No evidence of "obesity Paradox" after treatment with drug-eluting stents in a routine clinical practice: Results from the prospective Multicenter German DES.DE (German Drug-Eluting Stent) registry

JACC: Cardiovascular Interventions

Volumn 5, Issue 2, 2012, Pages 162-169

  Akin, Ibrahim ^a   Tlg, Ralph ^b   Hochadel, Matthias ^c   Bergmann, Martin W ^d   Khattab, Ahmed A ^e   Schneider, Steffen ^c   Senges, Jochen ^c   Kuck, Karl Heinz ^d   Richardt, Gert ^b   Nienaber, Christoph A ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^b Heart Center Bad Segeberg   (Germany)

^c Heart Center Ludwigshafen   (Germany)

^d Asklepios Hospital   (Germany)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

drug eluting stent(s); MACCE; mortality; obesity paradox; TVR

Indexed keywords

PACLITAXEL; RAPAMYCIN;

ADULT; AGED; ARTICLE; BARE METAL STENT; BODY MASS; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CEREBROVASCULAR DISEASE; CORRELATION ANALYSIS; DRUG ELUTING STENT; FEMALE; FOLLOW UP; GERMANY; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; IMPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBESITY; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; REGISTER; RISK FACTOR; STROKE; TARGET VESSEL REVASCULARIZATION;

AGED; ANGIOPLASTY, BALLOON, CORONARY; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BODY MASS INDEX; CORONARY ARTERY DISEASE; DRUG-ELUTING STENTS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; OBESITY; PACLITAXEL; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REGISTRIES; RISK FACTORS; SIROLIMUS; STATISTICS AS TOPIC;

EID: 84857604732     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2011.09.021     Document Type: Article

References (31)

