Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis?

Chest

Volumn 149, Issue 2, 2016, Pages 508-515

  Hodge, Sandra ^a,h   Upham, John W ^b,c   Pizzutto, Susan ^d   Petsky, Helen L ^e   Yerkovich, Stephanie ^c   Baines, Katherine J ^f   Gibson, Peter ^f   Simpson, Jodie L ^f   Buntain, Helen ^g,i   Chen, Alice C H ^c   Hodge, Greg ^a,h   Chang, Anne B ^d,g,i  

^a HANSON INSTITUTE   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^e QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^f UNIVERSITY OF NEWCASTLE   (Australia)

^g LADY CILENTO CHILDREN S HOSPITAL   (Australia)

^h UNIVERSITY OF ADELAIDE   (Australia)

ⁱ Queensland Children's Medical Research Institute   (Australia)

Author keywords

Bronchiectasis; Childhood lung disease; Inflammation; Macrophage; Phagocytosis; Protracted bacterial bronchitis

Indexed keywords

INTERLEUKIN 1BETA; MANNOSE RECEPTOR;

APOPTOSIS; ARTICLE; BRONCHIECTASIS; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; EFFEROCYTOSIS; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG ALVEOLUS MACROPHAGE; MAJOR CLINICAL STUDY; MALE; NONTYPEABLE HAEMOPHILUS INFLUENZAE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTRACTED BACTERIAL BRONCHITIS; RESPIRATORY TRACT INFLAMMATION; BACTERIAL INFECTION; CELL LINE; CLINICAL TRIAL; COMPLICATION; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; INFANT; METABOLISM; MICROBIOLOGY; MULTICENTER STUDY; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD;

APOPTOSIS; BACTERIAL INFECTIONS; BRONCHIECTASIS; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT; MACROPHAGES, ALVEOLAR; MALE; PHAGOCYTOSIS;

EID: 84958069170     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1016/j.chest.2015.10.066     Document Type: Article

References (43)

