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Volumn 7, Issue 2, 2015, Pages 85-96

Nivolumab in NSCLC: Latest evidence and clinical potential

Author keywords

immune checkpoint modulator; nivolumab; non small cell lung cancer; programmed death 1; programmed death 1 ligand

Indexed keywords

AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; AZACITIDINE; BIOLOGICAL MARKER; CARBOPLATIN; CISPLATIN; ERLOTINIB; GEMCITABINE; IPILIMUMAB; NIVOLUMAB; PACLITAXEL; PEMBROLIZUMAB; PEMETREXED; PROGRAMMED DEATH 1 LIGAND 1;

EID: 84924809260     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834014567470     Document Type: Review
Times cited : (194)

References (80)
  • 1
    • 77249095138 scopus 로고    scopus 로고
    • PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell dependent airway hyperreactivity in opposing directions
    • Akbari O. Stock P. Singh A. Lombardi V. Lee W. Freeman G. et al. (2010) PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell dependent airway hyperreactivity in opposing directions. Mucosal Immunol 3: 81–91.
    • (2010) Mucosal Immunol , vol.3 , pp. 81-91
    • Akbari, O.1    Stock, P.2    Singh, A.3    Lombardi, V.4    Lee, W.5    Freeman, G.6
  • 2
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
    • Akbay E. Koyama S. Carretero J. Altabef A. Tchaicha J. Christensen C. et al. (2013) Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov 3: 1355–1363.
    • (2013) Cancer Discov , vol.3 , pp. 1355-1363
    • Akbay, E.1    Koyama, S.2    Carretero, J.3    Altabef, A.4    Tchaicha, J.5    Christensen, C.6
  • 4
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum- based doublet chemotherapy (Pt-DC) in advanced non-small cell lung cancer (NSCLC)
    • Antonia S. Brahmer J. Gettinger S. Chow L. Juergens R. Shepherd F. et al. (2014 a) Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum- based doublet chemotherapy (Pt-DC) in advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 32: 8113.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8113
    • Antonia, S.1    Brahmer, J.2    Gettinger, S.3    Chow, L.4    Juergens, R.5    Shepherd, F.6
  • 5
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results
    • Antonia S. Gettinger S. Chow L. Juergens R. Borghaei H. Shen Y. et al. (2014 b) Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. ASCO Meeting Abstracts 32: 8023.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8023
    • Antonia, S.1    Gettinger, S.2    Chow, L.3    Juergens, R.4    Borghaei, H.5    Shen, Y.6
  • 6
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer
    • Azuma K. Ota K. Kawahara A. Hattori S. Iwama E. Harada T. et al. (2014) Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer. Ann Oncol 25: 1935–1940.
    • (2014) Ann Oncol , vol.25 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Harada, T.6
  • 8
    • 84875936184 scopus 로고    scopus 로고
    • Harnessing the immune system for the treatment of non-small-cell lung cancer
    • Brahmer J. (2013) Harnessing the immune system for the treatment of non-small-cell lung cancer. J Clin Oncol 31: 1021–1028.
    • (2013) J Clin Oncol , vol.31 , pp. 1021-1028
    • Brahmer, J.1
  • 9
    • 84894499071 scopus 로고    scopus 로고
    • Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
    • Brahmer J. (2014) Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Semin Oncol 41: 126–132.
    • (2014) Semin Oncol , vol.41 , pp. 126-132
    • Brahmer, J.1
  • 10
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer J. Drake C. Wollner I. Powderly J. Picus J. Sharfman W. et al. (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28: 3167–3175.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.1    Drake, C.2    Wollner, I.3    Powderly, J.4    Picus, J.5    Sharfman, W.6
  • 12
    • 84912130561 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (Pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis
    • Brahmer J. Horn L. Gandhi L. Spigel D. Antonia S. Rizvi N. et al. (2014) Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (Pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. ASCO Meeting Abstracts 32: 8112.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8112
    • Brahmer, J.1    Horn, L.2    Gandhi, L.3    Spigel, D.4    Antonia, S.5    Rizvi, N.6
  • 13
    • 84892485531 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer
    • Brahmer J. Pardoll D. (2013) Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer. Cancer Immunol Res 1: 85–91.
