Insulin requires A1 adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium

Purinergic Signalling

Volumn 12, Issue 1, 2016, Pages 175-190

  Guzmán Gutiérrez, Enrique ^a,b   Armella, Axel ^b   Toledo, Fernando ^c   Pardo, Fabián ^a   Leiva, Andrea ^a   Sobrevia, Luis ^a,d,e  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD SAN SEBASTIÁN   (Chile)

^c UNIVERSIDAD DEL BÍO BÍO   (Chile)

^d UNIVERSITY OF SEVILLE   (Spain)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Adenosine receptor; Diabetes; Endothelium; Fetal; Insulin

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; AMINO ACID TRANSPORTER; ARGININE; INSULIN; ANTIDIABETIC AGENT; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; SLC7A1 PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; PREGNANCY DIABETES MELLITUS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLC7A1 GENE; WESTERN BLOTTING; ADOLESCENT; BIOSYNTHESIS; DIABETES, GESTATIONAL; DIET THERAPY; DRUG EFFECTS; GENETICS; MALE; METABOLISM; NEWBORN; PREGNANCY; PRIMARY CELL CULTURE; UMBILICAL VEIN; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; YOUNG ADULT;

ADOLESCENT; ADULT; ARGININE; CATIONIC AMINO ACID TRANSPORTER 1; DIABETES, GESTATIONAL; ENDOTHELIUM, VASCULAR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INFANT, NEWBORN; INSULIN; MALE; PREGNANCY; PRIMARY CELL CULTURE; RECEPTOR, ADENOSINE A1; UMBILICAL VEINS; YOUNG ADULT;

EID: 84957967496     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-015-9491-2     Document Type: Article

References (31)

1. Metzger BE, Buchanan TA, Coustan DR, de Leiva A, Dunger DB, Hadden DR, Hod M, Kitzmiller JL, Kjos SL, Oats JN, Pettitt DJ, Sacks DA, Zoupas C (2007) Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 30:251–260
2. Colomiere M, Permezel M, Riley C, Desoye G, Lappas M (2009) Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. Eur J Endocrinol 160:567–578
3. Sobrevia L, Salsoso R, Sáez T, Sanhueza C, Pardo F, Leiva A (2015) Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus. Exp Physiol 100:231–238
4. Vásquez G, Sanhueza F, Vásquez R, González M, San Martín R, Casanello P, Sobrevia L (2004) Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 560:111–122
5. Calabrò RS, Gervasi G, Bramanti P (2014) L-Arginine and vascular diseases: lights and pitfalls! Acta Biomed 85:222–228
6. Guzmán-Gutiérrez E, Westermeier F, Salomón C, González M, Pardo F, Leiva A, Sobrevia L (2012) Insulin-increased L-arginine transport requires A2A adenosine receptors activation in human umbilical vein endothelium. PLoS One 7:e41705
7. Read MA, Boura AL, Walters WA (1993) Vascular actions of purines in the foetal circulation of the human placenta. Br J Pharmacol 110:454–460
8. Westermeier F, Salomón C, Farías M, Arroyo P, Fuenzalida B, Sáez T, Salsoso R, Sanhueza C, Guzmán-Gutiérrez E, Pardo F, Leiva A, Sobrevia L (2015) Insulin requires normal expression and signalling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium. FASEB J 29:37–49
9. Eltzschig HK (2009) Adenosine: an old drug newly discovered. Anesthesiology 111:904–915
10. Fredholm BB (2014) Adenosine—a physiological or pathophysiological agent? J Mol Med (Berl) 92:201–206
11. Antonioli L, Blandizzi C, Csóka B, Pacher P, Haskó G (2015) Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations. Nat Rev Endocrinol 11:228–241
12. Westermeier F, Salomón C, González M, Puebla C, Guzmán-Gutiérrez E, Cifuentes F, Leiva A, Casanello P, Sobrevia L (2011) Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium. Diabetes 60:1677–1687
13. Maguire MH, Szabó I, Valkó IE, Finley BE, Bennett TL (1998) Simultaneous measurement of adenosine and hypoxanthine in human umbilical cord plasma using reversed-phase high-performance liquid chromatography with photodiode-array detection and on-line validation of peak purity. J Chromatogr B Biomed Sci Appl 707:33–41
14. Devés R, Boyd CA (1998) Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev 78:487–545
15. Mann GE, Yudilevich DL, Sobrevia L (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83:183–252
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
17. Wang YH, Wu HH, Ding H, Li Y, Wang ZH, Li F, Zhang JP (2013) Changes of insulin resistance and β-cell function in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnant period: a case–control study. J Obstet Gynaecol Res 39:647–652
18. González M, Gallardo V, Rodríguez N, Salomón C, Westermeier F, Guzmán-Gutiérrez E, Abarzúa F, Leiva A, Casanello P, Sobrevia L (2011) Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation. J Cell Physiol 262:2916–2924
19. Chin-Dusting JP, Willems L, Kaye DM (2007) L-arginine transporters in cardiovascular disease: a novel therapeutic target. Pharmacol Ther 116:428–436
20. Rajapakse NW, Johnston T, Kiriazis H, Chin-Dusting J, Du XJ, Kaye DM (2015) Augmented endothelial L-arginine transport ameliorates pressure overload induced cardiac hypertrophy. Exp Physiol. doi:10.1113/EP085250
21. Closs EI, Scheld JS, Sharafi M, Förstermann U (2000) Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol 57:68–74
22. Salomón C, Westermeier F, Puebla C, Arroyo P, Guzmán-Gutiérrez E, Pardo F, Leiva A, Casanello P, Sobrevia L (2012) Gestational diabetes reduces adenosine transport in human placental microvascular endothelium, an effect reversed by insulin. PLoS One 7:e40578
23. Simmons WW, Closs EI, Cunningham JM, Smith TW, Kelly RA (1996) Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes. Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B. J Biol Chem 271:11694–11702
24. Ethier MF, Chander V, Dobson JG Jr (1993) Adenosine stimulates proliferation of human endothelial cells in culture. Am J Physiol 265:H131–H138
25. Yoneyama Y, Suzuki S, Sawa R, Yoneyama K, Power GG, Araki T (2002) Increased plasma adenosine concentrations and the severity of preeclampsia. Obstet Gynecol 100:1266–1270
26. Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE (2011) International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update. Pharmacol Rev 63:1–34
27. Huang CC, Chiribau CB, Majumder M, Chiang CM, Wek RC, Kelm RJ Jr, Khalili K, Snider MD, Hatzoglou M (2009) A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). J Biol Chem 284:32312–32320
28. Wang Q, Huang R, Yu B, Cao F, Wang H, Zhang M, Wang X, Zhang B, Zhou H, Zhu Z (2013) Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. PLoS One 8:e59845
29. Norman RJ, Wang JX, Hague W (2004) Should we continue or stop insulin sensitizing drugs during pregnancy? Curr Opin Obstet Gynecol 16:245–250
30. Verier-Mine O (2010) Outcomes in women with a history of gestational diabetes. Screening and prevention of type 2 diabetes. Literature review. Diabetes Metab 36:595–616
31. Löbner K, Knopff A, Baumgarten A, Mollenhauer U, Marienfeld S, Garrido-Franco M, Bonifacio E, Ziegler AG (2006) Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes 55:792–797