Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons

Science

Volumn 350, Issue 6256, 2015, Pages 102-106

  Kim, Jae Ick ^a   Ganesan, Subhashree ^a   Luo, Sarah X ^b,c   Wu, Yu Wei ^a   Park, Esther ^a   Huang, Eric J ^b,c,d   Chen, Lu ^a   Ding, Jun B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENASE; CARBOXYLYASE; GLUTAMATE DECARBOXYLASE 65; GLUTAMIC ACID; NEUROTRANSMITTER; ALDH1A1 PROTEIN, MOUSE;

ALCOHOL; ALDEHYDE; BRAIN; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; FOOD CONSUMPTION; GENE EXPRESSION; NEUROLOGY; PROTEIN;

ADDICTION; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; AMINO ACID SYNTHESIS; ARTICLE; BINGE DRINKING; CONCENTRATION (PARAMETERS); DOPAMINERGIC NERVE CELL; GENE DELETION; MESENCEPHALON; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REWARD; ANIMAL; BIOSYNTHESIS; BLOOD; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE SILENCING; GENETICS; MALE; METABOLISM; MOLECULAR EVOLUTION; MOUSE;

ALDEHYDE DEHYDROGENASE; ANIMALS; BINGE DRINKING; DOPAMINERGIC NEURONS; ETHANOL; EVOLUTION, MOLECULAR; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENE KNOCKDOWN TECHNIQUES; MALE; MESENCEPHALON; METABOLIC NETWORKS AND PATHWAYS; MICE; REWARD; SEQUENCE DELETION;

EID: 84943784472     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac4690     Document Type: Article

References (40)

1. W. Schultz, Annu. Rev. Neurosci. 30, 259-288 (2007).
2. N. X. Tritsch, B. L. Sabatini, Neuron 76, 33-50 (2012).
3. B. T. Chen, F. W. Hopf, A. Bonci, Ann. N. Y. Acad. Sci. 1187, 129-139 (2010).
4. P. Redgrave et al., Nat. Rev. Neurosci. 11, 760-772 (2010).
5. N. X. Tritsch, J. B. Ding, B. L. Sabatini, Nature 490, 262-266 (2012).
6. T. González-Hernández, P. Barroso-Chinea, A. Acevedo, E. Salido, M. Rodríguez, Eur. J. Neurosci. 13, 57-67 (2001).
7. N. X. Tritsch, W. J. Oh, C. Gu, B. L. Sabatini, eLife 3, e01936 (2014).
8. W. Matsuda et al., J. Neurosci. 29, 444-453 (2009).
9. C. L. Heusner, L. R. Beutler, C. R. Houser, R. D. Palmiter, Genesis 46, 357-367 (2008).
10. S. Lammel et al., Neuron 85, 429-438 (2015).
11. P. Hoerbelt, T. A. Lindsley, M. W. Fleck, J. Neurosci. 35, 3525-3536 (2015).
12. K. Williams, Cell. Signal. 9, 1-13 (1997).
13. S. G. Xing, Y. B. Jun, Z. W. Hau, L. Y. Liang, Plant Physiol. Biochem. 45, 560-566 (2007).
14. B. J. Shelp et al., Plant Sci. 193-194, 130-135 (2012).
15. M. R. Bell, J. A. Belarde, H. F. Johnson, C. D. Aizenman, Nat. Neurosci. 14, 505-512 (2011).
16. E. B. Sequerra, P. Gardino, C. Hedin-Pereira, F. G. de Mello, Neuroscience 146, 489-493 (2007).
17. T. Noto et al., Pharmacol. Biochem. Behav. 25, 411-414 (1986).
18. E. N. Yamasaki, V. D. Barbosa, F. G. De Mello, J. N. Hokoc, Int. J. Dev. Neurosci. 17, 201-213 (1999).
19. J. Laschet, T. Grisar, M. Bureau, D. Guillaume, Neuroscience 48, 151-157 (1992).
20. B. A. Barres, W. J. Koroshetz, K. J. Swartz, L. L. Chun, D. P. Corey, Neuron 4, 507-524 (1990).
21. J. Aoto, C. I. Nam, M. M. Poon, P. Ting, L. Chen, Neuron 60, 308-320 (2008).
22. G. Liu et al., J. Clin. Invest. 124, 3032-3046 (2014).
23. P. McCaffery, U. C. Dräger, Proc. Natl. Acad. Sci. U.S.A. 91, 7772-7776 (1994).
24. Allen Brain Atlas, http://mouse.brain-map.org/gene/show/11455.
25. V. Vasiliou, A. Pappa, D. R. Petersen, Chem. Biol. Interact. 129, 1-19 (2000).
26. D. S. Goldstein et al., J. Neurochem. 126, 591-603 (2013).
27. X. Fan et al., Mol. Cell. Biol. 23, 4637-4648 (2003).
28. R. Sherva et al., Alcohol. Clin. Exp. Res. 33, 848-857 (2009).
29. J. Liu et al., Alcohol. Clin. Exp. Res. 35, 304-316 (2011).
30. B. J. Everitt, T. W. Robbins, Nat. Neurosci. 8, 1481-1489 (2005).
31. G. Chen et al., Alcohol. Clin. Exp. Res. 35, 1739-1748 (2011).
32. J. Wang et al., J. Neurosci. 32, 15124-15132 (2012).
33. L. E. O'Dell, A. J. Roberts, R. T. Smith, G. F. Koob, Alcohol. Clin. Exp. Res. 28, 1676-1682 (2004).
34. S. Ben Hamida et al., J. Neurosci. 33, 14369-14378 (2013).
35. T. S. Hnasko et al., Neuron 65, 643-656 (2010).
36. D. H. Root et al., Nat. Neurosci. 17, 1543-1551 (2014).
37. S. J. Shabel, C. D. Proulx, J. Piriz, R. Malinow, Science 345, 1494-1498 (2014).
38. D. M. Lovinger, Neuropharmacology 58, 951-961 (2010).
39. C. M. Pennartz et al., J. Neurosci. 29, 12831-12838 (2009).
40. J. L. Weiner, C. F. Valenzuela, Pharmacol. Ther. 111, 533-554 (2006).