Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease

Parkinsonism and Related Disorders

Volumn 25, Issue , 2016, Pages 58-64

  Martinez Horta, Saul ^a,b,c,e   Perez Perez, Jesus ^a,b,c   van Duijn, Erik ^d   Fernandez Bobadilla, Ramon ^a,b,c,e   Carceller, Mar ^a,b   Pagonabarraga, Javier ^a,b,c   Pascual Sedano, Berta ^a,b,c   Campolongo, Antonia ^a,b,c   Ruiz Idiago, Jesus ^f   Sampedro, Frederic ^a   Landwehrmeyer, G Bernhard ^g   Kulisevsky, Jaime ^a,b,c,e  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^c CIBERNED Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas   (Spain)

^d LEIDEN UNIVERSITY   (Netherlands)

^e UNIVERSITAT OBERTA DE CATALUNYA   (Spain)

^f Hospital Mare de Deu de La Merced   (Spain)

^g UNIVERSITY OF ULM   (Germany)

Author keywords

Apathy; Behavior; Biomarker; Huntington's disease; Neuropsychiatry

Indexed keywords

ADULT; AGED; APATHY; ARTICLE; BEHAVIOR; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; EXECUTIVE DYSFUNCTION; EXECUTIVE FUNCTION; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROLOGIC EXAMINATION; NEUROPSYCHIATRIC SYMPTOM; PREVALENCE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; SPAIN; SYMPTOM; COGNITION DISORDERS; COMPLICATION; PROSPECTIVE STUDY; PSYCHOLOGY;

ADULT; APATHY; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; DEPRESSION; EXECUTIVE FUNCTION; FEMALE; HUMANS; HUNTINGTON DISEASE; IRRITABLE MOOD; MALE; PREVALENCE; PROSPECTIVE STUDIES;

EID: 84958279371     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2016.02.008     Document Type: Article

References (30)

