메뉴 건너뛰기




Volumn 127, Issue 5, 2016, Pages 646-657

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CALCINEURIN INHIBITOR; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FLUDARABINE; METHOTREXATE; MYCOPHENOLATE MOFETIL; PROTEIN BCL 2; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

EID: 84958191434     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-10-672345     Document Type: Article
Times cited : (138)

References (47)
  • 1
    • 77953011655 scopus 로고    scopus 로고
    • Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: An update
    • Seggewiss R, Einsele H. Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: An update. Blood. 2010;115(19):3861-3868.
    • (2011) Blood , vol.115 , Issue.19 , pp. 3861-3868
    • Seggewiss, R.1    Einsele, H.2
  • 2
    • 33745053619 scopus 로고    scopus 로고
    • Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation
    • Kim DH, Sohn SK, Won DI, Lee NY, Suh JS, Lee KB. Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation. Bone Marrow Transplant. 2006;37(12):1119-1128.
    • (2006) Bone Marrow Transplant , vol.37 , Issue.12 , pp. 1119-1128
    • Kim, D.H.1    Sohn, S.K.2    Won, D.I.3    Lee, N.Y.4    Suh, J.S.5    Lee, K.B.6
  • 3
    • 57249094209 scopus 로고    scopus 로고
    • Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
    • Storek J, Geddes M, Khan F, et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. Semin Immunopathol. 2008;30(4):425-437.
    • (2008) Semin Immunopathol , vol.30 , Issue.4 , pp. 425-437
    • Storek, J.1    Geddes, M.2    Khan, F.3
  • 4
    • 84895780508 scopus 로고    scopus 로고
    • Immune cell subset counts associated with graft-versus-host disease
    • Podgorny PJ, Liu Y, Dharmani-Khan P, et al. Immune cell subset counts associated with graft-versus-host disease. Biol Blood Marrow Transplant. 2014;20(4):450-462.
    • (2014) Biol Blood Marrow Transplant , vol.20 , Issue.4 , pp. 450-462
    • Podgorny, P.J.1    Liu, Y.2    Dharmani-Khan, P.3
  • 5
    • 41349097096 scopus 로고    scopus 로고
    • Escape from suppression: Tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation
    • Mirmonsef P, Tan G, Zhou G, et al. Escape from suppression: Tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation. Blood. 2008;111(4):2112-2121.
    • (2008) Blood , vol.111 , Issue.4 , pp. 2112-2121
    • Mirmonsef, P.1    Tan, G.2    Zhou, G.3
  • 6
    • 84886573982 scopus 로고    scopus 로고
    • Multiparameter single-cell profiling of human CD41FOXP31 regulatory T-cell populations in homeostatic conditions and during graft-versushost disease
    • Dong S, Maiella S, Xhaard A, et al. Multiparameter single-cell profiling of human CD41FOXP31 regulatory T-cell populations in homeostatic conditions and during graft-versushost disease. Blood. 2013;122(10):1802-1812.
    • (2013) Blood , vol.122 , Issue.10 , pp. 1802-1812
    • Dong, S.1    Maiella, S.2    Xhaard, A.3
  • 7
    • 84905711060 scopus 로고    scopus 로고
    • Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT
    • Xhaard A, Moins-Teisserenc H, Busson M, et al. Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT. Bone Marrow Transplant. 2014;49(8):1089-1092.
    • (2014) Bone Marrow Transplant , vol.49 , Issue.8 , pp. 1089-1092
    • Xhaard, A.1    Moins-Teisserenc, H.2    Busson, M.3
  • 8
    • 84908057745 scopus 로고    scopus 로고
    • Comparative analysis of FoxP3(1) regulatory T cells in the target tissues and blood in chronic graft versus host disease
    • Imanguli MM, Cowen EW, Rose J, et al. Comparative analysis of FoxP3(1) regulatory T cells in the target tissues and blood in chronic graft versus host disease. Leukemia. 2014;28(10):2016-2027.
    • (2014) Leukemia , vol.28 , Issue.10 , pp. 2016-2027
    • Imanguli, M.M.1    Cowen, E.W.2    Rose, J.3
  • 9
    • 84907356372 scopus 로고    scopus 로고
    • Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation
    • Murase K, Kim HT, Bascug OR, et al. Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation. Haematologica. 2014; 99(9):1499-1508.
