Antibiotic lock for the prevention of catheter-related infection in neonates

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 6, 2015, Pages

  Taylor, Jacqueline E ^a   Tan, Kenneth ^b   Lai, Nai Ming ^c,d   McDonald, Susan J ^e  

^a MONASH MEDICAL CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MALAYA   (Malaysia)

^d TAYLOR S UNIVERSITY   (Malaysia)

^e MERCY HOSPITAL FOR WOMEN   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PLACEBO; AMOXICILLIN; ANTIINFECTIVE AGENT; FLUCONAZOLE; GENTAMICIN; VANCOMYCIN;

ADVERSE EVENT; ANTIBIOTIC LOCK; ANTIBIOTIC RESISTANCE; CATHETER INFECTION; CAUSE OF DEATH; CLINICAL EFFECTIVENESS; CLINICAL OUTCOME; COMPARATIVE STUDY; DRUG BLOOD LEVEL; GESTATIONAL AGE; HUMAN; HYPOGLYCEMIA; INFANT; META ANALYSIS; NEWBORN; NEWBORN INFECTION; NEWBORN MORTALITY; PRIORITY JOURNAL; QUASI EXPERIMENTAL STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEPSIS; SYSTEMATIC REVIEW; ADVERSE EFFECTS; CATHETER-RELATED INFECTIONS; CENTRAL VENOUS CATHETER; CENTRAL VENOUS CATHETERIZATION; CONFIDENCE INTERVAL; NEWBORN INTENSIVE CARE; PROCEDURES; SELECTION BIAS;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CENTRAL VENOUS CATHETERS; CONFIDENCE INTERVALS; FLUCONAZOLE; GENTAMICINS; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SELECTION BIAS; VANCOMYCIN;

EID: 84957793425     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD010336.pub2     Document Type: Review

References (61)

