Löw, A., Lang, P. J., Smith, J. C., & Bradley, M. M. (2008). Both predator and prey emotional arousal in threat and reward. Psychological Science, 19, 865-873. doi: 10.1111/j.1467-9280.2008.02170.x
39. Löw, A., Weymar, M., & Hamm, A. O. (in press). When threat is near get out of here: Dynamic of defensive behavior during freezing and escape. Psychological Science.
40. Maren, S. (2001). Neurobiology of Pavlovian fear conditioning. Annual Review of Neuroscience, 24, 897-931. doi: 10.1146/annurev.neuro.24.1.897
41. Maron, E., Lang, A., Tasa, G., Liivlaid, L., Toru, I., Must, A., ... & Shlik, J. (2005). Associations between serotonin-related gene polymorphisms and panic disorder. The International Journal of Neuropsychopharmacology, 8, 261-266. doi: 10.1017/s1461145704004985
42. McNally, R. J. (1994). Panic disorder: A critical analysis. New York: Guilford.
43. McTeague, L. M., Lang, P. J., Laplante, M.-C., & Bradley, M. M. (2011). Aversive imagery in panic disorder: Agoraphobia, severity, comorbidity, and defensive physiology. Biological Psychiatry, 70, 415-424. doi: 10.1016/j.biopsych.2011.03.005
44. Melzig, C. A., Holtz, K., Michalowski, J. M., & Hamm, A. O. (2011). Interoceptive threat leads to defensive mobilization in highly anxiety sensitive persons. Psychophysiology, 48, 745-754. doi: 10.1111/j.1469-8986.2010.01150.x
45. Meuret, A. E., Rosenfield, B., Wilhelm, F. H., Zhou, E., Conrad, A., Ritz, T., & Roth, W. T. (2012). Do unexpected panic attacks occur spontaneously? Biological Psychiatry, 70, 985-991. doi: 10.1016/j.biopsych.2011.05.027
46. Michalowski, J. M., Melzig, C. A., Stockburger, J., Schupp, H. T., & Hamm, A. O. (2009). Brain dynamics of spider-phobic individuals exposed to phobia-relevant and other emotional stimuli. Emotion, 9, 306-315. doi: 10.1037/a0015550
47. Michalowski, J. M., Pané-Farré, C. A., Löw, A., & Hamm, A. O. (2015). Brain dynamics of visual attention during anticipation and encoding of threat- and safe cues in spider phobic individuals. Social Cognitive and Affective Neuroscience, 10, 1177-1186. doi: 10.1092/scan/nsv002
48. Miller, H. E. J., Deakin, J. F. W., & Anderson, I. M. (2000). Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers. The British Journal of Psychiatry, 176, 182-188. doi: 10.1192/bjp.176.2.182
49. Morgan, M. M., & Carrive, P. (2001). Activation of the ventrolateral periaqueductal gray reduces locomotion but not mean arterial pressure in awake, freely moving rats. Neuroscience, 102, 905-910. doi: 10.1016/s0306-4522(00)00513-3
50. Naragon-Gainey, K. (2010). Meta-analysis of the relations of anxiety sensitivity to the depressive and anxiety disorders. Psychological Bulletin, 136, 128-150. doi: 10.1037/a0018055
51. Nashold, B. S. Jr., Wilson, W. P., & Slaughter, G. S. (1974). The midbrain and pain. In J. J. Bonica (Ed.), Advances in neurology, Vol 4 (pp. 191-196). New York: Raven Press.
52. Öst, L. G., Johansson, J., & Jerremalm, A. (1982). Individual response patterns and the effects of different behavioral methods in the treatment of claustrophobia. Behaviour Research and Therapy, 20, 445-460. doi: 10.1016/0005-7967(82)90066-3
53. Otto, M. W., Pollack, M. H., & Maki, K. M. (2000). Empirically supported treatments for panic disorder: Costs, benefits, and stepped care. Journal of Consulting and Clinical Psychology, 68, 556-563. doi: 10.1037/0022-006x.68.4.556
54. Pané-Farré, C. A., Fenske, K., Stender, J. P., Meyer, C., John, U., Rumpf, H. J., ... Hamm, A. O. (2013). Sub-threshold panic attacks and agoraphobic avoidance increase comorbidity of mental disorders: Results from an adult general population sample. Journal of Anxiety Disorders, 27, 485-493. doi: 10.1016/j.janxdis.2013.06.008
55. Pané-Farré, C. A., Stender, J. P., Fenske, K., Deckert, J., Reif, A. John, U., ... & Hamm, A. O. (2014). The phenomenology of the first panic attack in clinical and community based samples. Journal of Anxiety Disorders, 28, 522-528. doi: 10.1016/j.janxdis.2014.05.009
56. Preter, M., & Klein, D. F. (2008). Panic, suffocation false alarms, separation anxiety and endogenous opioids. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32, 603-612.