    • (2013) Cancer Immunol Res , vol.1 , pp. 85-91
    • Brahmer, J.1    Pardoll, D.2
  • 14
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J. Tykodi S. Chow L. Hwu W. Topalian S. Hwu P. et al. (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366: 2455–2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.1    Tykodi, S.2    Chow, L.3    Hwu, W.4    Topalian, S.5    Hwu, P.6
  • 16
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: next-generation immunotherapy–nhibiting programmed death-ligand 1 and programmed death-1
    • Chen D. Irving B. Hodi F. (2012) Molecular pathways: next-generation immunotherapy–nhibiting programmed death-ligand 1 and programmed death-1. Clin Cancer Res 18: 6580–6587.
    • (2012) Clin Cancer Res , vol.18 , pp. 6580-6587
    • Chen, D.1    Irving, B.2    Hodi, F.3
  • 17
    • 84873666114 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
    • Chen Y. Mu C. Huang J. (2012) Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study.Tumori 98: 751–755.
    • (2012) Tumori , vol.98 , pp. 751-755
    • Chen, Y.1    Mu, C.2    Huang, J.3
  • 18
    • 84885633682 scopus 로고    scopus 로고
    • Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients
    • Chen Y. Wang L. Zhu H. Li X. Zhu Y. Yin Y. et al. (2013) Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients. Chin Med Sci J 28: 147–151.
    • (2013) Chin Med Sci J , vol.28 , pp. 147-151
    • Chen, Y.1    Wang, L.2    Zhu, H.3    Li, X.4    Zhu, Y.5    Yin, Y.6
  • 19
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B 16 melanoma tumors
    • Curran M. Montalvo W. Yagita H. Allison J. (2010) PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B 16 melanoma tumors. Proc Natl Acad Sci U S A 107: 4275–4280.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.1    Montalvo, W.2    Yagita, H.3    Allison, J.4
  • 20
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H. Strome S. Salomao D. Tamura H. Hirano F. Flies D. et al. (2002) Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8: 793–800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.2    Salomao, D.3    Tamura, H.4    Hirano, F.5    Flies, D.6
  • 21
    • 36748999428 scopus 로고    scopus 로고
    • Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
    • Downey S. Klapper J. Smith F. Yang J. Sherry R. Royal R. et al. (2007) Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 13: 6681–6688.
    • (2007) Clin Cancer Res , vol.13 , pp. 6681-6688
    • Downey, S.1    Klapper, J.2    Smith, F.3    Yang, J.4    Sherry, R.5    Royal, R.6
  • 22
    • 0018118221 scopus 로고
    • Long-term results in combined-modality treatment of small cell carcinoma of the lung
    • Einhorn L. Bond W. Hornback N. Joe B. (1978) Long-term results in combined-modality treatment of small cell carcinoma of the lung. Semin Oncol 5: 309–313.
    • (1978) Semin Oncol , vol.5 , pp. 309-313
    • Einhorn, L.1    Bond, W.2    Hornback, N.3    Joe, B.4
  • 23
    • 84879477789 scopus 로고    scopus 로고
    • Ipilimumab and its toxicities: a multidisciplinary approach
    • Fecher L. Agarwala S. Hodi F. Weber J. (2013) Ipilimumab and its toxicities: a multidisciplinary approach. Oncologist 18: 733–743.
