Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2

Neuron

Volumn 89, Issue 4, 2016, Pages 725-733

  Hoffman, Ellen J ^a,b   Turner, Katherine J ^c   Fernandez, Joseph M ^a,b   Cifuentes, Daniel ^b,d   Ghosh, Marcus ^c   Ijaz, Sundas ^a,b   Jain, Roshan A ^e,f   Kubo, Fumi ^g   Bill, Brent R ^h,i   Baier, Herwig ^g   Granato, Michael ^e   Barresi, Michael J F ^j   Wilson, Stephen W ^c   Rihel, Jason ^c   State, Matthew W ^a,b,k   Giraldez, Antonio J ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f HAVERFORD COLLEGE   (United States)

^g MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF TEXAS AT TYLER   (United States)

^j SMITH COLLEGE   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHANIN A; ESTRADIOL; ESTRADIOL CIPIONATE; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR AGONIST; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; CNTNAP2 PROTEIN, HUMAN; ESTROGEN; FLUORESCENT PROTEIN 583; GENISTEIN; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; PHOTOPROTEIN; PHYTOESTROGEN; PSYCHOTROPIC AGENT; VESICULAR GLUTAMATE TRANSPORTER 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BEHAVIOR DISORDER; CNTNAP2 GENE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; ESTROGEN ACTIVITY; FOREBRAIN; GABAERGIC SYSTEM; GENE; GENE ACTIVITY; GENE FUNCTION; GENE LOSS; HIGH THROUGHPUT SCREENING; HYPERACTIVITY; MUTANT; NONHUMAN; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEIZURE; ZEBRA FISH; ANIMAL; AUTISTIC DISORDER; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LARVA; METABOLISM; MOTOR ACTIVITY; MUTATION; SEIZURES; SLEEP-WAKE TRANSITION DISORDERS; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTISTIC DISORDER; DISEASE MODELS, ANIMAL; ESTROGENS; GENE EXPRESSION REGULATION; GENISTEIN; GREEN FLUORESCENT PROTEINS; HUMANS; LARVA; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MOTOR ACTIVITY; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; PHYTOESTROGENS; PSYCHOTROPIC DRUGS; SEIZURES; SLEEP-WAKE TRANSITION DISORDERS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2; ZEBRAFISH;

EID: 84958212452     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.12.039     Document Type: Article

References (28)