1. Chang AB, Grimwood K, Maguire G, King PT, Morris PS, Torzillo PJ. Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities. Med J Aust. 2008;189(7):386-393.
2. Quint JK, Millett E, Hurst JR, Smeeth L, Brown J. Time trends in incidence and prevalence of bronchiectasis in the UK [abstract]. Thorax. 2012;67(suppl 2):A138.
3. O'Grady KA, Torzillo PJ, Chang AB. Hospitalisation of Indigenous children in the Northern Territory for lower respiratory illness in the first year of life. Med J Aust. 2010;192(10):586-590.
4. Kapur N, Masters IB, Chang AB. Longitudinal growth and lung function in pediatric non-cystic fibrosis bronchiectasis: what influences lung function stability? Chest. 2010;138(1): 158-164.
5. Steinfort DP, Brady S, Weisinger HS, Einsiedel L. Bronchiectasis in Central Australia: a young face to an old disease. Respir Med. 2008;102(4):574-578.
6. Singleton RJ, Valery PC, Morris P, et al. Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. Pediatr Pulmonol. 2014;49(2):189-200.
7. Marchant JM, Masters IB, Taylor SM, Cox NC, Seymour GJ, Chang AB. Evaluation and outcome of young children with chronic cough. Chest. 2006;129(5):1132-1141.
8. Chang AB, Landau LI, Van Asperen PP, et al; Thoracic Society of Australia and New Zealand. Cough in children: definitions and clinical evaluation. Med J Aust. 2006;184(8):398-403.
9. Shields MD, Bush A, Everard ML, et al; British Thoracic Society Cough Guideline Group. BTS guidelines: recommendations for the assessment and management of cough inchildren. Thorax. 2008;63(suppl 3): iii1-iii15.
10. van der Gast CJ, Cuthbertson L, Rogers GB, et al. Three clinically distinct chronic pediatric airway infections share a common core microbiota. Ann Am Thorac Soc. 2014;11(7):1039-1048.
11. Chang AB, Byrnes CA, Everard ML. Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis. Paediatr Respir Rev. 2011;12(2):97-103.
12. Hodge S, Hodge G, Holmes M, Reynolds PN. Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J. 2005;25(3):447-454.
13. Trautmann A, Schmid-Grendelmeier P, Krüger K, et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma. J Allergy Clin Immunol. 2002;109(2):329-337.
14. Cohen-Cymberknoh M, Kerem E, Ferkol T, Elizur A. Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications. Thorax. 2013;68(12):1157-1162.
15. Hodge S, Hodge G, Scicchitano R, Reynolds PN, Holmes M. Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol. 2003;81(4):289-296.
16. Hodge S, Dean M, Hodge G, Holmes M, Reynolds PN. Decreased efferocytosis and mannose binding lectin in the airway in bronchitis obliterans syndrome. J Heart Lung Transplant. 2011;30(5):589-595.
17. Hodge S, Hodge G, Jersmann H, et al. Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178(2):139-148.
18. Simpson JL, Gibson PG, Yang IA, et al; AMAZES Study Research Group. Impaired macrophage phagocytosis in non-eosinophilic asthma. Clin Exp Allergy. 2013;43(1):29-35.
19. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest. 2006;129(6):1673-1682.
20. Voglis S, Quinn K, Tullis E, et al. Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. Am J Respir Crit Care Med. 2009;180(2):159-166.
21. Hodge S, Matthews G, Mukaro V, et al. Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine. Am J Respir Cell Mol Biol. 2011;44(5):673-681.
22. Hodge S, Matthews G, Dean MM, et al. Therapeutic role for mannose-binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model. Am J Respir Cell Mol Biol. 2010;42(2):235-242.
23. Hare KM, Grimwood K, Leach AJ, et al. Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis. J Pediatr. 2010;157(6): 1001-1005.
24. Hare KM, Binks MJ, Grimwood K, Chang AB, Leach AJ, Smith-Vaughan H. Culture and PCR detection of Haemophilus influenzae and Haemophilus haemolyticus in Australian Indigenous children with bronchiectasis. J Clin Microbiol. 2012;50(7):2444-2445.
25. Baines KJ, Upham JW, Yerkovich ST, et al. Mediators of neutrophil function in children with protracted bacterial bronchitis. Chest. 2014;146(4):1013-1020.
26. Chang AB, Bell SC, Byrnes CA, et al. Bronchiectasis and chronic suppurative lung disease (CSLD) in children and adults in Australian and New Zealand. Med J Aust. 2010;193(6):356-365.
27. Wurzel D, Marchant JM, Yerkovich ST, et al. Prospective characterization of protracted bacterial bronchitis in children. Chest. 2014;145(6):1271-1278.
28. Kapur N, Masel JP, Watson D, Masters IB, Chang AB. Bronchoarterial ratio on high resolution CT scan of the chest in children without pulmonary pathology: need to redefine bronchial dilatation. Chest. 2011;139(6):1445-1450.
29. Tran HB, Ahern J, Hodge G, et al. Oxidative stress decreases functional airway mannose binding lectin in COPD. PLoS One. 2014;9(6):e98571.
30. Cozens AL, Yezzi MJ, Kunzelmann K, et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol. 1994;10(1):38-47.
31. Chang AB, Robertson CF, Van Asperen PP, et al. A multicenter study on chronic cough in children: burden and etiologies based on a standardized management pathway. Chest. 2012;142(4):943-950.
32. Tennant PW, Gibson GJ, Parker L, Pearce MS. Childhood respiratory illness and lung function at ages 14 and 50 years: childhood respiratory illness and lung function. Chest. 2010;137:146-155.
33. Maritz G, Probyn M, De Matteo R, Snibson K, Harding R. Lung parenchyma at maturity is influenced by postnatal growth but not by moderate preterm birth in sheep. Neonatology. 2008;93(1):28-35.
34. Hodge S, Reynolds PN. Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocytederived macrophages in chronic obstructive pulmonary disease subjects. Respirology. 2012;17(5):802-807.
35. Pizzutto SH, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang AB. Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable. Haemophilus influenzae. PLoS One. 2014;9(8):e104236.
36. Bozinovski S, Vlahos R, Zhang Y, et al. Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity. Am J Respir Cell Mol Biol. 2011;45(2): 229-236.
37. Richens TR, Linderman DJ, Horstmann SA, et al. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009;179(11):1011-1021.
38. Fitzpatrick AM, Holguin F, Teague WG, Brown LA. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol. 2008;121(6):1372-1378, 1378.e1-1378.e3.
39. Jayaraman P, Sada-Ovalle I, Nishimura T, et al. IL-1b promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013;190(8): 4196-4204.
40. Vlahos R, Bozinovski S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol. 2014;5:435.
41. Valery PC, Morris PS, Byrnes CA, et al. Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2013;1(8):610-620.
42. Goyal V, Grimwood K, Marchant JM, Masters IB, Chang AB. Does failed chronic wet cough response to antibiotics predict bronchiectasis? Arch Dis Child. 2014;99(6):522-525.
43. Pearce MS, Salotti JA, Little MP, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012;380(9840): 499-505.