Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Nature Communications

Volumn 7, Issue , 2016, Pages

  Berrios, Janet ^a,b   Stamatakis, Alice M ^a,b,c   Kantak, Pranish A ^b   McElligott, Zoe A ^b   Judson, Matthew C ^b   Aita, Megumi ^b   Rougie, Marie ^b   Stuber, Garret D ^a,b   Philpot, Benjamin D ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Inscopix   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; RESERPINE; TYROSINE 3 MONOOXYGENASE; UBIQUITIN PROTEIN LIGASE E3; VESICULAR INHIBITORY AMINO ACID TRANSPORTER; DOPAMINE; UBE3A PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

AMINO ACID; INHIBITOR; NEUROLOGY; PROTEIN;

4 AMINOBUTYRIC ACID RELEASE; 4 AMINOBUTYRIC ACID UPTAKE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DOPAMINE RELEASE; HAPPY PUPPET SYNDROME; IN VITRO STUDY; MEMBRANE STEADY POTENTIAL; MOTIVATION; MOUSE; NERVE CELL; NERVE ENDING; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN DEPLETION; PROTEIN EXPRESSION; REINFORCEMENT; REWARD; SELF STIMULATION; VENTRAL TEGMENTUM; VISUAL STIMULATION; ANIMAL; C57BL MOUSE; CYTOLOGY; DOPAMINERGIC NERVE CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; NERVE TRACT; OPTOGENETICS; PATCH CLAMP TECHNIQUE; SECRETION (PROCESS); STEREOTACTIC PROCEDURE; SYNAPTIC TRANSMISSION;

ANIMALS; BEHAVIOR, ANIMAL; DOPAMINE; DOPAMINERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTIVATION; NEURAL PATHWAYS; NEURONS; NUCLEUS ACCUMBENS; OPTOGENETICS; PATCH-CLAMP TECHNIQUES; REINFORCEMENT (PSYCHOLOGY); REWARD; SELF STIMULATION; STEREOTAXIC TECHNIQUES; SYNAPTIC TRANSMISSION; TYROSINE 3-MONOOXYGENASE; UBIQUITIN-PROTEIN LIGASES; VENTRAL TEGMENTAL AREA;

EID: 84957990534     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10702     Document Type: Article

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