Molecular characterization of β-trace protein in human serum and urine: A potential diagnostic marker for renal diseases

Glycobiology

Volumn 7, Issue 4, 1997, Pages 499-506

  Hoffmann, Andrea ^a   Nimtz, Manfred ^a   Conradt, Harald S ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

'brain type' N glycosylation; Hepatic clearance; Human trace; Kidney failure; Serum glycoproteins

Indexed keywords

BETA TRACE PROTEIN; LIPOCALIN; PROSTAGLANDIN D SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BLOOD ANALYSIS; CEREBROSPINAL FLUID; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOBLOTTING; KIDNEY DISEASE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN GLYCOSYLATION; PROTEIN ISOLATION; URINALYSIS;

AMINO ACID SEQUENCE; BETA-GLOBULINS; BIOLOGICAL MARKERS; CARBOHYDRATE CONFORMATION; GLYCOSYLATION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; KIDNEY FAILURE, CHRONIC; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; N-ACETYLNEURAMINIC ACID; OLIGOSACCHARIDES; POLYSACCHARIDES; REFERENCE VALUES; RENAL DIALYSIS;

EID: 0030962207     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/7.4.499     Document Type: Article

References (33)

1. Ashwell, G. and Harford, J. (1982) Carbohydrate-specific receptors of the liver. Annu. Rev. Biochem., 51, 531-554.
2. Clausen, J. (1961) Proteins in normal cerebrospinal fluid not found in serum. Proc. Soc. Exp. Biol. Med., 107, 170-172.
3. Cserr, H.F., Harling-Berg, C., Ichimura, T., Knopf, P.M. and Yamada, S. (1990) Drainage of cerebral extracellular fluids into cervical lymph: an afferent limb in brain/ immune system interactions. In Johansson, B.B., Owman, C. and Wicher, H. (eds.), Pathology of the Blood-Brain Barrier. Elsevier, Amsterdam, pp. 234-276.
4. Ericsson, J., Link, H. and Zettervall, O. (1969) Urinary excretion of a low molecular weight protein in cerebral damage. Neurology, 19, 606-610.
5. Felgenhauer, K., Schädlich, H.J. and Nekic, M. (1987) β-Trace protein as marker for cerebrospinal fluid fistula. Klin. Wochensch., 65, 764-768.
6. Hakomori, S. (1964) A rapid permethylation of glycolipid, and polysaccharide catalyzed by methylsulfinyl carbanion in dimethylsulfoxid. J. Biochem. (Tokyo) 55, 205-207.
7. Harrington, M.G., Aebersold, R., Martin, B.M., Merril, C.R. and Hood, L. (1993) Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein. Appl. Theor. Electrophor., 3, 229-234.
8. Hartmann, C., Felgenhauer, K. and Hanssen, C. (1983) Filtration und lokale Synthese von Proteinen im Kammerwasser und Liquor cerebrospinalis. Fortsch. Ophthalmol., 80, 103-107.
9. Hiraoka, A., Miura, I., Hattori, M., Tominaga, I. and Machida, S. (1993) Capillary-zone electrophoretic analyses of the proteins and amino acid components in cerebrospinal fluid of central nervous system diseases. Biol. Pharm. Bull. 16, 949-952.
10. Hochwald, G.M. and Thorbecke, G.J. (1962) Use of an antiserum against cerebrospinal fluid in demonstration of trace proteins in biological fluids. Proc. Soc. Exp. Biol. Med., 109, 91-95.
11. Hoffmann, A., Conradt, H.S., Gross, G., Nimtz, M., Lottspeich, F., Wurster, U. (1993) Purification and chemical characterization of β-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J. Neurochem., 61, 451-456.
12. Hoffmann, A., Nimtz, M., Wurster, U. and Conradt, H.S. (1994) Carbohydrate structures of β-trace protein from human cerebrospinal fluid: evidence for "brain-type" N-glycosylation. J. Neurochem., 63, 2185-2196.
