Discoidin domain receptors: Non-integrin collagen receptors on the move

Extracellular Matrix: Pathobiology and Signaling

Volumn , Issue , 2012, Pages 451-466

  Rocca, Antonio S ^a   Bendeck, Michelle P ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84957861617     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (80)

1. Adiguzel, E., Ahmad, P. J., Franco, C., and Bendeck, M. P. (2009). Collagens in the progression and complications of atherosclerosis. Vasc Med 14, 73-89.
2. Ahmad, P. J., Trcka, D., Xue, S., et al. (2009). Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol 175, 2686-2696.
3. Ali, B. R., Xu, H., Akawi, N. A., et al. (2010). Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. Hum Mol Genet 19, 2239-2250.
4. Alves, F., Saupe, S., Ledwon, M., Schaub, F., Hiddemann, W., and Vogel, W. F. (2001). Identification of two novel, kinase-deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines. FASEB J 15, 1321-1323.
5. Avivi-Green, C., Singal, M., and Vogel, W. F. (2006). Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 174, 420-427.
6. Bargal, R., Cormier-Daire, V., and Ben-Neriah, Z., et al. (2009). Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. Am J Hum Genet 84, 80-84.
7. Baumgartner, S., Hofmann, K., Chiquet-Ehrismann, R., and Bucher, P. (1998). The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. Protein Sci 7, 1626-1631.
8. Blay, J. Y., and von Mehren, M. (2011). Nilotinib: a novel, selective tyrosine kinase inhibitor. Semin Oncol 38 (Suppl 1), S3-S9.
9. Castro-Sanchez, L., Soto-Guzman, A., Guaderrama-Diaz, M., Cortes-Reynosa, P., and Salazar, E. (2011). Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells. Clin Exp Metastasis 28, 463-477.
10. Daniels, C. E., Wilkes, M. C., Edens, M., et al. (2004). Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 114, 1308-1316.
11. Day, E., Waters, B., Spiegel, K., et al. (2008). Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib. Eur J Pharmacol 599, 44-53.
12. Eswaramoorthy, R., Wang, C. K., Chen, W. C., et al. (2010). DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation. J Cell Physiol 224, 387-397.
13. Evans, R., Patzak, I., Svensson, L., et al. (2009). Integrins in immunity. J Cell Sci 122, 215-225.
14. Farndale, R. W., Lisman, T., Bihan, D., et al. (2008). Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions. Biochem Soc Trans 36, 241-250.
15. Ferri, N., Carragher, N. O., and Raines, E. W. (2004). Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol 164, 1575-1585.
16. Flamant, M., Placier, S., Rodenas, A., et al. (2006). Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease. J Am Soc Nephrol 17, 3374-3381.
17. Franco, C., Ahmad, P. J., Hou, G., Wong, E., and Bendeck, M. P. (2010). Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1. Circ Res 106, 1775-1783.
18. Franco, C., Britto, K., Wong, E., et al. (2009). Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis. Circ Res 105, 1141-1148.
19. Franco, C., Hou, G., Ahmad, P. J., et al. (2008). Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice. Circ Res 102, 1202-1211.
20. Franco, C. D., Hou, G., and Bendeck, M. P. (2002). Collagens, integrins, and the discoidin domain receptors in arterial occlusive disease. Trends Cardiovasc Med 12, 143-148.
21. Girgert, R., Martin, M., Kruegel, J., et al. (2010). Integrin alpha2-deficient mice provide insights into specific functions of collagen receptors in the kidney. Fibrogenesis Tissue Repair 3, 19.
22. Goldsmith, E. C., Hoffman, A., Morales, M. O., et al. (2004). Organization of fibroblasts in the heart. Dev Dyn 230, 787-794.
23. Gross, O., Beirowski, B., Harvey, S. J., et al. (2004). DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int 66, 102-111.
24. Gross, O., Girgert, R., Beirowski, B., et al. (2010). Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol 29, 346-356.
25. Guerrot, D., Kerroch, M., Placier, S., et al. (2011). Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol 179, 83-91.
26. Hachehouche, L. N., Chetoui, N., and Aoudjit, F. (2010). Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen. Mol Immunol 47, 1866-1869.