    • (2014) Haematologica , vol.99 , Issue.9 , pp. 1499-1508
    • Murase, K.1    Kim, H.T.2    Bascug, O.R.3
  • 10
    • 84897945297 scopus 로고    scopus 로고
    • The importance of regulatory T-cell heterogeneity in maintaining selftolerance
    • Yuan X, Cheng G, Malek TR. The importance of regulatory T-cell heterogeneity in maintaining selftolerance. Immunol Rev. 2014;259(1):103-114.
    • (2014) Immunol Rev , vol.259 , Issue.1 , pp. 103-114
    • Yuan, X.1    Cheng, G.2    Malek, T.R.3
  • 11
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 12
    • 0141461418 scopus 로고    scopus 로고
    • CD41CD251 regulatory T cells preserve graftversus-Tumor activity while inhibiting graft-versushost disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, et al. CD41CD251 regulatory T cells preserve graftversus-Tumor activity while inhibiting graft-versushost disease after bone marrow transplantation. Nat Med. 2003;9(9):1144-1150.
    • (2003) Nat Med , vol.9 , Issue.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 13
    • 4644301368 scopus 로고    scopus 로고
    • Association of Foxp3 regulatory gene expression with graftversus-host disease
    • Miura Y, Thoburn CJ, Bright EC, et al. Association of Foxp3 regulatory gene expression with graftversus-host disease. Blood. 2004;104(7): 2187-2193.
    • (2004) Blood , vol.104 , Issue.7 , pp. 2187-2193
    • Miura, Y.1    Thoburn, C.J.2    Bright, E.C.3
  • 14
    • 27144500976 scopus 로고    scopus 로고
    • Reduced frequency of FOXP31 CD41CD251 regulatory T cells in patients with chronic graft-versus-host disease
    • Zorn E, Kim HT, Lee SJ, et al. Reduced frequency of FOXP31 CD41CD251 regulatory T cells in patients with chronic graft-versus-host disease. Blood. 2005;106(8):2903-2911.
    • (2005) Blood , vol.106 , Issue.8 , pp. 2903-2911
    • Zorn, E.1    Kim, H.T.2    Lee, S.J.3
  • 15
    • 84941702574 scopus 로고    scopus 로고
    • Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease
    • Bolton HA, Zhu E, Terry AM, et al. Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest. 2015;125(9):3627-3641.
    • (2015) J Clin Invest , vol.125 , Issue.9 , pp. 3627-3641
    • Bolton, H.A.1    Zhu, E.2    Terry, A.M.3
  • 16
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therapy
    • Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol. 2012;12(6):443-458.
    • (2012) Nat Rev Immunol , vol.12 , Issue.6 , pp. 443-458
    • Blazar, B.R.1    Murphy, W.J.2    Abedi, M.3
  • 17
    • 84904470709 scopus 로고    scopus 로고
    • Current issues in chronic graftversus-host disease
    • Socíe G, Ritz J. Current issues in chronic graftversus-host disease. Blood. 2014;124(3): 374-384.
    • (2014) Blood , vol.124 , Issue.3 , pp. 374-384
    • Socíe, G.1    Ritz, J.2
  • 19
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naive and memory T cells
    • Boyman O, Ĺetourneau S, Krieg C, Sprent J. Homeostatic proliferation and survival of naive and memory T cells. Eur J Immunol. 2009;39(8): 2088-2094.
    • (2009) Eur J Immunol , vol.39 , Issue.8 , pp. 2088-2094
    • Boyman, O.1    Ĺetourneau, S.2    Krieg, C.3    Sprent, J.4
  • 20
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29(6):848-862.
    • (2008) Immunity , vol.29 , Issue.6 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 21
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • Liston A, Gray DH. Homeostatic control of regulatory T cell diversity. Nat Rev Immunol. 2014;14(3):154-165.
    • (2014) Nat Rev Immunol , vol.14 , Issue.3 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 22
    • 79959529827 scopus 로고    scopus 로고
    • Thymic T-cell development in allogeneic stem cell transplantation
    • Krenger W, Blazar BR, Holländer GA. Thymic T-cell development in allogeneic stem cell transplantation. Blood. 2011;117(25):6768-6776.
