Elevated plasma levels of glutamate in children with autism spectrum disorders

NeuroReport

Volumn 27, Issue 4, 2016, Pages 272-276

  Caia, Jing ^a   Ding, Li ^a   Zhang, Jin Shan ^a   Xue, Jie ^b   Wang, Ling Zhang ^c  

^a Department of Neurosurgery ^*  (China)

^b LINYI CANCER HOSPITAL   (China)

^c LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

Autism spectrum disorders; Diagnosis; Glutamate; Glutamate receptors

Indexed keywords

C REACTIVE PROTEIN; GLUTAMIC ACID; HOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ARTICLE; AUTISM; AUTISM ASSESSMENT; CHILD; CHILDHOOD AUTISM RATING SCALE SCORE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; INTELLECTUAL IMPAIRMENT; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; AREA UNDER THE CURVE; BLOOD; BLOOD ANALYSIS; MULTIVARIATE ANALYSIS; PRESCHOOL CHILD; PSYCHOLOGICAL RATING SCALE; RECEIVER OPERATING CHARACTERISTIC; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

AREA UNDER CURVE; AUTISM SPECTRUM DISORDER; BLOOD CHEMICAL ANALYSIS; CHILD, PRESCHOOL; CHROMATOGRAPHY, LIQUID; FEMALE; GLUTAMIC ACID; HUMANS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; PSYCHIATRIC STATUS RATING SCALES; ROC CURVE; SEVERITY OF ILLNESS INDEX; TANDEM MASS SPECTROMETRY;

EID: 84957945238     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000532     Document Type: Article

References (28)

1. Yang P, Chang CL. Glutamate-mediated signaling and autism spectrum disorders: emerging treatment targets. Curr Pharm Des 2014;20:5186-5193.
2. Taurines R, Segura M, Schecklmann M, Albantakis L, Grünblatt E, Walitza S, et al. Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. J Neural Transm (Vienna) 2014;121:1117-1128.
3. Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003;33:365-382.
4. Gong ZL, Luo CM, Wang L, Shen L, Wei F, Tong RJ, Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport 2014;25:23-27.
5. Fombonne E. Epidemiological trends in rates of autism. Mol Psychiatry 2002;7(Suppl 2):S4-S6.
6. Ratajczak HV. Theoretical aspects of autism: biomarkers - a review. J Immunotoxicol 2011;8:80-94.
7. Bashir S, Laila ALA. Role of serum levels of neurotensin in children with autism spectrum disorder. Neurol Psychiatry Brain Res 2013;19:59-63.
8. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol 2011;232:196-199.
9. Choudhury PR, Lahiri S, Rajamma U. Glutamate mediated signaling in the pathophysiology of autism spectrum disorders. Pharmacol Biochem Behav 2012;100:841-849.
10. Carlsson ML. Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate-serotonin interactions for pharmacotherapy. J Neural Transm 1998;105:525-535.
11. Alfredsson G, Wiesel FA, Tylec A. Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers. Biol Psychiatry 1988;23:689-697.
12. APA. Diagnostic and Statistical Manual of Mental Disorders. Arlington, VA: American Psychiatric Publishing Inc.; 2000.
13. Chlebowski C, Green JA, Barton ML, Fein D. Using the childhood autism rating scale to diagnose autism spectrum disorders. J Autism Dev Disord 2010;40:787-799.
14. Moreno-Fuenmayor H, Borjas L, Arrieta A, Valera V, Socorro-Candanoza L. Plasma excitatory amino acids in autism. Invest Clin 1996;37:113-128.
15. Aldred S, Moore KM, Fitzgerald M, Waring RH. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord 2003;33:93-97.
16. Shimmura C, Suda S, Tsuchiya KJ, Hashimoto K, Ohno K, Matsuzaki H, et al. Alteration of plasma glutamate and glutamine levels in children with highfunctioning autism. PLoS One 2011;6:e25340.
17. Shinohe A, Hashimoto K, Nakamura K, Tsujii M, Iwata Y, Tsuchiya KJ, et al. Increased serum levels of glutamate in adult patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1472-1477.
18. Hassan TH, Abdelrahman HM, Fattah NRA, El-Masry NM, Hashim HM, El-Gerby KM, Abdel Fattah NR. Blood and brain glutamate levels in children with autistic disorder. Res Autism Spectr Discord 2013;7:541-548.
19. Tebartz van Elst L, Maier S, Fangmeier T, Endres D, Mueller GT, Nickel K, et al. Disturbed cingulate glutamate metabolism in adults with highfunctioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis. Mol Psychiatry 2014;19:1314-1325.
20. Page LA, Daly E, Schmitz N, Simmons A, Toal F, Deeley Q, et al. In vivo 1Hmagnetic resonance spectroscopy study of amygdalahippocampal and parietal regions in autism. Am J Psychiatry 2006;163:2189-2192.
21. Joshi G, Biederman J, Wozniak J, Goldin RL, Crowley D, Furtak S, et al. Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T. Eur Arch Psychiatry Clin Neurosci 2013;263:379-384.
22. D'Antoni S, Spatuzza M, Bonaccorso CM, Musumeci SA, Ciranna L, Nicoletti F, et al. Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neurosci Biobehav Rev 2014;46(Pt 2):228-241.
23. Fatemi SH, Folsom TD, Kneeland RE, Yousefi MK, Liesch SB, Thuras PD, et al. Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatalenriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex. Mol Autism 2013;4:1-19.
24. Blaylock RL, Strunecka A. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem 2009;16:157-170.
25. Debanne D, Daoudal G, Sourdet V, Russier M. Brain plasticity and ion channels. J Physiol Paris 2003;97:403-414.
26. Manent JB, Represa A. Neurotransmitters and brain maturation: early paracrine actions of GABA and glutamate modulate neuronal migration. Neuroscientist 2007;13:268-279.
27. Hoehn-Saric R, McLeod DR, Glowa JR. The effects of NMDA receptor blockade on the acquisition of a conditioned emotional response. Biol Psychiatry 1991;30:170-176.
28. Belsito KM, Law PA, Kirk KS, Landa RJ, Zimmerman AW. Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebocontrolled trial. J Autism Dev Disord 2001;31:175-181.