27. Hidalgo-Carcedo, C., Hooper, S., Chaudhry, S. I., et al. (2011). Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol 13, 49-58.
28. Hou, G., Vogel, W., and Bendeck, M. P. (2001). The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest 107, 727-735.
29. Hou, G., Vogel, W. F., and Bendeck, M. P. (2002). Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression. Circ Res 90, 1147-1149.
30. Huang, Y., Arora, P., McCulloch, C. A., and Vogel, W. F. (2009). The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. J Cell Sci 122, 1637-1646.
31. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
32. Ikeda, K., Wang, L. H., Torres, R., et al. (2002). Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem 277, 19206-19212.
33. Kamohara, H., Yamashiro, S., Galligan, C., and Yoshimura, T. (2001). Discoidin domain receptor 1 isoform-a (DDR1alpha) promotes migration of leukocytes in three-dimensional collagen lattices. FASEB J 15 (14), 2724-2726.
34. Kato, K., Kanaji, T., Russell, S., et al. (2003). The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 102, 1701-1707.
35. Kim, C., Ye, F., and Ginsberg, M. H. (2010). Regulation of integrin activation. Annu Rev Cell Dev Biol 27, 321-345.
36. Konitsiotis, A. D., Raynal, N., Bihan, D., Hohenester, E., Farndale, R. W., and Leitinger, B. (2008). Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. J Biol Chem 283, 6861-6868.
37. Koo, D. H., McFadden, C., Huang, Y., Abdulhussein, R., Friese-Hamim, M., and Vogel, W. F. (2006). Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1. FEBS Lett 580, 15-22.
38. Labrador, J. P., Azcoitia, V., Tuckermann, J., et al. (2001). The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2, 446-452.
39. Lebbink, R. J., de Ruiter, T., Adelmeijer, J., et al. (2006). Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1. J Exp Med 203, 1419-1425.
40. Lebbink, R. J., Raynal, N., de Ruiter, T., Bihan, D. G., Farndale, R. W., and Meyaard, L. (2009). Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III. Matrix Biol 28, 202-210.
41. Lebbink, R. J., van den Berg, M. C., de Ruiter, T., et al. (2008). The soluble leukocyteassociated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. J Immunol 180, 1662-1669.
42. Lee, R., Eidman, K. E., Kren, S. M., Hostetter, T. H., and Segal, Y. (2004). Localization of discoidin domain receptors in rat kidney. Nephron Exp Nephrol 97, e62-e70.
43. Leitinger, B. (2003). Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. J Biol Chem 278, 16761-16769.
44. Leitinger, B. (2010). Transmembrane collagen receptors. Annu Rev Cell Dev Biol 27, 265-290.
45. Lemarié, C. A., Tharaux, P. L., and Lehoux, S. (2010). Extracellular matrix alterations in hypertensive vascular remodeling. J Mol Cell Cardiol 48, 433-439.
46. Lenting, P. J., Westerlaken, G. H., Denis, C. V., Akkerman, J. W., and Meyaard, L. (2010). Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. PLoS One 5, e12174.
47. Lu, K. K., Trcka, D., and Bendeck, M. P. (2011). Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src. Cardiovasc Pathol 20, 71-76.
48. Manley, P. W., Drueckes, P., Fendrich, G., et al. (2010). Extended kinase profile and properties of the protein kinase inhibitor nilotinib. Biochim Biophys Acta 1804, 445-453.
49. Mihai, C., Chotani, M., Elton, T. S., and Agarwal, G. (2009). Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy. J Mol Biol 385, 432-445.
50. Morales, M. O., Price, R. L., and Goldsmith, E. C. (2005). Expression of discoidin domain receptor 2 (DDR2) in the developing heart. Microsc Microanal 11, 260-267.
51. Moroi, M., and Jung, S. M. (2004). Platelet glycoprotein VI: its structure and function. Thromb Res 114, 221-233.
52. Myllyharju, J., and Kivirikko, K. I. (2004). Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet 20, 33-43.
53. Olaso, E., Ikeda, K., Eng, F. J., et al. (2001). DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest 108, 1369-1378.