    • (2013) Oncologist , vol.18 , pp. 733-743
    • Fecher, L.1    Agarwala, S.2    Hodi, F.3    Weber, J.4
  • 24
    • 84875039618 scopus 로고    scopus 로고
    • Combining radiotherapy and cancer immunotherapy: a paradigm shift
    • Formenti S. Demaria S. (2013) Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 105: 256–265.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 256-265
    • Formenti, S.1    Demaria, S.2
  • 25
    • 84881065928 scopus 로고    scopus 로고
    • Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment
    • Freire J. Ajona D. de Biurrun G. Agorreta J. Segura V. Guruceaga E. et al. (2013) Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment. Neoplasia 15: 913–924.
    • (2013) Neoplasia , vol.15 , pp. 913-924
    • Freire, J.1    Ajona, D.2    de Biurrun, G.3    Agorreta, J.4    Segura, V.5    Guruceaga, E.6
  • 27
    • 33749127585 scopus 로고    scopus 로고
    • Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients
    • Gandhi M. Lambley E. Duraiswamy J. Dua U. Smith C. Elliott S. et al. (2006) Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood 108: 2280–2289.
    • (2006) Blood , vol.108 , pp. 2280-2289
    • Gandhi, M.1    Lambley, E.2    Duraiswamy, J.3    Dua, U.4    Smith, C.5    Elliott, S.6
  • 29
    • 84924793481 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1(PD-L1) expression in a pooled analysis of patients with advanced NSCLC
    • LBA43.
    • Garon E. Gandhi L. Rizvi N. Hui R. Balmanoukian A. Patnaik A. et al. (2014 a) Antitumor activity of pembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1(PD-L1) expression in a pooled analysis of patients with advanced NSCLC. ESMO Meeting Abstracts LBA43.
    • (2014) ESMO Meeting Abstracts
    • Garon, E.1    Gandhi, L.2    Rizvi, N.3    Hui, R.4    Balmanoukian, A.5    Patnaik, A.6
  • 30
    • 84907614647 scopus 로고    scopus 로고
    • Safety and clinical activity of MK-3475 in previously treated patients (Pts) with non-small cell lung cancer (NSCLC)
    • Garon E. Leighl N. Rizvi N. Blumenschein G. Balmanoukian A. Eder J. et al. (2014 b) Safety and clinical activity of MK-3475 in previously treated patients (Pts) with non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 32: 8020.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8020
    • Garon, E.1    Leighl, N.2    Rizvi, N.3    Blumenschein, G.4    Balmanoukian, A.5    Eder, J.6
  • 31
    • 84907651086 scopus 로고    scopus 로고
    • First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status
    • Gettinger S. Shepherd F. Antonia S. Brahmer J. Chow L. Juergens R. et al. (2014) First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status. ASCO Meeting Abstracts 32: 8024.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8024
    • Gettinger, S.1    Shepherd, F.2    Antonia, S.3    Brahmer, J.4    Chow, L.5    Juergens, R.6
  • 32
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F. Menard C. Puig P. Ladoire S. Roux S. Martin F. et al. (2007) Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 56: 641–648.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 33
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • Goel S. Duda D. Xu L. Munn L. Boucher Y. Fukumura D. et al. (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91: 1071–1121.
    • (2011) Physiol Rev , vol.91 , pp. 1071-1121
    • Goel, S.1    Duda, D.2    Xu, L.3    Munn, L.4    Boucher, Y.5    Fukumura, D.6
  • 34
    • 38449109340 scopus 로고    scopus 로고
    • Docetaxel-induced interstitial pneumonitis following non-small-cell lung cancer treatment
    • Grande C. Villanueva M. Huidobro G. Casal J. (2007) Docetaxel-induced interstitial pneumonitis following non-small-cell lung cancer treatment. Clin Transl Oncol 9: 578–581.
