Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia

Taiwanese Journal of Obstetrics and Gynecology

Volumn 51, Issue 4, 2012, Pages 533-538

  Lin, Cheng Tao ^a   Qiu, Jian Tai ^a,b   Wang, Chin Jung ^a   Chang, Shuenn Dyh ^a   Tang, Yun Hsin ^a   Wu, Pei Ju ^a   Jung, Shih Ming ^a   Huang, Chu Chun ^a   Chou, Hung Hsueh ^a   Jao, Mei Shan ^a   Lai, Chyong Huey ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cervical intraepithelial neoplasia; Human papillomavirus; Imiquimod; Vaginal intraepithelial neoplasia

Indexed keywords

IMIQUIMOD; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER REGRESSION; COLPOSCOPY; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; OUTPATIENT; PAPANICOLAOU TEST; PAPILLOMAVIRUS INFECTION; TREATMENT DURATION; UTERINE CERVIX CARCINOMA IN SITU; VAGINAL INTRAEPITHELIAL NEOPLASIA;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; AMINOQUINOLINES; CARCINOMA IN SITU; DNA, VIRAL; FEMALE; HUMANS; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; RETROSPECTIVE STUDIES; UTERINE CERVICAL NEOPLASMS; VAGINAL NEOPLASMS;

EID: 84871721857     PISSN: 10284559     EISSN: 18756263     Source Type: Journal    
DOI: 10.1016/j.tjog.2012.09.006     Document Type: Article

References (31)

1. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2:342-350.
2. Cuzick J., Szarewski A., Terry G., Ho L., Hanby A., Maddox P., et al. Human papillomavirus testing in primary cervical screening. Lancet 1995, 345:1533-1536.
3. Lai C.H., Chao A., Chang C.J., Chao F.Y., Huang H.J., Hsueh S., et al. Host and viral factors in relation to clearance of human papillomavirus infection: a cohort study in Taiwan. Int J Cancer 2008, 123:1685-1692.
4. Schiffman M., Rodriguez A.C., Chen Z., Wacholder S., Herrero R., Hildesheim A., et al. A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 2010, 70:3159-3169.
5. Solomon D., Papillo J.L., Davey D.D. Statement on HPV DNA test utilization. Diagn Cytopathol 2009, 37:542-543.
6. Chao A., Lin C.T., Hsueh S., Hong J.H., Hsueh S., Tseng C.J., et al. Usefulness of human papillomavirus testing in the follow-up of patients with high-grade cervical intraepithelial neoplasia after conization. Am J Obstet Gynecol 2004, 190:1046-1051.
7. von Keyserling H., Kaufmann A.M., Schneider A. HPV testing in the follow-up after treatment of women with CIN. Gynecol Oncol 2007, 107:S5-S7.
8. Balamurugan A., Ahmed F., Saraiya M., Kosary C., Schwenn M., Cokkinides V., et al. Potential role of human papillomavirus in the development of subsequent primary in situ and invasive cancers among cervical cancer survivors. Cancer 2008, 113:2919-2925.
9. Kjaer S.K., Frederiksen K., Munk C., Iftner T. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence. J Natl Cancer Inst 2010, 102:1478-1488.
10. De Vuyst H., Clifford G.M., Nascimento M.C., Madeleine M.M., Franceschi S. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer 2009, 124:1626-1636.
11. Dodge J.A., Eltabbakh G.H., Mount S.L., Walker R.P., Morgan A. Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia. Gynecol Oncol 2001, 83:363-369.
12. Aho M., Vesterinen E., Meyer B., Purola E., Paavonen J. Natural history of vaginal intraepithelial neoplasia. Cancer 1991, 68:195-197.
13. Logani S., Lu D., Quint W.G., Ellenson L.H., Pirog E.C. Low-grade vulvar and vaginal intraepithelial neoplasia: correlation of histologic features with human papillomavirus DNA detection and MIB-1 immunostaining. Mod Pathol 2003, 16:735-741.
14. Wright T.C., Massad L.S., Dunton C.J., Spitzer M., Wilkinson E.J., Solomon D., et al. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol 2007, 197:346-355.
15. Creasman W. Preinvasive disease of the vagina and vulva and related disorders. Clinical gynecologic oncology 2007, 37-54. Mosby Elsevier, Philadelphia. 7th ed. P. DiSaia, W. Creasman (Eds.).
16. Rome R.M., England P.G. Management of vaginal intraepithelial neoplasia: a series of 132 cases with long-term follow-up. Int J Gynecol Cancer 2000, 10:382-390.
17. Tyring S.K., Arany I., Stanley M.A., Tomai M.A., Miller R.L., Smith M.H., et al. A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod. J Infect Dis 1998, 178:551-555.
18. Edwards L., Ferenczy A., Eron L., Baker D., Owens M.L., Fox T.L., et al. Self-administered topical 5% imiquimod cream for external anogenital warts. HPV Study Group. Human PapillomaVirus. Arch Dermatol 1998, 134:25-30.
19. Allam J.P., Erdsach T., Wenghoefer M., Bieber T., Appel T.R., Novak N. Successful treatment of extensive human papillomavirus-associated oral leucoplakia with imiquimod. Br J Dermatol 2008, 158:644-646.
20. Vidal D., Matías-Guiu X., Alomar A. Open study of the efficacy and mechanism of action of topical imiquimod in basal cell carcinoma. Clin Exp Dermatol 2004, 29:518-525.
21. van Seters M., van Beurden M., ten Kate F.J., Beckmann I., Ewing P.C., Eijkemans M.J., et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med 2008, 358:1465-1473.
22. Todd R.W., Etherington I.J., Luesley D.M. The effects of 5% imiquimod cream on high-grade vulval intraepithelial neoplasia. Gynecol Oncol 2002, 85:67-70.
23. Buck H.W., Guth K.J. Treatment of vaginal intraepithelial neoplasia (primarily low grade) with imiquimod 5% cream. J Low Genit Tract Dis 2003, 7:290-293.
24. Diakomanolis E., Haidopoulos D., Stefanidis K. Treatment of high-grade vaginal intraepithelial neoplasia with imiquimod cream. N Engl J Med 2002, 347:374.
25. Diaz-Arrastia C., Arany I., Robazetti S.C., Dinh T.V., Gatalica Z., Tyring S.K., et al. Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%. Clin Cancer Res 2001, 7:3031-3033.
26. Haidopoulos D., Diakomanolis E., Rodolakis A., Voulgaris Z., Vlachos G., Intsaklis A. Can local application of imiquimod cream be an alternative mode of therapy for patients with high-grade intraepithelial lesions of the vagina?. Int J Gynecol Cancer 2005, 15:898-902.
27. Chuang C.M., Monie A., Hung C.F., Wu T.C. Treatment with imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination. J Biomed Sci 2010, 17:32-40.
28. Huang S.L., Chao A., Hsueh S., Chao F.U., Huang C.C., Yang J.E., et al. Comparison between the Hybrid Capture II Test and a SPF1/GP6+ PCR-based assay for detection of human papillomavirus DNA in cervical swab samples. J Clin Microbiol 2006, 44:1733-1739.
29. Chao A., Hsu K.H., Lai C.H., Huang H.J., Hsueh S., Lin S.R., et al. Cervical cancer screening program integrating Pap smear and HPV DNA testing: a population-based study. Int J Cancer 2008, 122:2835-2841.
30. Kitchener H.C., Walker P.G., Nelson L., Hadwin R., Patnick J., Anthony G.B., et al. HPV testing as an adjunct to cytology in the follow up of women treated for cervical intraepithelial neoplasia. BJOG 2008, 115:1001-1007.
31. Iavazzo C., Pitsouni E., Athanasiou S., Falagas M.E. Imiquimod for treatment of vulvar and vaginal intraepithelial neoplasia. Int J Gynaecol Obstet 2008, 101:3-10.