57. Rachman, S., Levitt, K., & Lopatka, C. (1988). Experimental analyses of panic-III-claustrophobic subjects. Behaviour Research and Therapy, 26, 41-52. doi: 10.1016/0005-7967(88)90032-0
58. Rachman, S., & Taylor, S. (1993). Analyses of claustrophobia. Journal of Anxiety Disorders, 7, 281-291. doi: 10.1016/0887-6185(93)90025-g
59. Radomsky, A. S., Rachman, S., Thordarson, D. S., McIsaac, H. K., & Teachman, B. A. (2001). The claustrophobia questionnaire. Journal of Anxiety Disorders, 15, 287-297. doi: 10.1016/j.pnpbp.2007.07.029
60. Reif, A., Richter, J., Straube, B., Höfler, M., Lueken, U., Gloster, A. T., ... & Deckert, J. (2014). MAOA and mechanisms of panic disorder revisited: From bench to molecular psychotherapy. Molecular Psychiatry, 19, 122-128. doi: 10.1038/mp.2012.172
61. Reiss, S. (1991). Expectancy model of fear, anxiety, and panic. Clinical Psychology Review, 11, 141-153. doi: 10.1016/0272-7358(91)90092-9
62. Reiss, S., Peterson, R. A., Gursky, D. M., & McNally, R. J. (1986). Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behaviour Research and Therapy, 24, 1-8. doi: 10.1016/0005-7967(86)90143-9
63. Rescorla, R. A., & Wagner, A. (1972). A theory of Pavlovian conditioning: Variations in the effectiveness of reinforcement and nonreinforcement. In A. H. Black & W. F. Prokasy (Eds.), Classical conditioning II: Current research and theory (pp. 64-99). New York: Appleton-Century-Crofts.
64. Richter, J., Hamm, A. O., Pané-Farré, C. A., Gerlach, A. L., Gloster, A. T., Wittchen, H. U., ... & Arolt, V. (2012). Dynamics of defensive reactivity in patients with panic disorder and agoraphobia: Implications for the etiology of panic disorder. Biological Psychiatry, 72, 512-520. doi: 10.1016/j.biopsych.2012.03.035
65. Rodriguez, B. F., Pagano, M. E., & Keller, M. B. (2007). Psychometric characteristics of the Mobility Inventory in a longitudinal study of anxiety disorders: Replicating and exploring a three-component solution. Journal of Anxiety Disorders, 21, 752-761. doi: 10.1016/j.janxdis.2006.08.008
66. Samochowiec, J., Hajduk, A., Samochowiec, A., Horodnicki, J., Stepień, G., Grzywacz, A., & Kucharska-Mazur, J. (2004). Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Research, 128, 21-26. doi: 10.1016/j.psychres.2004.05.012
67. Sánchez-Meca, J., Rosa-Alcázar, A. I., Marin-Martinez, F., & Gómez-Conesa, A. (2010). Psychological treatment of panic disorder with or without agoraphobia: A meta-analysis. Clinical Psychology Review, 30, 37-50. doi: 10.1016/j.cpr.2009.08.011
68. Schenberg, L. C., Schimitel, F. G., de Souza Armini, R., Bernabé, C. S., Rosa, C. A., Tufik, S., ... & Quintino-dos-Santos, J. W. (2014). Translational approach to studying panic disorder in rats: Hits and misses. Neuroscience & Biobehavioral Reviews, 46, 472-496. doi: 10.1016/j.neubiorev.2014.10.002
69. Schimitel, F. G., De Almeida, G. M., Pitol, D. N., Armini, R. S., Tufik, S., & Schenberg, L. C. (2012). Evidence of a suffocation alarm system within the periaqueductal gray matter of the rat. Neuroscience, 200, 59-73. doi: 10.1016/j.neuroscience.2011.10.032
70. Schmidt, N. B., Zvolensky, M. J., & Maner, J. K. (2006). Anxiety sensitivity: Prospective prediction of panic attacks and Axis I pathology. Journal of Psychiatric Research, 40, 691-699. doi: 10.1016/j.jpsychires.2006.07.009
71. Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Wittchen, H.-U. (2014). Stratified medicine for mental disorders. European Neuropsychpharmacology, 24, 5-50. doi: 10.1016/j.euroneuro.2013.09.010
72. Straube, B., Reif, A., Richter, J., Lueken, U., Weber, H., Arolt, V., ... & Kircher, T. (2014). The functional-1019C/G HTR1A polymorphism and mechanisms of fear. Translational Psychiatry, 4, e490. doi: 10.1038/tp.2014.130
73. Taylor, S., & Rachman, S. (1994). Klein's suffocation theory of panic. Archives of General Psychiatry, 51, 505-506. doi: 10.1001/archpsyc.1994.03950060069011
74. Weber, H., Richter, J., Straube, B., Lueken, U., Domschke, K., Schartner, C., ... & Reif, A. (2015). Allelic variation in CRHR1 predisposes to panic disorder by biasing towards fear. Molecular Psychiatry advance online publication. doi: 10.1038/mp.2015.125
75. Westphal, C. (1871). Die Agoraphobie: Eine neuropathische Erscheinung (The agoraphobia: A neuropathic phenomenon). Archiv fuer Psychiatrie und Nervenkrankheiten, 3, 13-171.
76. Wittchen, H.-U., Gloster, A. T., Beesdo-Baum, K., Fava, G. A., & Craske, M. G. (2010). Agoraphobia: A review of the diagnostic classificatory position and criteria. Depression and Anxiety, 27, 113-133. doi: 10.1002/da.20646
77. Wittchen, H.-U., Knappe, S., Andersson, G., Araya, R., Rivera, R. M. B., Barkham, M., ... & Schumann, G. (2014). The need for a behavioural science focus in research on mental health and mental disorders. International Journal of Methods in Psychiatric Research, 23, 28-40. doi: 10.1002/mpr.1409
78. World Health Organization. (1992). The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines. Geneva, Switzerland: Author.