Does an Obesity Paradox Really Exist after Cardiovascular Intervention?: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies

Medicine (United States)

Volumn 94, Issue 44, 2015, Pages e1910-

  Bundhun, Pravesh Kumar ^a   Li, Nuo ^a   Chen, Meng Hua ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; ANTHROPOMETRIC PARAMETERS; BODY MASS; BODY WEIGHT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; DIABETES MELLITUS; DYSLIPIDEMIA; EMBASE; FOLLOW UP; HOSPITAL PATIENT; HUMAN; HYPERTENSION; LONG TERM CARE; MEDLINE; META ANALYSIS; OBESITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; RISK FACTOR; SMOKING; SYSTEMATIC REVIEW; TREATMENT DURATION; ADVERSE EFFECTS; CARDIOVASCULAR DISEASES; COMPLICATION;

BODY MASS INDEX; CARDIOVASCULAR DISEASES; HUMANS; OBESITY; OBSERVATIONAL STUDIES AS TOPIC; PERCUTANEOUS CORONARY INTERVENTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS;

EID: 84958291983     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000001910     Document Type: Review

References (48)

1. Berghofer A, Pischon T, Reinhold T, et al. Obesity prevalence from a European perspective: a systematic review. BMC Public Health. 2008;8:200.
2. Ogden CL, Yanovski SZ, Carroll MD, et al. The epidemiology of obesity. Gastroenterology. 2007;132:2087-2102.
3. Wilson PW, D'Agostino RB, Sullivan L, et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Internal Med. 2002;162:1867-1872.
4. Flegal KM, Graubard BI, Williamson DF, et al. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007;298:2028-2037.
5. Flegal KM, Graubard BI, Williamson DF, et al. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293:1861-1867.
6. Powell BD, Lennon RJ, Lerman A, et al. Association of body mass index with outcome after percutaneous coronary intervention. Am J Cardiol. 2003;91:472-476.
7. Lancefield T, Clark DJ, Andrianopoulos N, et al. Is there an obesity paradox after percutaneous coronary intervention in the contemporary era? An analysis from a multicenter Australian registry. JACC Cardiovasc Interv. 2010;3:660-668.
8. Oreopoulos A, Padwal R, Norris CM, et al. Effect of obesity on short-and long-term mortality postcoronary revascularization: a meta-analysis. Obesity. 2008;16:442-450.
9. Akin I, Tolg R, Hochadel M, et al. No evidence of "obesity paradox" after treatment with drug-eluting stents in a routine clinical practice: results from the prospective multicenter German DES.DE (German Drug-Eluting Stent) Registry. JACC Cardiovasc Interv. 2012;5:162-169.
10. National Heart L, and Blood Institute Expert Panel. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. http://www.nhlbi.nih.gov/guidelines/obesity (accessed April 3, 2011).
11. Higgins JPT AD. Cochrane handbook for systematic reviews of interventions: Wiley; 2008.
12. Gurm HS, Whitlow PL, Kip KE. The impact of body mass index on short-and long-term outcomes inpatients undergoing coronary revascularization. J Am College Cardiol. 2002;39:834-840.
13. Gruberg L, Weissman NJ, Waksman R, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol. 2002;39:578-584.
14. Poston WS, Haddock CK, Conard M, et al. Impact of obesity on disease-specific health status after percutaneous coronary intervention in coronary disease patients. J Int Assoc Study Obes. 2004;28:1011-1017.
15. Minutello RM, Chou ET, Hong MK, et al. Impact of body mass index on in-hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry). Am J Cardiol. 2004;93:1229-1232.
16. Gruberg L, Mercado N, Milo S, et al. Impact of body mass index on the outcome of patients with multivessel disease randomized to either coronary artery bypass grafting or stenting in the ARTS trial: the obesity paradox II? Am J Cardiol. 2005;95:439-444.
17. Nikolsky E, Kosinski E, Mishkel GJ, et al. Impact of obesity on revascularization and restenosis rates after bare-metal and drugeluting stent implantation (from the TAXUS-IV trial). Am J Cardiol. 2005;95:709-715.
18. Shubair MM, Prabhakaran P, Pavlova V, et al. The relationship of body mass index to outcomes after percutaneous coronary intervention. J Intervent Cardiol. 2006;19:388-395.
19. Buettner HJ, Mueller C, Gick M, et al. The impact of obesity on mortality in UA/non-ST-segment elevation myocardial infarction. Eur Heart J. 2007;28:1694-1701.
20. Mehta L, Devlin W, McCullough PA, et al. Impact of body mass index on outcomes after percutaneous coronary intervention in patients with acute myocardial infarction. Am J Cardiol. 2007;99:906-910.
21. Kosuge M, Kimura K, Kojima S, et al. Impact of body mass index on in-hospital outcomes after percutaneous coronary intervention for ST segment elevation acute myocardial infarction. Circ J. 2008;72:521-525.
22. Das SR, Alexander KP, Chen AY, et al. Impact of body weight and extreme obesity on the presentation, treatment, and in-hospital outcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry). J Am Coll Cardiol. 2011;58:2642-2650.
