Evaluating mitochondrial autophagy in the mouse heart

Journal of Molecular and Cellular Cardiology

Volumn 92, Issue , 2016, Pages 134-139

  Shirakabe, Akihiro ^a   Fritzky, Luke ^a   Saito, Toshiro ^a   Zhai, Peiyong ^a   Miyamoto, Shigeki ^b   Gustafsson, Åsa B ^c   Kitsis, Richard N ^d   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Keima; Lamp1; Mitophagy

Indexed keywords

CYTOCHROME B; FLUORESCENT DYE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITO KEIMA; MITOCHONDRIAL DNA; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ADULT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; HEART MITOCHONDRION; LYSOSOME; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; AUTOPHAGY; CARDIAC MUSCLE CELL; DEPENDOPARVOVIRUS; GENETICS; METABOLISM; MITOCHONDRION; PH; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGY; DEPENDOVIRUS; DNA, MITOCHONDRIAL; HYDROGEN-ION CONCENTRATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMES; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MYOCYTES, CARDIAC;

EID: 84958550863     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.02.007     Document Type: Article

References (11)

1. Gatica D., Chiong M., Lavandero S., Klionsky D.J. Molecular mechanisms of autophagy in the cardiovascular system. Circ. Res. 2015, 116:456-467.
2. Saito T., Sadoshima J. The molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ. Res. 2015, 116:1477-1490.
3. Youle R.J., Narendra D.P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 2011, 12:9-14.
4. Ikeda Y., Shirakabe A., Maejima Y., Zhai P., Sciarretta S., Toli J., et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ. Res. 2015, 116:264-278.
5. Okonko D.O., Shah A.M. Heart failure: mitochondrial dysfunction and oxidative stress in CHF. Nat. Rev. Cardiol. 2015, 12:6-8.
6. Scott I., Webster B.R., Chan C.K., Okonkwo J.U., Han K., Sack M.N. GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. J. Biol. Chem. 2014, 289:2864-2872.
7. Katayama H., Kogure T., Mizushima N., Yoshimori T., Miyawaki A. A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem. Biol. 2011, 18:1042-1052.
8. Doroudgar S., Volkers M., Thuerauf D.J., Khan M., Mohsin S., Respress J.L., et al. Hrd1 and ER-associated protein degradation, ERAD, are critical elements of the adaptive ER stress response in cardiac myocytes. Circ. Res. 2015, 117:536-546.
9. Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., et al. Distinct roles of autophagy in the heart during ischemia and reperfusion. Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007, 100:914-922.
10. Johnson S., Rabinovitch P. Ex vivo imaging of excised tissue using vital dyes and confocal microscopy. Current protocols in cytometry/editorial board, J Paul Robinson, managing editor [et al] 2012, Chapter 9:Unit 9 39.
11. Sun N., Yun J., Liu J., Malide D., Liu C., Rovira, et al. Measuring in vivo mitophagic flux. Mol. Cell 2016, (in press).