Anti-carbamylated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients: Lack of correlation with anti-cyclic citrullinated protein antibodies and rheumatoid factor

Clinical and Experimental Rheumatology

Volumn 33, Issue 6, 2015, Pages 824-830

  Alessandri, Cristiano ^a   Bartosiewicz, Izabella ^a   Pendolino, Monica ^a   Mancini, Riccardo ^a   Colasanti, Tania ^a   Pecani, Arbi ^a   Morello, Francesca ^a   Mastrangelo, Andrea ^a   Sabatinelli, Danilo ^a   Riccieri, Valeria ^a   Di Franco, Manuela ^a   Ceccarelli, Fulvia ^a   Perricone, Carlo ^a   Conti, Fabrizio ^a   Valesini, Guido ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Anti CarP; Anti CCP; HFDRs; Rheumatoid arthritis; Rheumatoid factor

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CARBAMIC ACID DERIVATIVE; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; RHEUMATOID FACTOR;

ADULT; ARTHRITIS, RHEUMATOID; BLOOD; FAMILY; FAMILY HEALTH; FEMALE; HUMAN; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; MALE; PROCEDURES; STATISTICS;

ADULT; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; CARBAMATES; FAMILY; FAMILY HEALTH; FEMALE; HUMANS; IMMUNOLOGIC TESTS; MALE; PEPTIDES, CYCLIC; RHEUMATOID FACTOR; STATISTICS AS TOPIC;

EID: 84957974736     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. ALETAHA D, NEOGI T, SILMAN AJ et al: 2010 Rheumatoid Arthritis Classification Criteria. Arthritis Rheum 2010; 9: 2569-81.
2. NEWKIRK MM: Rheumatoid factors: host resistance or autoimmunity? Clin Immunol 2002; 104: 1-13.
3. NISHIMURA K, SUGIYAMA D, KOGATA Y et al.: Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007; 146: 797-808.
4. ATÉ A, KARAASLAN Y, AKSARAY S: Predictive value of antibodies to cyclic citrullinated peptide in patients with early arthritis. Clin Rheumatology 2007; 26: 499-504.
5. NIELEN MM, VAN SCHAARDENBURG D, REESINK HW et al.: Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380-6.
6. SHI J, KNEVEL R, SUWANNALAI P, VAN DER LINDEN MP et al.: Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA 2011; 42: 17372-7.
7. WANG Z, NICHOLLS SJ, RODRIGUEZ ER et al.: Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 2007; 10: 1176-84.
8. MYDEL P, WANG Z, BRISSLERT M et al.: Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. J Immunol 2010; 12: 6882-90.
9. TURUNEN S, KOIVULA MK, RISTELI L, RISTELI J: Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits. Arthritis Rheum 2010; 62: 3345-52.
10. SHI J, VAN DE STADT LA, LEVARHT EW et al.: Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis. Arthritis Rheum 2013; 4: 911-5.
11. RANTAPÄÄ-DAHLQVIST S, DE JONG BA, BERGLIN E et al.: Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003; 48: 2741-9.
12. LAZARIDIS KN, JURAN BD, BOE GM et al.: Increased prevalence of antimitochondrial antibodies in first degree relatives of patients with primary biliary cirrosis. Hepatology 2007; 46: 785-92.
13. CLELAND LG, BELL DA, WILLIAMS M, SAURINO BC: Familial Lupus. Family studies of HLA and serologic findings. Arthritis Rheum 1978; 21: 183-91.
14. ARNETT FC, HAMILTON RG, REVEILLET JD, BIAS WB, HARLEY JB, REICHLIN M: Genetic studies of Ro (SS-A) and La (SS-B) autoantibodies in families with systemic lupus erythematosus and primary Sjögren's syndrome. Arthritis Rheum 1989; 32: 413-9.
15. SILMAN AJ, OTHER B, MAGEED RA: Rheumatoid factor detection in the unaffected first degree relatives in families with multicase rheumatoid arthritis. J Rheumatol 1991; 18: 512-5.
16. BARRA L, SCINOCCA M, SAUNDERS S et al.: Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients. Arthritis Rheum 2013; 6: 1439-47.
17. YOUNG KA, DEANE KD, DERBER LA, HUGHES-AUSTIN JM, WAGNER CA, SOKOLOVE J: Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies which are associated with arthritis-related traits: Studies of the etiology of rheumatoid arthritis. Arthritis Rheum 2013; 8: 1995-2004.
18. VAN STEENBERGEN HW, HUIZINGA TW, VAN DER HELM-VAN MIL AH: Review: The preclinical phase of rheumatoid arthritis: what is acknowledged and what needs to be assessed? Arthritis Rheum 2013; 9: 2219-32.
19. KIM SK, BAE J, LEE H, KIM JH, PARK SH, CHOE JY: Greater prevalence of seropositivity for anti-cyclic citrullinated peptide antibody in unaffected first-degree relatives in multicase rheumatoid arthritis-affected families. Korean J Intern Med 2013; 1: 45-53.
20. IOAN-FACSINAY A, WILLEMZE A, ROBINSON DB et al.: Marked differences in fine specificity and isotype usage of the anticitrullinated protein antibody in health and disease. Arthritis Rheum 2008; 58: 3000-8.
21. GOELDNER I, SKARE TL, DE MESSIAS REASON IT, NISIHARA RM, SILVA MB, UTIYAMA SR: Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil. Rheumatology 2010; 49: 1590-3.
22. LEE AN, BECK CE, HALL M: Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review. Clin Lab Sci 2008; 21: 15-8.
23. BALSA A, CABEZÖN A, OROZCO G et al.: Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res Ther 2010; 12: R62.
24. CHARPIN C, MARTIN M, BALANDRAUD N, ROUDIER J, AUGER I: Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis. Arthritis Res Ther 2010; 12: R194.
25. FERUCCI ED, DARRAH E, SMOLIK I et al.: Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations. J Rheumatol 2013; 40: 1523-8.
26. SHI J, VAN DE STADT LA, LEVARHT EW et al: Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis 2014; 73: 780-3.
27. SCINOCCA M, BELL DA, RACAPE M et al.: Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides. J Rheumatol 2014: 41: 270-9.
28. SHI J, WILLEMZE A, JANSSEN GM et al.: Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the "AMC-Senshu" method. Ann Rheum Dis 2013; 72: 148-50.
29. VAN DER HELM-VAN MIL AH, VERPOORT KN, LE CESSIE S, HUIZINGA TW, DE VRIES RR, TOES RE: The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum 2007; 56: 425-32.
30. ROBERTS JM, VERES PR, COCHRAN AK et al.: Isocyanic acid in the atmosphere and its possible link to smoke-related health effects. Proc Natl Acad Sci USA 2011; 108: 8966-71.