    • (2007) Clin Transl Oncol , vol.9 , pp. 578-581
    • Grande, C.1    Villanueva, M.2    Huidobro, G.3    Casal, J.4
  • 35
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O. Robert C. Daud A. Hodi F. Hwu W. Kefford R. et al. (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369: 134–144.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.4    Hwu, W.5    Kefford, R.6
  • 36
    • 84655165056 scopus 로고    scopus 로고
    • Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy
    • Harmankaya K. Erasim C. Koelblinger C. Ibrahim R. Hoos A. Pehamberger H. et al. (2011) Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy. Med Oncol 28: 1140–1144.
    • (2011) Med Oncol , vol.28 , pp. 1140-1144
    • Harmankaya, K.1    Erasim, C.2    Koelblinger, C.3    Ibrahim, R.4    Hoos, A.5    Pehamberger, H.6
  • 37
    • 84904855312 scopus 로고    scopus 로고
    • Immunologic and clinical effects of targeting PD-1 in lung cancer
    • Harvey R. (2014) Immunologic and clinical effects of targeting PD-1 in lung cancer. Clin Pharmacol Ther 96: 214–223.
    • (2014) Clin Pharmacol Ther , vol.96 , pp. 214-223
    • Harvey, R.1
  • 38
    • 84904856533 scopus 로고    scopus 로고
    • An analysis of the relationship of clinical activity to baseline EGFR status, PD-L1 expression and prior treatment history in patients with non-small cell lung cancer (NSCLC) following PD-L1 blockade with MPDL3280A (anti-PD-L1)
    • 15th World Conference on Lung Cancer Sydney, Australia
    • Horn L. Herbst R. Spigel D. Gettinger S. Gordon M. Hollebecque A. et al. (2013) An analysis of the relationship of clinical activity to baseline EGFR status, PD-L1 expression and prior treatment history in patients with non-small cell lung cancer (NSCLC) following PD-L1 blockade with MPDL3280A (anti-PD-L1). In: 15th World Conference on Lung Cancer, Sydney, Australia.
    • (2013)
    • Horn, L.1    Herbst, R.2    Spigel, D.3    Gettinger, S.4    Gordon, M.5    Hollebecque, A.6
  • 39
    • 79958043675 scopus 로고    scopus 로고
    • Bethesda, MD: National Cancer Institute Based on November 2013 SEER data submission, posted to the SEER web site, April 2014 (accessed 3 December 2014).
    • Howlader N. Noone A. Krapcho M. Garshell J. Miller D. Altekruse S. et al. (2014) SEER Cancer Statistics Review, 1975–2011. Bethesda, MD: National Cancer Institute. Based on November 2013 SEER data submission, posted to the SEER web site, April 2014 http://seer.cancer.gov/csr/1975_2011/ (accessed 3 December 2014).
    • (2014) SEER Cancer Statistics Review, 1975–2011
    • Howlader, N.1    Noone, A.2    Krapcho, M.3    Garshell, J.4    Miller, D.5    Altekruse, S.6
  • 41
    • 84877870613 scopus 로고    scopus 로고
    • Vascular normalization as an emerging strategy to enhance cancer immunotherapy
    • Huang Y. Goel S. Duda D. Fukumura D. Jain R. (2013) Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res 73: 2943–2948.
    • (2013) Cancer Res , vol.73 , pp. 2943-2948
    • Huang, Y.1    Goel, S.2    Duda, D.3    Fukumura, D.4    Jain, R.5
  • 42
    • 0026653868 scopus 로고
    • Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer
    • Jansen R. Slingerland R. Goey S. Franks C. Bolhuis R. Stoter G. (1992) Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer. J Immunother 12: 70–73.
    • (1992) J Immunother , vol.12 , pp. 70-73
    • Jansen, R.1    Slingerland, R.2    Goey, S.3    Franks, C.4    Bolhuis, R.5    Stoter, G.6
  • 44
  • 45
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi K. Woan K. Gilvary D. Sahakian E. Wei S. Djeu J. (2010) A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 16: 4583–4594.