1. Filippi L, Pezzati M, Di Amario S, Poggi C, Pecile P. Fusidic acid and heparin lock solution for the prevention of catheter-related bloodstream infections in critically ill neonates: a retrospective study and a prospective, randomized trial. Pediatric Critical Care Medicine 2007;8(6):556-62.
2. Garland JS, Alex CP, Henrickson KJ, McAuliffe TL, Maki DG. A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trial. Pediatrics 2005;116(2):e198-205.
3. Seliem W, Abdel-Hady H, El-Nady G. Amikacin-heparin lock for prevention of catheter-related bloodstream infection in neonates with extended umbilical venous catheters use: a randomized controlled trial. Journal of Neonatal-Perinatal Medicine 2010;3(1):33-41.
4. Bertini G, Ceciarini F, Benuzzi A, Elia S, Dani C, Rubaltelli FF. A fusidic-heparin lock solution and silver coated central venous catheters in preventing staphylococcus catheter-related bloodstream infections in VLBW infants. Proceedings of the Society of Pediatric Research Annual Meeting; 2008 2-6 May 2008; Honolulu, Hawaii. 2008.
5. Graham A, Finer NN. Vancomycin flush technique to prevent coagulase negative staphylococcus infection in VLBW infants: a prospective placebo-controlled randomized trial. Proceedings of the Society of Pediatric Research Annual Meeting; Seattle, WA. 3-6 May, 2003.
6. Fort AE, Cummings JJ. A prospective, randomized, blinded, placebo-controlled trial of periodic, brief ethanol locks to prevent peripherally inserted central catheter (PICC) infections in preterm infants in the neonatal intensive care unit. Journal of Investigative Medicine 2011;59:421-2.
7. PREVAIL study - PREVenting infection using Antimicrobial Impregnated Long lines. Ongoing study The study will run from December 2014 to August 2017.
8. Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Current Opinion in Infectious Diseases 2006;19(3):290-7.
9. Ball PA. Intravenous in-line filters: filtering the evidence. Current Opinion in Clinical Nutrition and Metabolic Care 2003;6(3):319-25.
10. Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS, Robertson CM, et al. Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection. Pediatrics 2009;123(1):313-8.
11. Borghesi A, Stronati M. Strategies for the prevention of hospital-acquired infections in the neonatal intensive care unit. Journal of Hospital Infection 2008;68(4):293-300.
12. Carratalà J. The antibiotic-lock technique for therapy of 'highly needed' infected catheters. Clinical Microbiology and Infection 2002;8(5):282-9.
13. Cartwright DW. Central venous lines in neonates: a study of 2186 catheters. Archives of Disease in Childhood. Fetal and Neonatal Edition 2004;89(6):F504-8.
14. Chapman RL, Faix RG. Persistent bacteremia and outcome in late onset infection among infants in a neonatal intensive care unit. Pediatric Infectious Disease Journal 2003;22(1):17-21.
15. Chien LY, Macnab Y, Aziz K, Andrews W, McMillan DD, Lee SK. Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units. Pediatric Infectious Disease Journal 2002;21(6):505-11.
16. Cicalini S, Palmieri F, Petrosillo N. Clinical review: new technologies for prevention of intravascular catheter-related infections. Critical Care 2004;8(3):157-62.
17. de Brito CS, de Brito DV, Abdallah, VO, Gontijo Filho PP. Occurrence of bloodstream infection with different types of central catheter in critically neonates. Journal of Infection 2010;60(2):128-32.
18. Dudeck MA, Horan TC, Peterson KD, Allen-Bridson K, Morrell G, Pollock DA, et al. National Healthcare Safety Network (NHSN) report, data summary for 2010, device-associated module. American Journal of Infection Control 2011;39(10):798-816.
19. Garland JS, Alex CP, Sevallius JM, Murphy DM, Good MJ, Volberding AM, et al. Cohort study of the pathogenesis and molecular epidemiology of catheter-related bloodstream infection in neonates with peripherally inserted central venous catheters. Infection Control and Hospital Epidemiology 2008;29(3):243-9.
20. Jan Brozek, Andrew Oxman, Holger Schünemann. GRADEpro [Version 3.2 for Windows]. The GRADE Working Group, 2008.
21. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology 2011;64(4):383-94. [PUBMED: 21195583]
22. Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, et al. GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). Journal of Clinical Epidemiology 2011;64(4):407-15. [PUBMED: 21247734]
23. Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, et al. GRADE guidelines 6. Rating the quality of evidence--imprecision. Journal of Clinical Epidemiology 2011;64(12):1283-93. [PUBMED: 21839614]
24. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines: 7. Rating the quality of evidence - inconsistency. Journal of Clinical Epidemiology 2011;64(12):1294-302. [PUBMED: 21803546]
25. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines: 8. Rating the quality of evidence - indirectness. Journal of Clinical Epidemiology 2011;64(12):1303-10. [PUBMED: 21802903]
26. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Chichester: John Wiley & Sons Ltd.
27. Hoang V, Sills J, Chandler M, Busalani E, Clifton-Koeppel R, Modanlou HD. Percutaneously inserted central catheter for total parenteral nutrition in neonates: complications rates related to upper versus lower extremity insertion. Pediatrics 2008;121(5):e1152-9.
28. Horan TC, Andrus M, Dudeck, MA CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. American Journal of Infection Control 2008;36(5):309-32.
29. Jaffer Y, Selby NM, Taal MW, Fluck RJ, McIntyre CW. A meta-analysis of hemodialysis catheter locking solutions in the prevention of catheter-related infection. American Journal of Kidney Diseases 2008;51(2):233-41.
30. Kaplan HC, Lannon C, Walsh MC, Donovan EF, Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics 2011;127(3):427-35.