54. Orgel, J. P., San Antonio, J. D., and Antipova, O. (2010). Molecular and structural mapping of collagen fibril interactions. Connect Tissue Res 52, 2-17.
55. Patsenker, E., and Stickel, F. (2011). Role of integrins in fibrosing liver diseases. Am J Physiol Gastrointest Liver Physiol 301 (3), G425-G434.
56. Roig, B., Franco-Pons, N., Martorell, L., Tomas, J., Vogel, W. F., and Vilella, E. (2010). Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin. Brain Res 1336, 22-29.
57. Ruggeri, Z. M., and Mendolicchio, G. L. (2007). Adhesion mechanisms in platelet function. Circ Res 100, 1673-1685.
58. Ruiz, P. A., and Jarai, G. (2011). Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts. J Biol Chem 286, 12912-12923.
59. Sakamoto, O., Suga, M., Suda, T., and Ando, M. (2001). Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium. Eur Respir J 17, 969-974.
60. Schoen, F. J. (2008). Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering. Circulation 118, 1864-1880.
61. Shintani, Y., Fukumoto, Y., Chaika, N., Svoboda, R., Wheelock, M. J., and Johnson, K. R. (2008). Collagen 1-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol 180, 1277-1289.
62. Shoulders, M. D., and Raines, R. T. (2009). Collagen structure and stability. Annu Rev Biochem 78, 929-958.
63. Su, J., Yu, J., Ren, T., et al. (2009). Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis. Mol Cell Biochem 330, 141-152.
64. Tomlinson, M. G., Calaminus, S. D., Berlanga, O., et al. (2007). Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines. J Thromb Haemost 5, 2274-2283.
65. Vogel, W., Gish, G. D., Alves, F., and Pawson, T. (1997). The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1, 13-23.
66. Vogel, W. F. (1999). Discoidin domain receptors: structural relations and functional implications. FASEB J 13, 77-82.
67. Vogel, W. F. (2002). Ligand-induced shedding of discoidin domain receptor 1. FEBS Lett 514, 175-180.
68. Vogel, W. F., Abdulhussein, R., and Ford, C. E. (2006). Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal 18, 1108-1116.
69. Vogel, W. F., Aszodi, A., Alves, F., and Pawson, T. (2001). Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol 21, 2906-2917.
70. Wang, C. Z., Su, H. W., Hsu, Y. C., Shen, M. R., and Tang, M. J. (2006). A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha 2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Mol Biol Cell 17, 2839-2852.
71. Wang, C. Z., Yeh, Y. C., and Tang, M. J. (2009). DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. Am J Physiol Cell Physiol 297, C419-C429.
72. Wang, J., Lu, H., Liu, X., et al. (2002). Functional analysis of discoidin domain receptor 2 in synovial fibroblasts in rheumatoid arthritis. J Autoimmun 19, 161-168.
73. Xu, H., Raynal, N., Stathopoulos, S., Myllyharju, J., Farndale, R. W., and Leitinger, B. (2011). Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol 30, 16-26.
74. Xu, L., Servais, J., Polur, I., et al. (2010). Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. Arthritis Rheum 62, 2736-2744.
75. Yang, K., Kim, J. H., Kim, H. J., Park, I. S., Kim, I. Y., and Yang, B. S. (2005). Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. J Biol Chem 280, 39058-39066.
76. Yang, S. H., Baek, H. A., Lee, H. J., et al. (2010). Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung carcinomas. Oncol Rep 24, 311-319.
77. Yeh, Y. C., Wang, C. Z., and Tang, M. J. (2009). Discoidin domain receptor 1 activation suppresses A2B1 integrin-dependent cell spreading through inhibition of Cdc42 activity. J Cell Physiol 218, 146-156.
78. Yeh, Y. C., Wu, C. C., Wang, Y. K., and Tang, M. J. (2011). DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell 22, 940-953.
79. Zhang, Y., Su, J., Yu, J., et al. (2011). An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation. J Bone Miner Res 26, 604-617.
80. Zutter, M. M., and Edelson, B. T. (2007). The A2B1 integrin: a novel collectin/C1q receptor. Immunobiology 212, 343-353.