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.1    Woan, K.2    Gilvary, D.3    Sahakian, E.4    Wei, S.5    Djeu, J.6
  • 46
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi J. Yamazaki K. Azuma M. Kinoshita I. Dosaka-Akita H. Nishimura M. (2004) B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 10: 5094–5100.
    • (2004) Clin Cancer Res , vol.10 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3    Kinoshita, I.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 47
    • 20144388909 scopus 로고    scopus 로고
    • Analysis of the response and toxicity to gefitinib of non-small cell lung cancer
    • Konishi J. Yamazaki K. Kinoshita I. Isobe H. Ogura S. Sekine S. et al. (2005) Analysis of the response and toxicity to gefitinib of non-small cell lung cancer. Anticancer Res 25: 435–441.
    • (2005) Anticancer Res , vol.25 , pp. 435-441
    • Konishi, J.1    Yamazaki, K.2    Kinoshita, I.3    Isobe, H.4    Ogura, S.5    Sekine, S.6
  • 49
    • 84867888741 scopus 로고    scopus 로고
    • Targeting ROS 1 with anaplastic lymphoma kinase (ALK) inhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small cell lung cancer
    • Leow P. Soo R. Soong R. Ou S. (2012) Targeting ROS 1 with anaplastic lymphoma kinase (ALK) inhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small cell lung cancer. J Thorac Oncol 7: 1625–1630.
    • (2012) J Thorac Oncol , vol.7 , pp. 1625-1630
    • Leow, P.1    Soo, R.2    Soong, R.3    Ou, S.4
  • 50
    • 74249120625 scopus 로고    scopus 로고
    • Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    • Liu W. Fowler D. Smith P. Dalgleish A. (2010) Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses. Br J Cancer 102: 115–123.
    • (2010) Br J Cancer , vol.102 , pp. 115-123
    • Liu, W.1    Fowler, D.2    Smith, P.3    Dalgleish, A.4
  • 52
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIb / IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • Lynch T. Bondarenko I. Luft A. Serwatowski P. Barlesi F. Chacko R. et al. (2012) Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIb / IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 30: 2046–2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6
  • 53
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer
    • may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu C. Huang J. Chen Y. Chen C. Zhang X. (2011) High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 28: 682–688.
    • (2011) Med Oncol , vol.28 , pp. 682-688
    • Mu, C.1    Huang, J.2    Chen, Y.3    Chen, C.4    Zhang, X.5
  • 54
    • 84993686594 scopus 로고    scopus 로고
    • Human Anti-human PD-1 Monoclonal Antibody “OPDIVO® Intravenous Infusion 20 mg/100 mg” Receives Manufacturing and Marketing Approval in Japan for the Treatment of Unresectable Melanoma
    • ONO Pharmaceutical Available at (accessed 6 August 2014)
    • ONO Pharmaceutical (2014) Human Anti-human PD-1 Monoclonal Antibody “OPDIVO® Intravenous Infusion 20 mg/100 mg” Receives Manufacturing and Marketing Approval in Japan for the Treatment of Unresectable Melanoma. Available at: http://www.ono.co.jp/eng/news/pdf/sm_cn140704.pdf (accessed 6 August 2014)
    • (2014)
  • 55
    • 84867696992 scopus 로고    scopus 로고
    • When progressive disease does not mean treatment failure: reconsidering the criteria for progression
    • Oxnard G. Morris M. Hodi F. Baker L. Kris M. Venook A. et al. (2012) When progressive disease does not mean treatment failure: reconsidering the criteria for progression. J Natl Cancer Inst 104: 1534–1541.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1534-1541
    • Oxnard, G.1    Morris, M.2    Hodi, F.3    Baker, L.4    Kris, M.5    Venook, A.6
  • 56
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll D. (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12: 252–264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.1
  • 57
    • 84993742427 scopus 로고    scopus 로고
    • Phase II study of nivolumab (Anti-PD-1, BMS-936558, ONO-4538) in patients with advanced, refractory squamous non-small cell lung cancer
    • Multidisciplinary Symposium in Thoracic Oncology abstract LB2.
