Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

Cell Stem Cell

Volumn 18, Issue 2, 2016, Pages 253-261

  Lamm, Noa ^a   Ben David, Uri ^a,b   Golan Lev, Tamar ^a   Storchová, Zuzana ^c   Benvenisty, Nissim ^a   Kerem, Batsheva ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

aneuploidy; chromosomal aberrations; condensation perturbations; genomic instability; human pluripotent stem cells; replication stress; SRF

Indexed keywords

ACTIN; SERUM RESPONSE FACTOR;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANAPHASE; ANEUPLOIDY; ARTICLE; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; DIPLOIDY; DNA DAMAGE CHECKPOINT; DNA REPLICATION; DOWN REGULATION; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; METAPHASE CHROMOSOME; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; METAPHASE; PHYSIOLOGICAL STRESS;

ACTIN CYTOSKELETON; ACTINS; ANAPHASE; ANEUPLOIDY; CHROMOSOME ABERRATIONS; CHROMOSOME SEGREGATION; DIPLOIDY; DNA REPLICATION; DOWN-REGULATION; GENOMIC INSTABILITY; HUMANS; METAPHASE; PLURIPOTENT STEM CELLS; SERUM RESPONSE FACTOR; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 84957838297     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.11.003     Document Type: Article

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