    • (2011) Blood , vol.117 , Issue.25 , pp. 6768-6776
    • Krenger, W.1    Blazar, B.R.2    Holländer, G.A.3
  • 24
    • 72949100401 scopus 로고    scopus 로고
    • Naive T cell homeostasis: From awareness of space to a sense of place
    • Takada K, Jameson SC. Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol. 2009;9(12):823-832.
    • (2009) Nat Rev Immunol , vol.9 , Issue.12 , pp. 823-832
    • Takada, K.1    Jameson, S.C.2
  • 25
    • 38349146500 scopus 로고    scopus 로고
    • The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation
    • Nguyen VH, Shashidhar S, Chang DS, et al. The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation. Blood. 2008;111(2):945-953.
    • (2008) Blood , vol.111 , Issue.2 , pp. 945-953
    • Nguyen, V.H.1    Shashidhar, S.2    Chang, D.S.3
  • 26
    • 77951870520 scopus 로고    scopus 로고
    • Altered regulatory T cell homeostasis in patients with CD41 lymphopenia following allogeneic hematopoietic stem cell transplantation
    • Matsuoka K, Kim HT, McDonough S, et al. Altered regulatory T cell homeostasis in patients with CD41 lymphopenia following allogeneic hematopoietic stem cell transplantation. J Clin Invest. 2010;120(5):1479-1493.
    • (2011) J Clin Invest , vol.120 , Issue.5 , pp. 1479-1493
    • Matsuoka, K.1    Kim, H.T.2    McDonough, S.3
  • 27
    • 84910105185 scopus 로고    scopus 로고
    • Spatial map of human T cell compartmentalization and maintenance over decades of life
    • Thome JJ, Yudanin N, Ohmura Y, et al. Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell. 2014; 159(4):814-828.
    • (2014) Cell , vol.159 , Issue.4 , pp. 814-828
    • Thome, J.J.1    Yudanin, N.2    Ohmura, Y.3
  • 28
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401(6754): 708-712.
    • (1999) Nature , vol.401 , Issue.6754 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Förster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 30
    • 36249011444 scopus 로고    scopus 로고
    • Correlation between recent thymic emigrants and CD311 (PECAM-1) CD41 T cells in normal individuals during aging and in lymphopenic children
    • Junge S, Kloeckener-Gruissem B, Zufferey R, et al. Correlation between recent thymic emigrants and CD311 (PECAM-1) CD41 T cells in normal individuals during aging and in lymphopenic children. Eur J Immunol. 2007; 37(11):3270-3280.
    • (2007) Eur J Immunol , vol.37 , Issue.11 , pp. 3270-3280
    • Junge, S.1    Kloeckener-Gruissem, B.2    Zufferey, R.3
  • 31
    • 59649094871 scopus 로고    scopus 로고
    • Life after the thymus: CD311 and CD31-human naive CD41 T-cell subsets
    • Kohler S, Thiel A. Life after the thymus: CD311 and CD31-human naive CD41 T-cell subsets. Blood. 2009;113(4):769-774.
    • (2009) Blood , vol.113 , Issue.4 , pp. 769-774
    • Kohler, S.1    Thiel, A.2
  • 32
    • 0028327632 scopus 로고
    • The proliferation-Associated Ki-67 protein: Definition in molecular terms
    • Duchrow M, Gerdes J, Schlüter C. The proliferation-Associated Ki-67 protein: definition in molecular terms. Cell Prolif. 1994;27(5):235-242.
    • (1994) Cell Prolif , vol.27 , Issue.5 , pp. 235-242
    • Duchrow, M.1    Gerdes, J.2    Schlüter, C.3
  • 33
    • 0038021272 scopus 로고    scopus 로고
    • Control of apoptosis in the immune system: Bcl-2 BH3-only proteins and more
    • Marsden VS, Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol. 2003;21:71-105.
    • (2003) Annu Rev Immunol , vol.21 , pp. 71-105
    • Marsden, V.S.1    Strasser, A.2
  • 34
    • 80955167008 scopus 로고    scopus 로고
    • Low telomerase activity in CD41 regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation
    • Kawano Y, Kim HT, Matsuoka K, et al. Low telomerase activity in CD41 regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation. Blood. 2011;118(18):5021-5030.