    • Ramalingam S. Mazieres J. Planchard D., Stinchcombe, T., Dy, G., Antonia, S. et al. (2014) Phase II study of nivolumab (Anti-PD-1, BMS-936558, ONO-4538) in patients with advanced, refractory squamous non-small cell lung cancer. In: Multidisciplinary Symposium in Thoracic Oncology, abstract LB2.
    • (2014)
    • Ramalingam, S.1    Mazieres, J.2    Planchard, D.S.T.D.G.A.S.3
  • 58
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (Pts) with epidermal growth factor receptor mutant (EGFR Mt) advanced NSCLC
    • Rizvi N. Chow L. Borghaei H. Shen Y. Harbison C. Alaparthy S. et al. (2014) Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (Pts) with epidermal growth factor receptor mutant (EGFR Mt) advanced NSCLC. ASCO Meeting Abstracts 32: 8022.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 8022
    • Rizvi, N.1    Chow, L.2    Borghaei, H.3    Shen, Y.4    Harbison, C.5    Alaparthy, S.6
  • 59
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7f9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagne F. Andre P. Spee P. Zahn S. Anfossi N. Gauthier L. et al. (2009) Preclinical characterization of 1-7f9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 114: 2667–2677.
    • (2009) Blood , vol.114 , pp. 2667-2677
    • Romagne, F.1    Andre, P.2    Spee, P.3    Zahn, S.4    Anfossi, N.5    Gauthier, L.6
  • 61
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L. Capanni M. Urbani E. Perruccio K. Shlomchik W. Tosti A. et al. (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295: 2097–2100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3    Perruccio, K.4    Shlomchik, W.5    Tosti, A.6
  • 62
    • 0028926389 scopus 로고
    • Concomitant administration of interleukin-2 plus tumor necrosis factor in advanced non-small cell lung cancer
    • Schiller J. Morgan-Ihrig C. Levitt M. (1995) Concomitant administration of interleukin-2 plus tumor necrosis factor in advanced non-small cell lung cancer. Am J Clin Oncol 18: 47–51.
    • (1995) Am J Clin Oncol , vol.18 , pp. 47-51
    • Schiller, J.1    Morgan-Ihrig, C.2    Levitt, M.3
  • 63
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber R. Old L. Smyth M. (2011) Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331: 1565–1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.1    Old, L.2    Smyth, M.3
  • 64
    • 84895798759 scopus 로고    scopus 로고
    • Clinical activity, safety and biomarkers of PD-L1 blockade in non-small cell lung cancer (NSCLC): additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PD-L1)
    • Amsterdam, The Netherlands abstract 3408.
    • Soria J. Cruz C. Bahleda R. Delord J. Horn L. Herbst R. et al. (2013) Clinical activity, safety and biomarkers of PD-L1 blockade in non-small cell lung cancer (NSCLC): additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PD-L1). In: European Cancer Congress, Amsterdam, The Netherlands, abstract 3408.
    • (2013) European Cancer Congress
    • Soria, J.1    Cruz, C.2    Bahleda, R.3    Delord, J.4    Horn, L.5    Herbst, R.6
  • 65
    • 38449121249 scopus 로고    scopus 로고
    • Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth
    • Stewart T. Abrams S. (2007) Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth. J Immunol 179: 2851–2859.
    • (2007) J Immunol , vol.179 , pp. 2851-2859
    • Stewart, T.1    Abrams, S.2
  • 66
    • 74249123333 scopus 로고    scopus 로고
    • ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer
    • Solomon B. Varella-Garcia M. Camidge D. (2009) ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer. J Thorac Oncol 4: 1450–1454.
