Hematologic malignancies in mice

Blood

Volumn 127, Issue 3, 2016, Pages 310-313

  Vasanthakumar, Aparna ^a   Arnovitz, Stephen ^a   Marquez, Rafael ^a   Lepore, Janet ^a   Rafidi, George ^a   Asom, Anase ^a   Weatherly, Madison ^a   Davis, Elizabeth M ^a   Neistadt, Barbara ^a   Duszynski, Robert ^a   Vardiman, James W ^b   Beau, Michelle M L E ^a,c   Godley, Lucy A ^a,c,d   Churpek, Jane E ^a,c,d  

^a Department of Medicine   (United States)

^b Department of Pathology ^*  (United States)

^c University of Chicago   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; HEMOGLOBIN; MITOMYCIN;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW DEPRESSION; CONTROLLED STUDY; CYTOPENIA; DNA CROSS LINKING; DOUBLE STRANDED DNA BREAK; ERYTHROLEUKEMIA; FANCONI ANEMIA; GENE DELETION; GENOMIC INSTABILITY; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMOGLOBIN BLOOD LEVEL; IN VITRO STUDY; KARYOTYPE; LEUKOCYTE COUNT; LYMPHOMA; MACROCYTIC ANEMIA; MEAN CORPUSCULAR VOLUME; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; ANIMAL; APLASTIC ANEMIA; BONE MARROW; BONE MARROW CELL; BONE MARROW DISEASE; DEFICIENCY; DISEASE MODEL; GENETICS; HEMATOLOGIC NEOPLASMS; HEMOGLOBINURIA, PAROXYSMAL; HUMAN; KNOCKOUT MOUSE; LEUKEMIC INFILTRATION; METABOLISM; PANCYTOPENIA; PATHOLOGY; PHENOTYPE;

ANEMIA, APLASTIC; ANIMALS; BONE MARROW; BONE MARROW CELLS; BONE MARROW DISEASES; BRCA1 PROTEIN; DISEASE MODELS, ANIMAL; GENOMIC INSTABILITY; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; LEUKEMIC INFILTRATION; LEUKOCYTE COUNT; MICE; MICE, KNOCKOUT; PANCYTOPENIA; PHENOTYPE;

EID: 84958155236     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-03-635599     Document Type: Article

References (20)

1. Walden H, Deans AJ. The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder. Annu Rev Biophys. 2014;43:257-278.
2. Wang B. BRCA1 tumor suppressor network: focusing on its tail. Cell Biosci. 2012;2(1):6.
3. D'Andrea AD. BRCA1: A missing link in the Fanconi anemia/BRCA pathway. Cancer Discov. 2013;3(4):376-378.
4. Sawyer SL, Tian L, Kähk önen M, Schwartzentruber J, Kircher M. Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype. Cancer Discov. 2015;5(2):135-142.
5. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994; 266(5182):66-71.
6. Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
7. Deutsch E, Jarrousse S, Buet D, et al. Downregulation of BRCA1 in BCR-ABL-expressing hematopoietic cells. Blood. 2003;101(11): 4583-4588.
8. Scardocci A, Guidi F, D'Alo' F, et al. Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia. Br J Cancer. 2006;95(8):1108-1113.
9. Bai L, Shi G, Zhang X, Dong W, Zhang L. Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function. Exp Cell Res. 2013; 319(17):2739-2746.
10. Domchek SM, Tang J, Stopfer J, et al. Biallelic deleterious BRCA1 mutations in a woman with early-onset ovarian cancer. Cancer Discov. 2013; 3(4):399-405.
11. McCarthy A, Savage K, Gabriel A, Naceur C, Reis-Filho JS, Ashworth A. A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol. 2007;211(4):389-398.
12. Kühn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995; 269(5229):1427-1429.
13. Vasanthakumar A, Lepore JB, Zegarek MH, et al. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood. 2013;121(11):2059-2063.
14. Kogan SC, Ward JM, Anver MR, et al; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002; 100(1):238-245.
15. Morse HC III, Anver MR, Fredrickson TN, et al; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002;100(1):246-258.
16. Alter BP, Knobloch ME, Weinberg RS. Erythropoiesis in Fanconi's anemia. Blood. 1991;78(3):602-608.
17. D'Andrea AD, Grompe M. Molecular biology of Fanconi anemia: implications for diagnosis and therapy. Blood. 1997;90(5):1725-1736.
18. Parmar K, D'Andrea A, Niedernhofer LJ. Mouse models of Fanconi anemia. Mutat Res. 2009; 668(1-2):133-140.
19. Parmar K, Kim J, Sykes SM, et al. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells. 2010;28(7): 1186-1195.
20. Garaycoechea JI, Patel KJ. Why does the bone marrow fail in Fanconi anemia? Blood. 2014; 123(1):26-34.