1. K.M. Flegal, M.D. Carroll, C.L. Ogden, L.R. Curtin Prevalence and trends in obesity among US adults, 19992008 JAMA 303 2010 235 241
2. E. Calle, M.J. Thun, J.M. Petrelli, C. Rodriguez, C.W. Health Jr Body mass index and mortality in a prospective cohort of U.S. adults N Engl J Med 341 1999 1097 1105 (Pubitemid 29466221)
3. B.D. Powell, R.J. Lennon, A. Lerman et al. Association of body mass index with outcome after percutaneous coronary intervention Am J Cardiol 91 2003 472 476 (Pubitemid 36183574)
4. S.G. Ellis, J. Elliott, M. Horrigan, R.E. Raymond, G. Howell Low-normal or excessive body mass index: newly identified and powerful risk factors for death and other complications with percutaneous coronary intervention Am J Cardiol 78 1996 642 646 (Pubitemid 126658617)
5. L. Gruberg, N.J. Weissman, R. Waksman et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 39 2002 578 584 (Pubitemid 34158151)
6. H.S. Gurm, D.M. Brennan, J. Booth, J.E. Tcheng, A.M. Lincoff, E.J. Topol Impact of body mass index on outcome after percutaneous coronary intervention (the obesity paradox) Am J Cardiol 90 2002 42 45 (Pubitemid 34671201)
7. R.M. Minutello, E.T. Chou, M.K. Hong et al. Impact of body mass index on in-hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry) Am J Cardiol 93 2004 1229 1232 (Pubitemid 38595675)
8. C.A. Nienaber, I. Akin, S. Schneider et al. Clinical outcome after sirolimus-eluting, paclitaxel-eluting, and bare-metal stents (from the first phase of the prospective muticenter German DES.DE registry) Am J Cardiol 104 2009 1362 1369
9. S. Silber, P. Albertsson, F.F. Avils Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology Guidelines for percutaneous coronary interventions Eur Heart J 26 2005 804 847 (Pubitemid 40547082)
10. S.B. King 3rd, S.C. Smith Jr., J.W. Hirshfeld Jr. 2007 writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention, writing on behalf of the 2005 Writing Committee 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 51 2008 172 209
11. World Health Organization Obesity: Preventing and Managing the Global Epidemic Report of a WHO Consultation on Obesity, June 35, 1997. WHO Technical Series No. 894 2000 World Health Organization Geneva, Switzerland
12. National Institutes of Health Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adultsthe evidence report Obes Res 6 Suppl 1998 51S 209S
13. D.E. Cutlip, S. Windecker, R. Mehran et al. Academic Research Consortium Clinical end points in coronary stent trials: a case for standardized definitions Circulation 115 2007 2344 2351 (Pubitemid 46685903)
14. The GUSTO Investigators An interventional randomized trial comparing four thrombolytic strategies for acute myocardial infarction N Engl J Med 329 1993 673 682
15. R.H. Eckel Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association Circulation 96 1997 3248 3250 (Pubitemid 27500134)
16. F.X. Pi-Sunyer The obesity epidemic: pathophysiology and consequences of obesity Obes Res 10 Suppl 2 2002 97 104
17. R.M. Califf, K.S. Pieper, K.L. Lee et al. Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial Circulation 101 2000 2231 2238 (Pubitemid 30317123)
18. G.C. Fonarow, P. Srikanthan, M.R. Costanzo, G.B. Cintron, M. Lopatin ADHERE Scientific Advisory Committee and Investigators An obesity paradox in acute heart failure: analysis of body mass index and inhospital mortality for 108,927 patients in the acute decompensated heart failure national registry Am Heart J 153 2007 74 81 (Pubitemid 44880872)
19. A. Romero-Corral, V.M. Montori, V.K. Somers et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies Lancet 368 2006 666 678 (Pubitemid 44223694)
20. C.E. Hastie, S. Padmanabhan, R. Slack et al. Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention Eur Heart J 31 2010 222 226
21. E. Nikolsky, E. Kosinski, G.J. Mishkel et al. Impact of obesity on revascularization and restenosis rates after bare-metal and drug-eluting stent implantation (from the TAXUS-IV trial) Am J Cardiol 95 2005 709 715 (Pubitemid 40332647)
22. A.A. Khattab, J. Daemen, G. Richardt et al. Impact of body mass index on the one-year clinical outcome of patients undergoing multivessel revascularization with sirolimus-eluting stents (from the arterial revascularization therapies Study Part II) Am J Cardiol 101 2008 1550 1559
23. D.R. Holmes Jr, H.D. White, K.S. Pieper, S.G. Ellis, R.M. Califf, E.J. Topol Effect of age on outcome with primary angioplasty versus thrombolysis J Am Coll Cardiol 33 1999 412 419 (Pubitemid 29234203)
24. A. Halkin, M. Singh, E. Nikolsky et al. Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction The CADILLAC risk score J Am Coll Cardiol 45 2005 1397 1405 (Pubitemid 40615609)
25. J.E. Manson, W.C. Willett, M.J. Stampfer et al. Body weight and mortality among women N Engl J Med 333 1995 677 685
26. T. Harris, E.F. Cook, R. Garrison, M. Higgins, W. Kannel, L. Goldman Body mass index and mortality among nonsmoking older persons The Framingham Heart Study JAMA 259 1988 1520 1524 (Pubitemid 18062071)
27. I.M. Lee, J.E. Manson, C.H. Hennekens, R.S. Paffenbarger Jr Body weight and mortality A 27-year follow-up of middle-aged men JAMA 270 1993 2823 2828 (Pubitemid 23361645)
28. K.F. Adams, A. Schatzkin, T.B. Harris et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old N Engl J Med 355 2006 763 778 (Pubitemid 44285582)
29. A. Tremblay, V. Bandi Impact of body mass index on outcomes following critical care Chest 123 2003 1202 1207 (Pubitemid 36444379)
30. D.J. Angiolillo, A. Fernndez-Ortiz, E. Bernardo et al. Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted? J Invasive Cardiol 16 2004 169 174 (Pubitemid 38456448)
31. D. Sibbing, O. von Beckerath, A. Schmig, A. Kastrati, N. von Beckerath Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention Am J Cardiol 100 2007 203 205 (Pubitemid 47041981)