Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers

American Journal of Nephrology

Volumn 42, Issue 6, 2015, Pages 436-442

  Little, Dustin J ^a   Yuan, Christina M ^a   Thurlow, John S ^f   Gounden, Verena ^b   Doi, Sonia Q ^c   Pruziner, Alison ^d   Abbott, Kevin C ^e   Theeler, Brett J ^a   Olson, Stephen W ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d Department of Defense and Veterans Affairs Extremity Trauma and Amputation Center of Excellence   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f WILLIAM BEAUMONT ARMY MEDICAL CENTER   (United States)

Author keywords

Amputation; Beta 2 microglobulin; Beta trace protein; Glomerular filtration rate estimation

Indexed keywords

BETA 2 MICROGLOBULIN; BETA TRACE PROTEIN; BIOLOGICAL MARKER; CREATININE; CYSTATIN C; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; ISOMERASE; LIPOCALIN; PROSTAGLANDIN R2 D-ISOMERASE;

ADULT; ARTICLE; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DISABLED PERSON; DUAL ENERGY X RAY ABSORPTIOMETRY; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MALE; NEPHELOMETRY; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SKELETAL MUSCLE; SOLDIER; TRAUMATIC AMPUTATION; WEIGHT REDUCTION; ADOLESCENT; BLOOD; BRAIN INJURY; CASE CONTROL STUDY; FEMALE; KIDNEY FUNCTION TEST; MIDDLE AGED; PHOTOMETRY; PHOTON ABSORPTIOMETRY; REGISTER; STATISTICAL MODEL; UNITED STATES; YOUNG ADULT;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; AMPUTATION, TRAUMATIC; BETA 2-MICROGLOBULIN; BODY WEIGHT; BRAIN INJURIES; CASE-CONTROL STUDIES; CREATININE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; KIDNEY FUNCTION TESTS; LIPOCALINS; MALE; MIDDLE AGED; MILITARY PERSONNEL; MODELS, STATISTICAL; NEPHELOMETRY AND TURBIDIMETRY; REGISTRIES; UNITED STATES; WEIGHT LOSS; YOUNG ADULT;

EID: 84958105333     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000443775     Document Type: Article

References (39)

1. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators: Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 2012;367:20-29.
2. Thurlow JS, Abbott KC, Linberg A, Little D, Fenderson J, Olson SW: SCr and SCysC concentrations before and after traumatic amputation in male soldiers: a case-control study. Am J Kidney Dis 2014;63:167-170.
3. Im EE, Stewart IJ, Morrow BD, Tilley MA, Heegard KD, Aden JK, Chung KK, Cotant CL: Retrospective review of serum creatinine and creatinine-based measures of estimated glomerular filtration rate in an amputee population. Mil Med 2012;177:952-956.
4. Ziegler-Graham K, MacKenzie EJ, Ephraim PL, Travison TG, Brookmeyer R: Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil 2008;89:422-429.
5. Fisher, H: A Guide to US Military Casualty Statistics: Operation Inherent Resolve, Operation New Dawn, Operation Iraqi Freedom, and Operation Enduring Freedom. Congressional Research Service, 2014.
6. Bakalim G: Causes of death in a series of 4738 Finnish war amputees. Artif Limbs 1969;13:27-36.
7. Hrubec Z, Ryder RA: Traumatic limb amputations and subsequent mortality from cardiovascular disease and other causes. J Chronic Dis 1980;33:239-250.
8. Rose HG, Schweitzer P, Charoenkul V, Schwartz E: Cardiovascular disease risk factors in combat veterans after traumatic leg amputations. Arch Phys Med Rehabil 1987;68:20-23.
9. Yekutiel M, Brooks ME, Ohry A, Yarom J, Carel R: The prevalence of hypertension, ischaemic heart disease and diabetes in traumatic spinal cord injured patients and amputees. Paraplegia 1989;27:58-62.
10. Modan M, Peles E, Halkin H, Nitzan H, Azaria M, Gitel S, Dolfin D, Modan B: Increased cardiovascular disease mortality rates in traumatic lower limb amputees. Am J Cardiol 1998;82:1242-1247.
11. Naschitz JE, Lenger R: Why traumatic leg amputees are at increased risk for cardiovascular diseases. QJM 2008;101:251-259.
12. Bolanos JA, Yuan CM, Little DJ, Oliver DK, Howard SR, Abbott KC, Olson SW: Outcomes after post-traumatic AKI requiring RRT in United States military service members. Clin J Am Soc Nephrol 2015;10:1732-1739.
13. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004;351:1296-1305.
14. Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT: Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 2010;375:2073-2081.
15. Woitas RP, Stoffel-Wagner B, Poege U, Schiedermaier P, Spengler U, Sauerbruch T: Low-molecular weight proteins as markers for glomerular filtration rate. Clin Chem 2001;47:2179-2180.
16. Astor BC, Shafi T, Hoogeveen RC, Matsushita K, Ballantyne CM, Inker LA, Coresh J: Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population. Am J Kidney Dis 2012;59:653-662.
17. Tangri N, Inker LA, Tighiouart H, Sorensen E, Menon V, Beck G, Shlipak M, Coresh J, Levey AS, Sarnak MJ: Filtration markers may have prognostic value independent of glomerular filtration rate. J Am Soc Nephrol 2012;23:351-359.
18. Foster MC, Inker LA, Levey AS, Selvin E, Eckfeldt J, Juraschek SP, Coresh J; CKD Biomarkers of all-cause and cardiovascular mortality in US adults. Am J Kidney Dis 2013;62:75-83.
19. Rebholz CM, Grams ME, Matsushita K, Inker LA, Foster MC, Levey AS, Selvin E, Coresh J: Change in multiple filtration markers and subsequent risk of cardiovascular disease and mortality. Clin J Am Soc Nephrol 2015;10:941-948.
20. White CA, Ghazan-Shahi S, Adams MA: β-Trace protein: a marker of GFR and other biological pathways. Am J Kidney Dis 2015;65:131-146.
21. Li W, Mase M, Inui T, Shimoda M, Isomura K, Oda H, Yamada K, Urade Y: Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/beta-trace in canine. Neurosci Res 2008;61:289-293.
22. Hoffmann A, Nimtz M, Conradt HS: Molecular characterization of beta-trace protein in human serum and urine: a potential diagnostic marker for renal diseases. Glycobiology 1997;7:499-506.
23. Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O: Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Proc Natl Acad Sci U S A 1997;94:14689-14694.
24. Osterkamp LK: Current perspective on assessment of human body proportions of relevance to amputees. J Am Diet Assoc 1995;95:215-218.
25. Mozumdar A, Roy SK: Method for estimating body weight in persons with lower-limb amputation and its implication for their nutritional assessment. Am J Clin Nutr 2004;80:868-875.
26. Gallant MA, Samadfam R, Hackett JA, Antoniou J, Parent JL, de Brum-Fernandes AJ: Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. J Bone Miner Res 2005;20:672-681.
27. Gallant MA, Chamoux E, Bisson M, Wolsen C, Parent JL, Roux S, de Brum-Fernandes AJ: Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. J Rheumatol 2010;37:644-649.
28. Stanga Z, Nock S, Medina-Escobar P, Nydegger UE, Risch M, Risch L: Factors other than the glomerular filtration rate that determine the serum beta-2-microglobulin level. PLoS One 2013;8:e72073.
29. Juraschek SP, Coresh J, Inker LA, Levey AS, Köttgen A, Foster MC, Astor BC, Eckfeldt JH, Selvin E: Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population. Clin J Am Soc Nephrol 2013;8:584-592.
30. Magalhães P, Capingana DP, Silva AB, Capunge IR, Gonçalves MA: Arterial stiffness in lower limb amputees. Clin Med Insights Circ Respir Pulm Med 2011;5:49-56.
31. Blicher M, Kruger R, Olesen T, Greve S, Hansen T, Olsen MH: 9A.06: Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects. J Hypertens 2015;33(suppl 1):e118.
32. Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K, Brigham K, Hooper WC, Alexander RW, Jones DP, Quyyumi AA: Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis 2011;218:90-95.
33. Orenes-Piñero E, Manzano-Fernández S, López-Cuenca Á, Marín F, Valdés M, Januzzi JL: β-Trace protein: from GFR marker to cardiovascular risk predictor. Clin J Am Soc Nephrol 2013;8:873-881.
34. Cheung CL, Cheung TT, Lam KS, Cheung BM: Reduced serum beta-trace protein is associated with metabolic syndrome. Atherosclerosis 2013;227:404-407.
35. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F; Centers for Disease Control and Prevention; American Heart Association: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association. Circulation 2003;107:499-511.
36. Albert CM, Ma J, Rifai N, Stampfer MJ, Ridker PM: Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 2002;105:2595-2599.
37. KDIGO CKD Work Group: KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013;3:1-150.
38. Tonelli M, Wanner C; Kidney Disease: Lipid management in chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2013 clinical practice guideline. Ann Intern Med 2014;160:182-189.
39. Juraschek SP, Coresh J, Inker LA, Rynders GP, Eckfeldt JH, Selvin E: The effects of freeze-thaw on β-trace protein and β2-microglobulin assays after long-term sample storage. Clin Biochem 2012;45:694-696.