Pulmonary but not subcutaneous delivery of BCG vaccine confers protection to tuberculosis-susceptible mice by an interleukin 17-dependent mechanism

Journal of Infectious Diseases

Volumn 212, Issue 11, 2015, Pages 831-839

  Aguilo, Nacho ^a,d   Alvarez Arguedas, Samuel ^a,d   Uranga, Santiago ^a,d   Marinova, Dessislava ^a,d   Monzón, Marta ^b   Badiola, Juan ^b   Martin, Carlos ^a,c,d  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

BCG; IgA; IL 17; Mucosal vaccine; Tuberculosis susceptible mice

Indexed keywords

BCG VACCINE; IMMUNOGLOBULIN A; INTERLEUKIN 17; GAMMA INTERFERON; SECRETORY COMPONENT;

ANIMAL; C57BL MOUSE; DBA MOUSE; FEMALE; GENETICS; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MOUSE; MYCOBACTERIUM TUBERCULOSIS; SUBCUTANEOUS DRUG ADMINISTRATION; TUBERCULOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL LOAD; BCG VACCINATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MEGADOSE; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; IN VIVO STUDY; INFECTION PREVENTION; INTRAPULMONARY DRUG ADMINISTRATION; LONG TERM SURVIVAL; LOW DRUG DOSE; LUNG TUBERCULOSIS; MUCOSAL IMMUNITY; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY SYSTEM; TH17 CELL;

ADMINISTRATION, INTRANASAL; ANIMALS; BCG VACCINE; FEMALE; IMMUNOGLOBULIN A; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84958603814     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv503     Document Type: Article

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