13. Hoffmann, A., Nimtz, M., Getzlaff, R. and Conradt, H.S. (1995) "Brain-type N-glycosylation of asialo-transferrin from human cerebrospinal fluid. FEBS Lett., 359, 164-168.
14. Hoffmann, A., Bächner, D., Betat, N., Lauber, J., and Gross, G. (in press, a) Developmental expression of murine β-trace in embryos and adult animals suggests a function in maturation and maintenance of blood-tissue barriers. Dev. Dynamics.
15. Hoffmann, A., Nimtz, M., Grabenhorst, E. and Conradt, H.S. (in press, b) "Brain-tissue specific" versus "serum-specific" posttranslational modification of human cerebrospinal fluid polypeptides with N-linked carbohydrates. In Couraud, P.O. and Scherman, D. (eds.), Advances in Experimental Medicine and Biology. Plenum Press, New York.
16. Irie, S. and Tavassoli, M. (1991) Transendothelial transport of macromolecules: the concept of tissue-blood barriers. Cell Biol. Rev., 25, 317-331.
17. Kuhn, M., Raida, M., Adermann, K., Schulz-Knappe, P., Gerzer, R., Heim, J.-M., Forssmann, W.-G. (1993) The circulating bioactive form of human guanylin is a high molecular weight peptide (103 kDa). FEBS Lett., 318, 205-209.
18. 4. Nature, 227, 680-685.
19. Link, H. (1967) Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. Chemical and immunological characterization with special reference to multiple sclerosis. Acta Neurol. Scand., 43(Suppl. 28), 1-136.
20. Link, H. and Olsson, J.E. (1972) Beta-trace protein concentration in CSF in neurological disorders. Acta Neurol. Scand., 48, 57-68.
21. Nagata, A., Suzuki, Y., Igarashi, M., Eguchi, N., Toh, H., Urade, Y. and Hayaishi, O. (1991) Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proc. Natl. Acad. Sci. USA, 88, 4020-4024.
22. Nimtz, M., Noll, G., Pâques E.-P., and Conradt, H.S. (1990) Structures of sialylated oligo-saccharides of human EPO expressed in recombinant BHK-21 cells. FEBS Lett., 271, 14-18.
23. Olsson, J.-E. and Link, H. (1973) Distribution of serum proteins and beta trace protein within the nervous system. J. Neurochem., 20, 837-846.
24. 125I-labelled beta-trace protein within the nervous system. J. Neurochem., 21, 1153-1159.
25. Pepe, A.J. and Hochwald, G.M. (1967) Trace proteins in biological fluids. 3. Quantitation of γ-trace and major spinal fluid proteins including β-trace. Proc. Soc. Exp. Med. Biol., 126, 630-633.
26. Poduslo, J.F. and Curran, G.L. (1994) Glycation increases the permeability of proteins across blood-nerve and blood-brain barriers. Mol. Brain Res., 23, 157-162.
27. Schauer, R. (1985) Sialic acids and their role as biological masks. Trends Biol. Sci., 10, 357-360.
28. Segal, M.B. (1993) Extracellular and cerebrospinal fluids. J. Inher. Metab. Dis., 16, 617-638.
29. Thomas, T., Schreiber, G. and Jaworowski, A. (1989) Developmental patterns of gene expression of secreted proteins in brain and choroid plexus. Dev. Biol., 134, 38-47.
30. Thompson, E.J. (1988) The CSF Proteins: A Biochemical Approach. Elsevier, Amsterdam.
31. Urade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N. and Hayaishi, O. (1993) Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proc. Natl. Acad. Sci. USA, 90, 9070-9074.
32. Wiederkehr, F. (1992) Electrophoresis of cerebrospinal fluid proteins. In Chrambach, A., Dunn, M.J. and Radola, B.J. (eds.), Advances in Electrophoresis, Vol. 5. Weinheim, Germany, VCH, p. 241.
33. Zahn, M., Mader, M., Schmidt, E., Bollensen, E. and Felgenhauer, K. (1993) Purification and N-terminal sequence of β-trace, a protein abundant in human cerebrospinal fluid. Neurosci. Lett., 154, 93-95.