Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells

Journal of Cellular Physiology

Volumn 231, Issue 6, 2016, Pages 1334-1342

  Grossi, Mario ^a   Phanstiel, Otto ^b   Rippe, Catarina ^a   Swärd, Karl ^a   Alajbegovic, Azra ^a   Albinsson, Sebastian ^a   Forte, Amalia ^c   Persson, Lo ^a   Hellstrand, Per ^a   Nilsson, Bengt Olof ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; DIAMINE DERIVATIVE; EFLORNITHINE; N1,N1',N1'' [BENZENE 1,3,5 TRIYLTRIS(METHYLENE)]TRIS[N4 (4 METHYLAMINO)BUTYL]BUTANE 1,4 DIAMINE; POLYAMINE; POLYAMINE TRANSPORTER INHIBITOR; PUTRESCINE; SPERMIDINE; UNCLASSIFIED DRUG; CAV1 PROTEIN, MOUSE; CAVEOLIN 1; N1,N1',N1''-(BENZENE-1,3,5-TRIYLTRIS(METHYLENE))TRIS(N4-(4-(METHYLAMINO)BUTYL)BUTANE-1,4-DIAMINE; ORNITHINE DECARBOXYLASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; AORTA; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY MUSCLE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG TARGETING; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; LIMIT OF DETECTION; MARKER GENE; MOUSE; MUSCLE FIBER CONTRACTION; NONHUMAN; PHENOTYPE; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; RESTENOSIS; SENSITIVITY AND SPECIFICITY; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; SMOOTH MUSCLE CELL; TIME FACTOR; TISSUE CULTURE TECHNIQUE; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANIMALS; BIOGENIC POLYAMINES; BIOLOGICAL TRANSPORT; CAVEOLIN 1; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EFLORNITHINE; GENE EXPRESSION REGULATION; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ORNITHINE DECARBOXYLASE INHIBITORS; PHENOTYPE; POLYAMINES; PUTRESCINE; SPERMIDINE; TIME FACTORS; TISSUE CULTURE TECHNIQUES; VASOCONSTRICTION;

EID: 84958113434     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25236     Document Type: Article

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