23. Wang ZJ, Zhou YJ, Zhao YX, et al. Effect of obesity on repeat revascularization in patients undergoing percutaneous coronary intervention with drug-eluting stents. Obesity. 2012;20:141-146.
24. Kaneko H, Yajima J, Oikawa Y, et al. Obesity paradox in Japanese patients after percutaneous coronary intervention: an observation cohort study. J Cardiol. 2013;62:18-24.
25. Kang WY, Jeong MH, Ahn YK, et al. Obesity paradox in Korean patients undergoing primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. J Cardiol. 2010;55:84-91.
26. Park DW, Kim YH, Yun SC, et al. Association of body mass index with major cardiovascular events and with mortality after percutaneous coronary intervention. Circu Cardiovasc Interv. 2013;6:146-153.
27. Witassek F, Schwenkglenks M, Erne P, et al. Impact of Body Mass Index on mortality in Swiss hospital patients with ST-elevation myocardial infarction: does an obesity paradox exist? Swiss Med Weekly. 2014;144:w13986.
28. Colombo MG, Meisinger C, Amann U, et al. Association of obesity and long-term mortality in patients with acute myocardial infarction with and without diabetes mellitus: results from the MONICA/KORA myocardial infarction registry. Cardiovasc Diabetol. 2015;14:24.
29. Numasawa Y, Kohsaka S, Miyata H, et al. Impact of body mass index on in-hospital complications in patients undergoing percutaneous coronary intervention in a Japanese real-world multicenter registry. PloS One. 2015;10:e0124399.
30. He PY, Yang YJ, Qiao SB, et al. Impact of body mass index on the clinical outcomes after percutaneous coronary intervention in patients >75 years old. Chin Med J. 2015;128:638-643.
31. Grover SA, Kaouache M, Rempel P, et al. Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diab Endocrinol. 2015;3:114-122.
32. Mongraw-Chaffin ML, Peters SA, Huxley RR, et al. The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1.2 million participants. Lancet Diab Endocrinol. 2015;3:437-449.
33. De Schutter A, Lavie CJ, Milani RV. The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesityparadox. Prog Cardiovasc Dis. 2014;56:401-408.
34. Shiraishi J, Kohno Y, Sawada T, et al. Relation of obesity to acute myocardial infarction in Japanese patients. Circul J. 2006;70:1525-1530.
35. Jaber WA, Lennon RJ, Mathew V, et al. Application of evidencebased medical therapy is associated with improved outcomes after percutaneous coronary intervention and is a valid quality indicator. J Am Coll Cardiol. 2005;46:1473-1478.
36. Diercks DB, Roe MT, Mulgund J, et al. The obesity paradox in non-ST-segment elevation acute coronary syndromes: results from the Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with early implementation of the American College of Cardiology/American Heart Association Guidelines Quality Improvement Initiative. Am Heart J. 2006;152:140-148.
37. Steinberg BA, Cannon CP, Hernandez AF, et al. Medical therapies and invasive treatments for coronary artery disease by body mass: the "obesity paradox" in the Get With The Guidelines database. Am J Cardiol. 2007;100:1331-1335.
38. Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195-2207.
39. Corica F, Corsonello A, Buemi M, et al. Platelet magnesium depletion in normotensive and hypertensive obese subjects: the role of salt-regulating hormones and catecholamines. Magnes Res. 1999;12:287-296.
40. Hastie CE, Padmanabhan S, Slack R, et al. Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. Eur Heart J. 2010;31:222-226.
41. Oreopoulos A, McAlister FA, Kalantar-Zadeh K, et al. The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH. Eur Heart J. 2009;30:2584-2592.
42. Hainer V, Aldhoon-Hainerova I. Obesity paradox does exist. Diabetes care. 2013;36(Suppl 2):S276-S281.
43. Sharma A, Vallakati A, Einstein AJ, et al. Relationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: evidence from a meta-analysis. Mayo Clin Proc. 2014;89:1080-1100.
44. Wang ZJ, Zhou YJ, Galper BZ, et al. Association of body mass index with mortality and cardiovascular events for patients with coronary arterydisease: a systematic review and meta-analysis. Heart. 2015pii: heartjnl 2014-307119.
45. Lavie CJ, De Schutter A, Milani RV. Body composition and the obesity paradox in coronary heart disease: can heavier really be healthier? Heart. 2015pii: heartjnl-2015 307966.
46. Lavie CJ, McAuley PA, Church TS, et al. Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. J Am Coll Cardiol. 2014;63:1345-1354.
47. Wang ZJ, Zhou YJ, Liu YY, et al. Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents. Heart. 2009;95:1587-1592.
48. Li Y, Wu C, Sun Y, et al. Obesity paradox: clinical benefits not observed in obese patients with ST-segment elevation myocardial infarction: a multicenter, prospective, cohort study of the northern region of China. Int J Cardiol. 2013;168:2949-2950.