Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin

Biochimie

Volumn 122, Issue , 2016, Pages 227-234

  Robertson, Amy L ^a   Headey, Stephen J ^a   Ng, Natasha M ^a   Wijeyewickrema, Lakshmi C ^a,b   Scanlon, Martin J ^a   Pike, Robert N ^a,b   Bottomley, Stephen P ^a  

^a MONASH UNIVERSITY   (Australia)

^b LA TROBE UNIVERSITY   (Australia)

Author keywords

Cleavage; Protease; Protein substrate; Thrombin; helix

Indexed keywords

PROTEIN G; SERINE PROTEINASE; THROMBIN; BACTERIAL PROTEIN; IGG FC-BINDING PROTEIN, STREPTOCOCCUS;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CORRELATION ANALYSIS; ENZYME SUBSTRATE; HUMAN; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN UNFOLDING; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; PROTEOLYSIS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE PROTEASES; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 84957812661     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.09.021     Document Type: Article

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