1. Ablain J., Zon L.I. Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013, 23:584-586.
2. Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Association, American Psychiatric Publishing, Arlington. Fifth Edition.
3. Baraban S.C., Taylor M.R., Castro P.A., Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 2005, 131:759-768.
4. Baron-Cohen S., Lombardo M.V., Auyeung B., Ashwin E., Chakrabarti B., Knickmeyer R. Why are autism spectrum conditions more prevalent in males?. PLoS Biol. 2011, 9:e1001081.
5. Cobos I., Calcagnotto M.E., Vilaythong A.J., Thwin M.T., Noebels J.L., Baraban S.C., Rubenstein J.L. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat. Neurosci. 2005, 8:1059-1068.
6. De Rubeis S., He X., Goldberg A.P., Poultney C.S., Samocha K., Cicek A.E., Kou Y., Liu L., Fromer M., Walker S., et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 2014, 515:209-215. DDD Study, Homozygosity Mapping Collaborative for AutismHomozygosity Mapping Collaborative for Autism, UK10K ConsortiumUK10K Consortium.
7. Ghanem N., Jarinova O., Amores A., Long Q., Hatch G., Park B.K., Rubenstein J.L., Ekker M. Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res. 2003, 13:533-543.
8. Iossifov I., O'Roak B.J., Sanders S.J., Ronemus M., Krumm N., Levy D., Stessman H.A., Witherspoon K.T., Vives L., Patterson K.E., et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature 2014, 515:216-221.
9. Jacquemont S., Coe B.P., Hersch M., Duyzend M.H., Krumm N., Bergmann S., Beckmann J.S., Rosenfeld J.A., Eichler E.E. A higher mutational burden in females supports a "female protective model" in neurodevelopmental disorders. Am. J. Hum. Genet. 2014, 94:415-425.
10. Keilhoff G., Becker A., Grecksch G., Wolf G., Bernstein H.G. Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia. Neuroscience 2004, 126:591-598.
11. Kinkhabwala A., Riley M., Koyama M., Monen J., Satou C., Kimura Y., Higashijima S., Fetcho J. A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proc. Natl. Acad. Sci. U S A 2011, 108:1164-1169.
12. Kokel D., Peterson R.T. Using the zebrafish photomotor response for psychotropic drug screening. Methods Cell Biol. 2011, 105:517-524.
13. Marino M., Galluzzo P., Ascenzi P. Estrogen signaling multiple pathways to impact gene transcription. Curr. Genomics 2006, 7:497-508.
14. McCracken J.T., McGough J., Shah B., Cronin P., Hong D., Aman M.G., Arnold L.E., Lindsay R., Nash P., Hollway J., et al. Risperidone in children with autism and serious behavioral problems. N. Engl. J. Med. 2002, 347:314-321. Research Units on Pediatric Psychopharmacology Autism Network.
15. Parikshak N.N., Luo R., Zhang A., Won H., Lowe J.K., Chandran V., Horvath S., Geschwind D.H. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell 2013, 155:1008-1021.
16. Peñagarikano O., Abrahams B.S., Herman E.I., Winden K.D., Gdalyahu A., Dong H., Sonnenblick L.I., Gruver R., Almajano J., Bragin A., et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell 2011, 147:235-246.
17. Poliak S., Salomon D., Elhanany H., Sabanay H., Kiernan B., Pevny L., Stewart C.L., Xu X., Chiu S.Y., Shrager P., et al. Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 2003, 162:1149-1160.
18. Prober D.A., Rihel J., Onah A.A., Sung R.J., Schier A.F. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J. Neurosci. 2006, 26:13400-13410.
19. Rihel J., Prober D.A., Arvanites A., Lam K., Zimmerman S., Jang S., Haggarty S.J., Kokel D., Rubin L.L., Peterson R.T., Schier A.F. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010, 327:348-351.
20. Rubenstein J.L., Merzenich M.M. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003, 2:255-267.
21. Sanders S.J., He X., Willsey A.J., Ercan-Sencicek A.G., Samocha K.E., Cicek A.E., Murtha M.T., Bal V.H., Bishop S.L., Dong S., et al. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron 2015, 87:1215-1233. Autism Sequencing Consortium.
22. Saunders J.A., Tatard-Leitman V.M., Suh J., Billingslea E.N., Roberts T.P., Siegel S.J. Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes. Autism Res. 2013, 6:69-77.
23. Schaafsma S.M., Pfaff D.W. Etiologies underlying sex differences in Autism Spectrum Disorders. Front. Neuroendocrinol. 2014, 35:255-271.
24. Smith C.C., Vedder L.C., McMahon L.L. Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses. Psychoneuroendocrinology 2009, 34(Suppl 1):S130-S142.
25. Strauss K.A., Puffenberger E.G., Huentelman M.J., Gottlieb S., Dobrin S.E., Parod J.M., Stephan D.A., Morton D.H. Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N. Engl. J. Med. 2006, 354:1370-1377.
26. Watanabe Y., Takechi K., Fujiwara A., Kamei C. Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice. J. Pharmacol. Sci. 2010, 112:282-289.
27. Willsey A.J., Sanders S.J., Li M., Dong S., Tebbenkamp A.T., Muhle R.A., Reilly S.K., Lin L., Fertuzinhos S., Miller J.A., et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 2013, 155:997-1007.
28. Zerucha T., Stühmer T., Hatch G., Park B.K., Long Q., Yu G., Gambarotta A., Schultz J.R., Rubenstein J.L., Ekker M. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J. Neurosci. 2000, 20:709-721.