31. Labriola L, Crott R, Jadoul M. Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: a meta-analysis of prospective randomized trials. Nephrology, Dialysis, Transplantation 2008;23(5):1666-72.
32. Lee SK, Aziz K, Singhal N, Cronin CM, James A, Lee DS, et al. Improving the quality of care for infants: a cluster, randomized controlled trial. CMAJ 2009;181(8):469-76. [PUBMED: 19667033]
33. Loisel DB, Smith MM, MacDonald MG, Martin GR. Intravenous access in newborn infants: impact of extending umbilical venous catheter use on requirement for peripheral venous line. Journal of Perinatology 1996;16(6):461-6.
34. Machado JD, Suen VM, Figueiredo JF, Marchini JS. Biofilms, infection, and parenteral nutrition therapy. Journal Parenteral and Enteral Nutrition 2009;33(4):397-403.
35. Mermel LA, Farr BM, Sherertz RJ, Raad II, O'Grady N, Harris JS, et al. Guidelines for the management of intravascular catheter-related infections. Clinical Infectious Diseases 2001;32(9):1249-72.
36. Messing B, Peitra-Cohen S, Debure A, Beliah M, Bernier JJ. Antibiotic-lock technique: a new approach to optimal therapy for catheter-related sepsis in home-parenteral nutrition patients. Journal of Parenteral and Enteral Nutrition 1988;12(2):185-9.
37. Miller MR, Griswold M, Harris JM 2nd, Yenokyan G, Huskins WC, Moss M, et al. Decreasing PICU catheter-associated bloodstream infections: NACHRI's quality transformation efforts. Pediatrics 2010;125(2):206-13.
38. National Healthcare Safety Network (NHSN). Central Line-Associated Bloodstream Infection (CLABSI), 2011. www.cdc.gov/nhsn/pdfs/pscmanual/4psc_clabscurrent.pdf. (accessed 4 December 2012).
39. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, et al. Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disease Control and Prevention, U.S. Pediatrics 2002;110(5):e51.
40. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Centre for Disease Control and Prevention (CDC). Guidelines for the prevention of Intravascular catheter-related infections, 2011. www.cdc.gov/hicpac/bsi/bsi-guidelines-2011.html. (accessed 4 December 2012).
41. Ohki Y, Yoshizawa Y, Watanabe M, Kuwashima M, Morikawa A. Complications of percutaneously inserted central venous catheters in Japanese neonates. Pediatrics International 2008;50(5):636-9.
42. Olsen AL, Reinholdt J, Jensen AM, Andersen LP, Jensen ET. Nosocomial infection in a Danish neonatal intensive care unit: a prospective study. Acta Paediatrica 2009;98(8):1294-9.
43. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. New England Journal of Medicine 2006;355(26):2725-32.
44. Raad I, Costerton W, Sabharwal U, Sacilowski M, Anaissie E, Bodey GP. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. Journal of Infectious Diseases 1993;168(2):400-7.
45. Ramirez de Arellano E, Pascual A, Martinez-Martinez L, Perea EJ. Activity of eight antibacterial agents on staphylococcus epidermidis attached to Teflon catheters. Journal of Medical Microbiology 1994;40(1):43-7.
46. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
47. Rosett W, Hodges GR. Antimicrobial activity of heparin. Journal of Clinical Microbiology 1980;11(1):30-4.
48. Ryder, MA Catheter-related infections: it's all about biofilm. Topics in Advanced Practice Nursing eJournal 2005; Vol. 5.
49. Safdar N, Maki DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trials. Clinical Infectious Diseases 2006;43(4):474-84.
50. Saint S, Veenstra DL, Lipsky BA. The clinical and economic consequences of nosocomial central venous catheter-related infection: are antimicrobial catheters useful?. Infection Control and Hospital Epidemiology 2000;21(6):375-80.
51. Sannoh S, Clones B, Munoz J, Montecalvo M, Parvez B. A multimodal approach to central venous catheter hub care can decrease catheter-related bloodstream infection. American Journal Infection Control 2010;38(6):424-9.
52. Schulman J, Stricof R, Stevens TP, Horgan M, Gase K, Holzman IR, et al. Statewide NICU central-line-associated bloodstream infection rates decline after bundles and checklists. Pediatrics 2011;127(3):436-44.
53. Sengupta A, Lehmann C, Diener-West M, Perl T, Milstone A. Catheter duration and risk of CLA-BSI in neonates with PICCs. Pediatrics 2010;125(4):648-53.
54. Snaterse M, Ruger W, Scholte op Reimer WJM, Lucas C. Antibiotic-based catheter lock solutions for prevention of catheter-related bloodstream infection: a systematic review of randomised controlled trials. Journal of Hospital Infection 2010;75(1):1-11.
55. van de Wetering MD, van Woensel JB. Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD003295.pub2]
56. van der Zwet WC, Kaiser AM, van Elburg RM, Berkhof J, Fetter WP, Parlevliet GA, et al. Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates. Journal of Hospital Infection 2005;61(4):300-11.
57. Vanholder R, Canaud B, Fluck R, Jadoul M, Labriola L, Marti-Monros A, et al. Catheter-related blood stream infections (CRBSI): a European view. Nephrology, Dialysis, Transplantation 2010;25(6):1753-6.
58. Wales PW, Kosar C, Carricato M, de Silva N, Lang K, Avitzur Y. Ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients with intestinal failure: preliminary experience. Journal of Pediatric Surgery 2011;46(5):951-6. [PUBMED: 21616259]
59. Wirtschafter DD, Pettit J, Kurtin P, Dalsey M, Chance K, Morrow HW, et al. A statewide quality improvement collaborative to reduce neonatal central line-associated blood stream infections. Journal of Perinatology 2010;30(3):170-81.
60. Yahav D, Rozen-Zvi B, Gafter-Gvili A, Leibovici L, Gafter U, Paul M. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. Clinical Infectious Diseases 2008;47:83-93.
61. Yebenes JC, Vidaur L, Serra-Prat M, Sirvent JM, Batlle J, Motje M, et al. Prevention of catheter related blood stream infection in critically ill patients using a disinfectable, needle free connector: a randomised controlled trial. American Journal of Infection Control 2004;32(5):291-5.