    • (2009) J Thorac Oncol , vol.4 , pp. 1450-1454
    • Solomon, B.1    Varella-Garcia, M.2    Camidge, D.3
  • 68
    • 84904112296 scopus 로고    scopus 로고
    • Immunotherapy in the treatment of non-small cell lung cancer
    • Sundar R. Soong R. Cho B. Brahmer J. Soo R. (2014) Immunotherapy in the treatment of non-small cell lung cancer. Lung Cancer 85: 101–109.
    • (2014) Lung Cancer , vol.85 , pp. 101-109
    • Sundar, R.1    Soong, R.2    Cho, B.3    Brahmer, J.4    Soo, R.5
  • 69
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E. Kapoor V. Jassar A. Kaiser L. Albelda S. (2005) Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res 11: 6713–6721.
    • (2005) Clin Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.3    Kaiser, L.4    Albelda, S.5
  • 70
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube J. Anders R. Young G. Xu H. Sharma R. McMiller T. et al. (2012) Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 4: 127–137.
    • (2012) Sci Transl Med , vol.4 , pp. 127-137
    • Taube, J.1    Anders, R.2    Young, G.3    Xu, H.4    Sharma, R.5    McMiller, T.6
  • 72
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng S. Otsuji M. Gorski K. Huang X. Slansky J. Pai S. et al. (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med 193: 839–846.
    • (2001) J Exp Med , vol.193 , pp. 839-846
    • Tseng, S.1    Otsuji, M.2    Gorski, K.3    Huang, X.4    Slansky, J.5    Pai, S.6
  • 73
    • 0030760194 scopus 로고    scopus 로고
    • Tumor antigens recognized by T lymphocytes
    • van Den Eynde B. Boon T. (1997) Tumor antigens recognized by T lymphocytes. Int J Clin Lab Res 27: 81–86.
    • (1997) Int J Clin Lab Res , vol.27 , pp. 81-86
    • van Den Eynde, B.1    Boon, T.2
  • 75
    • 84890130945 scopus 로고    scopus 로고
    • Alterations of immune response of non-small cell lung cancer with azacytidine
    • Wrangle J. Wang W. Koch A. Easwaran H. Mohammad H. Vendetti F. et al. (2013) Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget 4: 2067–2079.
    • (2013) Oncotarget , vol.4 , pp. 2067-2079
    • Wrangle, J.1    Wang, W.2    Koch, A.3    Easwaran, H.4    Mohammad, H.5    Vendetti, F.6
  • 76
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
    • Wolchok J. Hoos A. O'Day S. Weber J. Hamid O. Lebbe C. et al. (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15: 7412–7420.
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.1    Hoos, A.2    O'Day, S.3    Weber, J.4    Hamid, O.5    Lebbe, C.6
  • 78
    • 84897404380 scopus 로고    scopus 로고
    • Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
    • Yang C. Lin M. Chang Y. Wu C. Yang P. (2014) Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer 50: 1361–1369.
    • (2014) Eur J Cancer , vol.50 , pp. 1361-1369
    • Yang, C.1    Lin, M.2    Chang, Y.3    Wu, C.4    Yang, P.5
  • 79
    • 54049093133 scopus 로고    scopus 로고
    • Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy
    • Zhang L. Dermawan K. Jin M. Liu R. Zheng H. Xu L. et al. (2008) Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy. Clin Immunol 129: 219–229.
    • (2008) Clin Immunol , vol.129 , pp. 219-229
    • Zhang, L.1    Dermawan, K.2    Jin, M.3    Liu, R.4    Zheng, H.5    Xu, L.6
  • 80
    • 84898843963 scopus 로고    scopus 로고
    • Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
    • Zhang Y. Wang L. Li Y. Pan Y. Wang R. Hu H. et al. (2014) Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma. Onco Targets Ther 7: 567–573.
    • (2014) Onco Targets Ther , vol.7 , pp. 567-573
    • Zhang, Y.1    Wang, L.2    Li, Y.3    Pan, Y.4    Wang, R.5    Hu, H.6


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