A Single-Arm, Proof-Of-Concept Trial of Lopimune (Lopinavir/Ritonavir) as a Treatment for HPV-Related Pre-Invasive Cervical Disease

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Hampson, Lynne ^a   Maranga, Innocent O ^b,c   Masinde, Millicent S ^c   Oliver, Anthony W ^a   Batman, Gavin ^a   He, Xiaotong ^a   Desai, Minaxi ^d   Okemwa, Parmenas M ^c   Stringfellow, Helen ^e   Martin Hirsch, Pierre ^e   Mwaniki, Alex M ^c   Gichangi, Peter ^c   Hampson, Ian N ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b KENYATTA NATIONAL HOSPITAL   (Kenya)

^c UNIVERSITY OF NAIROBI   (Kenya)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^e ROYAL PRESTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LOPINAVIR PLUS RITONAVIR; ANTIVIRUS AGENT; DRUG COMBINATION; LOPINAVIR; LOPINAVIR-RITONAVIR DRUG COMBINATION; RITONAVIR;

ABDOMINAL PAIN; ABNORMAL FECES; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLPOSCOPY; DECREASED APPETITE; DIARRHEA; DIZZINESS; DRUG EFFICACY; DRUG SAFETY; DRUG SELF ADMINISTRATION; DRUG TOLERABILITY; DYSPAREUNIA; FAINTNESS; FEMALE; HEADACHE; HEART PALPITATION; HUMAN; HUMAN PAPILLOMAVIRUS DNA TEST; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 33; HUMAN PAPILLOMAVIRUS TYPE 35; HUMAN PAPILLOMAVIRUS TYPE 52; HUMAN PAPILLOMAVIRUS TYPE 58; HUMAN TISSUE; JAUNDICE; MAXIMUM PLASMA CONCENTRATION; MEDICATION COMPLIANCE; MICTURITION DISORDER; NAUSEA; PAPILLOMAVIRUS INFECTION; PATIENT COMPLIANCE; POLYDIPSIA; PUNCH BIOPSY; RASH; SKIN PRURITUS; SPOTTING; SQUAMOUS INTRAEPITHELIAL LESION OF THE CERVIX; THORAX PAIN; UTERINE CERVIX CYTOLOGY; UTERINE CERVIX DYSPLASIA; VAGINA BLEEDING; VAGINA DISCHARGE; VAGINA DISEASE; VAGINA PESSARY; VAGINA SMEAR KIT; VAGINAL DRYNESS; VAGINAL IRRITATION; VISUAL DISORDER; VOMITING; WEAKNESS; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECTS; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; INTRAVAGINAL DRUG ADMINISTRATION; KENYA; MOLECULAR TYPING; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PATHOLOGY; PATIENT ATTITUDE; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX; SQUAMOUS INTRAEPITHELIAL LESIONS OF THE CERVIX; TREATMENT OUTCOME; UTERINE CERVIX; VIROLOGY;

ADMINISTRATION, INTRAVAGINAL; ADULT; ANTIVIRAL AGENTS; CERVIX UTERI; COLPOSCOPY; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; GENOTYPE; HUMANS; KENYA; LOPINAVIR; MOLECULAR TYPING; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PATIENT ACCEPTANCE OF HEALTH CARE; RITONAVIR; SELF ADMINISTRATION; SEVERITY OF ILLNESS INDEX; SQUAMOUS INTRAEPITHELIAL LESIONS OF THE CERVIX; TREATMENT OUTCOME;

EID: 84958231527     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147917     Document Type: Article

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