MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 3, 2016, Pages 495-505

  Zhou, Yuhong ^a   Deng, Lin ^a   Zhao, Dandan ^a   Chen, Lanlan ^a   Yao, Zhen ^a   Guo, Xiaowei ^a   Liu, Xue ^a   Lv, Lifang ^a   Leng, Bing ^a   Xu, Wei ^b   Qiao, Guofen ^a   Shan, Hongli ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apelin 13; Cardiac fibrosis; MiR 503

Indexed keywords

ANGIOTENSIN II; APELIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; MICRORNA; MICRORNA 503; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ADIPOCYTOKINE; APLN PROTEIN, MOUSE; MIRN503 MICRORNA, MOUSE; SIGNAL PEPTIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HEART FIBROBLAST; HEART HYPERTROPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; LUCIFERASE ASSAY; M MODE ECHOCARDIOGRAPHY; MALE; MOUSE; MTT ASSAY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; 3' UNTRANSLATED REGION; ANIMAL; BINDING SITE; C57BL MOUSE; CARDIAC MUSCLE; CELL CULTURE; CHEMICALLY INDUCED; FIBROBLAST; FIBROSIS; GENE EXPRESSION; GENETICS; HEART DISEASE; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; ADIPOKINES; ANGIOTENSIN II; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; FIBROSIS; GENE EXPRESSION; HEART DISEASES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE, INBRED C57BL; MICRORNAS; MYOCARDIUM; RNA INTERFERENCE;

EID: 84958611444     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12754     Document Type: Article

References (33)

1. Brown RD, Ambler SK, Mitchell MD, et al. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol. 2005; 45: 657-87.
2. Jugdutt BI. Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr Drug Targets Cardiovasc Haematol Disord. 2003; 3: 1-30.
3. Porter KE, Turner NA. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther. 2009; 123: 255-78.
4. Yang B, Lin H, Xiao J, et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med. 2007; 13: 486-91.
5. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007; 13: 613-8.
6. Sayed D, Hong C, Chen IY, et al. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res. 2007; 100: 416-24.
7. van Rooij E, Sutherland LB, Liu N, et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA. 2006; 103: 8255-60.
8. Ren XP, Wu J, Wang X, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation. 2009; 119: 2357-66.
9. Abonnenc M, Nabeebaccus AA, Mayr U, et al. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013; 113: 1138-47.
10. Dai Y, Dai D, Mehta JL. MicroRNA-29, a mysterious regulator in myocardial fibrosis and circulating miR-29a as a biomarker. J Am Coll Cardiol. 2014; 64: 2181.
11. Roy S, Khanna S, Hussain SR, et al. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res. 2009; 82: 21-9.
12. Pan Z, Sun X, Shan H, et al. MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation. 2012; 126: 840-50.
13. Dai Y, Khaidakov M, Wang X, et al. MicroRNAs involved in the regulation of postischemic cardiac fibrosis. Hypertension. 2013; 61: 751-6.
14. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998; 251: 471-6.
15. Pchejetski D, Foussal C, Alfarano C, et al. Apelin-13 prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. Eur Heart J. 2012; 33: 2360-9.
16. Li L, Zeng H, Chen JX. Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction. Am J Physiol Heart Circ Physiol. 2012; 303: H605-18.
17. Zhao JJ, Yang J, Lin J. Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis. Childs Nerv Syst. 2009; 25: 13-20.
18. Caporali A, Emanueli C. MicroRNA-503 and the extended microRNA-16 family in angiogenesis. Trends Cardiovasc Med. 2011; 21: 162-6.
19. Corbetta S, Vaira V, Guarnieri V. Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. Endocr Relat Cancer. 2010; 17: 135-46.
20. Tömböl Z, Szabó PM, Molnár V. Integrative molecular bioinformatics study of human adrenocortical tumors: MicroRNA, tissue-specific target prediction, and pathway analysis. Endocr Relat Cancer. 2009; 16: 895-906.
21. Wang XH, Qian RZ, Zhang W. MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol. 2009; 36: 181-8.
22. Caporali A, Meloni M, Völlenkle C, et al. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation. 2011; 123: 282-91.
23. Kim J, Kang Y, Kojima Y, et al. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013; 19: 74-82.
24. Peng Y, Liu YM, Li LC, et al. microRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition. Oncol Lett. 2014; 7: 1233-8.
25. Zhang Y, Chen X, Lian H, et al. MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncol Rep. 2014; 31: 1445-52.
26. Xiao F, Zhang W, Chen L, et al. MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med. 2013; 11: 195.
27. Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008; 456: 980-4.
28. Nagano K, Ishida J, Unno M, et al. Apelin elevates blood pressure in ICR mice with L-NAME-induced endothelial dysfunction. Mol Med Rep. 2013; 7: 1371-5.
29. Siddiquee K, Hampton J, Khan S, et al. Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production. J Hypertens. 2011; 29: 724-31.
30. Haydont V, Mathé D, Bourgier C, et al. Induction of CTGF by TGF-beta1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives. Radiother Oncol. 2005; 76: 219-25.
31. Tzortzaki EG, Antoniou KM, Zervou MI, et al. Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis. Respir Med. 2007; 101: 821-9.
32. Frazier K, Williams S, Kothapalli D, et al. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol. 1996; 107: 404-11.
33. Shi-Wen X, Leask A, Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 2008; 19: 133-44.