Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits

Arthritis and Rheumatism

Volumn 62, Issue 11, 2010, Pages 3345-3352

  Turunen, Sanna ^a   Koivula, Marja Kaisa ^a   Risteli, Leila ^a   Risteli, Juha ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CITRULLINE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; CYANIC ACID; CYCLIC CITRULLINATED PEPTIDE 2 ANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HOMOCITRULLINE; HUMAN ALBUMIN; TELOPEPTIDE; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CARBAMOYLATION; CONTROLLED STUDY; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RABBIT; RHEUMATOID ARTHRITIS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRULLINE; MALE; RABBITS;

EID: 78249272045     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27644     Document Type: Article

References (16)

1. Schellekens GA, de Jong BA, van den Hoogen FH, van den Putte LB, van Venrooij WJ,. Citrulline is an essential constituent of antigenic determinants recognised by rheumatoid arthritis specific autoantibodies. J Clin Invest 1998; 101: 273 - 81.
2. Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon B, Sebbag M, Vincent C, et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol 1999; 162: 585 - 94.
3. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380 - 6.
4. Koivula MK, Heliovaara M, Ramberg J, Knekt P, Rissanen H, Palosuo T, et al. Autoantibodies binding to citrullinated telopeptide of type II collagen and to cyclic citrullinated peptides predict synergistically the development of seropositive rheumatoid arthritis. Ann Rheum Dis 2007: 66: 1450 - 55.
5. Tarcsa E, Marekov LN, Mei G, Melino G, Lee SC, Steinert PM,. Protein unfolding by peptidylarginine deiminase: substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin. J Biol Chem 1996; 271: 30709 - 16.
6. Gyorgy B, Toth E, Tarcsa E, Falus A, Buzas EI,. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol 2006; 38: 1662 - 77.
7. Wang Z, Nicholls SJ, Rene Rodriguez E, Kummu O, Horkko S, Barnard J, et al. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 2007; 13: 1176 - 84.
8. Senshu T, Akiyama K, Kan S, Asaga H, Ishigami A, Manabe M,. Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues. J Invest Dermatol 1995; 105: 163 - 9.
9. Senshu T, Sato T, Inoue T, Akiyama K, Asaga H,. Detection of citrulline residues in deiminated proteins on polyvinylidene difluoride membrane. Anal Biochem 1992; 203: 94 - 100.
10. Jaisson S, Delavallee-Forte C, Toure F, Rieu P, Garnotel R, Gillery P,. Carbamylated albumin is a potent inhibitor of polymorphonuclear neurophil respiratory burst. FEBS Letters 2007; 581: 1509 - 13.
11. Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L,. Radioimmunoassay for the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem 1993; 39: 635 - 40.
12. Holm A, Rise F, Sessler N, Sollid LM, Undheim K, Flechenstein B,. Specific modifications of peptide-bound citrulline residues. Anal Biochem 2006; 352: 68 - 76.
13. Koivula MK, Aman S, Alasaarela E, Karjalainen A, Hakala M, Risteli J,. Inhibitory characteristics of citrullinated telopeptides of type I and II collagens for autoantibody binding in patients with rheumatoid arthritis. Rheumatology (Oxford) 2006; 45: 1364 - 9.
14. Matsuo K, Xiang Y, Nakamura H, Masuko K, Yudoh K, Noyori K, et al. Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther 2006; 8: R175 - 88.
15. Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, et al, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006; 54: 38 - 46.
16. Klareskog L, Ronnelid J, Lundberg K, Padyukov L, Alfredsson L,. Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008; 26: 651 - 75.