1. [1] Walker, F.O., Huntington's disease. Lancet 369 (2007), 218–228.
2. [2] Kulisevsky, J., Litvan, I., Berthier, M.L., Pascual-Sedano, B., Paulsen, J.S., Cummings, J.L., Neuropsychiatric assessment of Gilles de la Tourette patients: comparative study with other hyperkinetic and hypokinetic movement disorders. Mov. disord. Off. J. Mov. Disord. Soc. 16 (2001), 1098–1104.
3. [3] Craufurd, D., Thompson, J.C., Snowden, J.S., Behavioral changes in Huntington disease. Neuropsychiatry, Neuropsychol., Behav. Neurol. 14 (2001), 219–226.
4. [4] Kingma, E.M., van Duijn, E., Timman, R., van der Mast, R.C., Roos, R.A., Behavioural problems in Huntington's disease using the problem behaviours assessment. Gen. Hosp. psychiatry 30 (2008), 155–161.
5. [5] van Duijn, E., Kingma, E.M., van der Mast, R.C., Psychopathology in verified Huntington's disease gene carriers. J. Neuropsychiatry Clin. Neurosci. 19 (2007), 441–448.
6. [6] A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 72 (1993), 971–983.
7. [7] Tabrizi, S.J., Langbehn, D.R., Leavitt, B.R., Roos, R.A., Durr, A., Craufurd, D., et al. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol. 8 (2009), 791–801.
8. [8] Nopoulos, P.C., Aylward, E.H., Ross, C.A., Johnson, H.J., Magnotta, V.A., Juhl, A.R., et al. Cerebral cortex structure in prodromal Huntington disease. Neurobiol. Dis. 40 (2010), 544–554.
9. [9] Tabrizi, S.J., Scahill, R.I., Durr, A., Roos, R.A., Leavitt, B.R., Jones, R., et al. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 10 (2011), 31–42.
10. [10] Tabrizi, S.J., Reilmann, R., Roos, R.A., Durr, A., Leavitt, B., Owen, G., et al. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurol. 11 (2012), 42–53.
11. [11] van Duijn, E., Reedeker, N., Giltay, E.J., Roos, R.A., van der Mast, R.C., Correlates of apathy in Huntington's disease. J. Neuropsychiatry Clin. Neurosci. 22 (2010), 287–294.
12. [12] Duff, K., Paulsen, J.S., Beglinger, L.J., Langbehn, D.R., Stout, J.C., Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study. Biol. psychiatry 62 (2007), 1341–1346.
13. [13] van Duijn, E., Craufurd, D., Hubers, A.A., Giltay, E.J., Bonelli, R., Rickards, H., et al. Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY). J. Neurol., Neurosurg. Psychiatry 85 (2014), 1411–1418.
14. [14] Tabrizi, S.J., Scahill, R.I., Owen, G., Durr, A., Leavitt, B.R., Roos, R.A., et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 12 (2013), 637–649.
15. [15] Group HS, Unified Huntington's disease rating scale: reliability and consistency. huntington study group. Mov. Disord. Off. J. Mov. Disord. Soc. 11 (1996), 136–142.
16. [16] Orth, M., Handley, O.J., Schwenke, C., Dunnett, S., Wild, E.J., Tabrizi, S.J., et al. Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. J. Neurol., Neurosurg. psychiatry 82 (2011), 1409–1412.
17. [17] Langbehn, D.R., Brinkman, R.R., Falush, D., Paulsen, J.S., Hayden, M.R., A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin. Genet. 65 (2004), 267–277.
18. [18] Feigin, A., Kieburtz, K., Bordwell, K., Como, P., Steinberg, K., Sotack, J., et al. Functional decline in Huntington's disease. Mov. Disord. Off. J. Mov. Disord. Soc. 10 (1995), 211–214.
19. [19] Callaghan, J., Stopford, C., Arran, N., Boisse, M.F., Coleman, A., Santos, R.D., et al. Reliability and factor structure of the short problem behaviors assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies. J. Neuropsychiatry Clin. Neurosci. 27 (2015), 59–64.
20. [20] Sprengelmeyer, R., Orth, M., Muller, H.P., Wolf, R.C., Gron, G., Depping, M.S., et al. The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study. Psychol. Med. 44 (2014), 1867–1878.
21. [21] van der Meer, L., van Duijn, E., Wolterbeek, R., Tibben, A., Offspring of a parent with genetic disease: childhood experiences and adult psychological characteristics. Health Psychol. Off. J. Div. Health Psychol. Am. Psychol. Assoc. 33 (2014), 1445–1453.
22. [22] Vamos, M., Hambridge, J., Edwards, M., Conaghan, J., The impact of Huntington's disease on family life. Psychosomatics 48 (2007), 400–404.
23. [23] Thompson, J.C., Harris, J., Sollom, A.C., Stopford, C.L., Howard, E., Snowden, J.S., et al. Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease. J. Neuropsychiatry Clin. Neurosci. 24 (2012), 53–60.
24. [24] Ross, C.A., Tabrizi, S.J., Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol. 10 (2011), 83–98.
25. [25] Marder, K., Zhao, H., Myers, R.H., Cudkowicz, M., Kayson, E., Kieburtz, K., et al. Rate of functional decline in Huntington's disease. Huntington study group. Neurology 54 (2000), 452–458.
26. [26] Aron, A.R., Schlaghecken, F., Fletcher, P.C., Bullmore, E.T., Eimer, M., Barker, R., et al. Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease. Brain A J. Neurol. 126 (2003), 713–723.
27. [27] Wolf, R.C., Vasic, N., Schonfeldt-Lecuona, C., Landwehrmeyer, G.B., Ecker, D., Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI. Brain A J. Neurol. 130 (2007), 2845–2857.
28. [28] Marshall, J., White, K., Weaver, M., Flury Wetherill, L., Hui, S., Stout, J.C., et al. Specific psychiatric manifestations among preclinical Huntington disease mutation carriers. Archives Neurol. 64 (2007), 116–121.
29. [29] Martinez-Horta, S., Pagonabarraga, J., Fernandez de Bobadilla, R., Garcia-Sanchez, C., Kulisevsky, J., Apathy in Parkinson's disease: more than just executive dysfunction. J. Int. Neuropsychol. Soc. JINS 19 (2013), 571–582.
30. [30] Levy, R., Czernecki, V., Apathy and the basal ganglia. J. Neurol. 253:Suppl. 7 (2006), VII54–VII61.