Molecule targeting glucosyltransferase inhibits Streptococcus mutans biofilm formation and virulence

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 1, 2016, Pages 126-135

  Ren, Zhi ^a   Cui, Tao ^b   Zeng, Jumei ^c   Chen, Lulu ^a   Zhang, Wenling ^a   Xu, Xin ^a   Cheng, Lei ^a   Li, Mingyun ^a   Li, Jiyao ^a   Zhou, Xuedong ^a   Li, Yuqing ^a  

^a SICHUAN UNIVERSITY   (China)

^b HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 METHOXYPHENYL) N [3 [[2 (4 METHOXYPHENYL)ETHYL]IMINO] 1,4 DIHYDRO 2 QUINOXALINYLIDENE]ETHANAMINE; ANTIBIOTIC AGENT; BACTERIAL POLYSACCHARIDE; EXTRACELLULAR POLYSACCHARIDE; GLUCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE INHIBITOR; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; MOLECULAR LIBRARY; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL VIRULENCE; BIOFILM; CARBOHYDRATE SYNTHESIS; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENTAL CARIES; DISEASE SEVERITY; DRUG ANTAGONISM; DRUG SCREENING; ENZYME STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOCOCCUS MUTANS; TOOTH PLAQUE; TREATMENT OUTCOME; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER INTERFACE; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; SPRAGUE DAWLEY RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; CRYSTALLOGRAPHY, X-RAY; DENTAL CARIES; DRUG DISCOVERY; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION; GLUCOSYLTRANSFERASES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR DOCKING SIMULATION; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SMALL MOLECULE LIBRARIES; STREPTOCOCCUS MUTANS; USER-COMPUTER INTERFACE; VIRULENCE FACTORS;

EID: 84957865825     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00919-15     Document Type: Article

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