    • (2011) Blood , vol.118 , Issue.18 , pp. 5021-5030
    • Kawano, Y.1    Kim, H.T.2    Matsuoka, K.3
  • 35
    • 84875489516 scopus 로고    scopus 로고
    • The biology of recent thymic emigrants
    • Fink PJ. The biology of recent thymic emigrants. Annu Rev Immunol. 2013;31:31-50.
    • (2013) Annu Rev Immunol , vol.31 , pp. 31-50
    • Fink, P.J.1
  • 36
    • 84929944502 scopus 로고    scopus 로고
    • Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors
    • Thiault N, Darrigues J, Adoue V, et al. Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors. Nat Immunol. 2015;16(6):628-634.
    • (2015) Nat Immunol , vol.16 , Issue.6 , pp. 628-634
    • Thiault, N.1    Darrigues, J.2    Adoue, V.3
  • 37
    • 84929950085 scopus 로고    scopus 로고
    • Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition
    • Weist BM, Kurd N, Boussier J, Chan SW, Robey EA. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 2015;16(6):635-641.
    • (2015) Nat Immunol , vol.16 , Issue.6 , pp. 635-641
    • Weist, B.M.1    Kurd, N.2    Boussier, J.3    Chan, S.W.4    Robey, E.A.5
  • 38
    • 85047691367 scopus 로고    scopus 로고
    • Memory CD41 T cells do not induce graft-versus-host disease
    • Anderson BE, McNiff J, Yan J, et al. Memory CD41 T cells do not induce graft-versus-host disease. J Clin Invest. 2003;112(1):101-108.
    • (2003) J Clin Invest , vol.112 , Issue.1 , pp. 101-108
    • Anderson, B.E.1    McNiff, J.2    Yan, J.3
  • 39
    • 84936806071 scopus 로고    scopus 로고
    • Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts
    • Bleakley M, Heimfeld S, Loeb KR, et al. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. J Clin Invest. 2015;125(7):2677-2689.
    • (2015) J Clin Invest , vol.125 , Issue.7 , pp. 2677-2689
    • Bleakley, M.1    Heimfeld, S.2    Loeb, K.R.3
  • 40
    • 84881265208 scopus 로고    scopus 로고
    • A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graftversus-host disease
    • Meyer EH, Hsu AR, Liliental J, et al. A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graftversus-host disease. Blood. 2013;121(24): 4955-4962.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4955-4962
    • Meyer, E.H.1    Hsu, A.R.2    Liliental, J.3
  • 41
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versushost disease
    • Matsuoka K, Koreth J, Kim HT, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versushost disease. Sci Transl Med. 2013;5(179): 179ra43.
    • (2013) Sci Transl Med , vol.5 , Issue.179 , pp. 179ra43
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3
  • 42
    • 79954504851 scopus 로고    scopus 로고
    • Clinical tolerance in allogeneic hematopoietic stem cell transplantation
    • Roncarolo MG, Gregori S, Lucarelli B, Ciceri F, Bacchetta R. Clinical tolerance in allogeneic hematopoietic stem cell transplantation. Immunol Rev. 2011;241(1):145-163.
    • (2011) Immunol Rev , vol.241 , Issue.1 , pp. 145-163
    • Roncarolo, M.G.1    Gregori, S.2    Lucarelli, B.3    Ciceri, F.4    Bacchetta, R.5
  • 43
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: Take a billion or so and call me in the morning
    • Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: Take a billion or so and call me in the morning. Immunity. 2009;30(5): 656-665.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 44
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • Koreth J, Matsuoka K, Kim HT, et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med. 2011;365(22):2055-2066.
    • (2011) N Engl J Med , vol.365 , Issue.22 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 45
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117(3): 1061-1070.
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 46
    • 84898940914 scopus 로고    scopus 로고
    • Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity
    • Kennedy-Nasser AA, Ku S, Castillo-Caro P, et al. Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin Cancer Res. 2014;20(8):2215-2225.
    • (2014) Clin Cancer Res , vol.20 , Issue.8 , pp. 2215-2225
    • Kennedy-Nasser, A.A.1    Ku, S.2    Castillo-Caro, P.3
  • 47
    • 84982091033 scopus 로고    scopus 로고
    • Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo
    • Parmar S, Liu X, Najjar A, et al. Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo. Blood. 2015;125(9):1502-1506.
    • (2015) Blood , vol.125 , Issue.9 , pp. 1502-1506
    • Parmar, S.1    Liu, X.2    Najjar, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.