Ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients with intestinal failure: Preliminary experience

Journal of Pediatric Surgery

Volumn 46, Issue 5, 2011, Pages 951-956

  Wales, Paul W ^a   Kosar, Christina ^a   Carricato, Megan ^a   De Silva, Nicole ^a   Lang, Karen ^a   Avitzur, Yaron ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Catheter related blood stream infection; Central venous catheter; Intestinal failure; Parenteral nutrition; Pediatrics; Short bowel syndrome

Indexed keywords

ALCOHOL; BILIRUBIN; ETHANOL LOCK; UNCLASSIFIED DRUG;

BILIRUBIN BLOOD LEVEL; CATHETER INFECTION; CATHETER REMOVAL; CATHETER THROMBOSIS; CENTRAL VENOUS CATHETER; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; ENTEROPATHY; ETHANOL LOCK THERAPY; FEMALE; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOME CARE; HUMAN; INCIDENCE; INFANT; INFECTION RATE; MALE; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPHYLAXIS;

ANTI-INFECTIVE AGENTS, LOCAL; BACTEREMIA; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; CHILD; CHILD, PRESCHOOL; ETHANOL; FEMALE; FUNGEMIA; HUMANS; INFANT; MALABSORPTION SYNDROMES; MALE; ONTARIO; PARENTERAL NUTRITION, HOME; RETROSPECTIVE STUDIES; SHORT BOWEL SYNDROME;

EID: 79957547477     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2011.02.036     Document Type: Conference Paper

References (31)

1. Beath S, Pironi L, Gabe S, et al. Collaborative strategies to reduce mortality and morbidity in patients with chronic intestinal failure including those who are referred for small bowel transplantation. Transplantation 2008;85:1378-84.
2. Wales PW, de Silva N, Kim JH, et al. Neonatal short bowel syndrome: a cohort study. J Pediatr Surg 2005;40:755-62. (Pubitemid 40724842)
3. Kaufman SS, Atkinson JB, Bianchi A, et al. Indications for pediatric intestinal transplantation: a position paper of the American Society of Transplantation. Pediatr Transplant 2001;5:80-7. (Pubitemid 32298566)
4. Diamond IR, de Silva N, Pencharz PB, et al. Neonatal short bowel syndrome outcomes after the establishment of the first Canadian multidisciplinary intestinal rehabilitation program: preliminary experience. J Pediatr Surg 2007;42:806-11. (Pubitemid 46719214)
5. Mouw E, Chessman K, Lesher A, et al. Use of an ethanol lock to prevent catheter-related infections in children with short bowel syndrome. J Pediatr Surg 2008;43:1025-9. (Pubitemid 351814902)
6. Casey L, Lee KH, Rosychuk R, et al. 10-year review of pediatric intestinal failure: clinical factors associated with outcome. Nutr Clin Pract 2008;23:436-42.
7. Koletzko B, Goulet O, Hunt J, et al. Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 2005;41(Suppl 2):S1-87.
8. Sanders J, Pithie A, Ganly P, et al. A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother 2008;62:809-15.
9. Opilla MT, Kirby DF, Edmond MB. Use of ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients. JPEM JPEM J Parenter Enteral Nutr 2007;31:302-5. (Pubitemid 47025693)
10. Metcalf SC, Chambers ST, Pithie AD. Use of ethanol locks to prevent recurrent central line sepsis. J Infect 2004;49:20-2. (Pubitemid 38950243)
11. Dannenberg C, Bierbach U, Rothe A, et al. Ethanol-lock technique in the treatment of bloodstream infections in pediatric oncology patients with broviac catheter. J Pediatr Hematol Oncol 2003;25:616-21. (Pubitemid 36959422)
12. Onland W, Shin CE, Fustar S, et al. Ethanol-lock technique for persistent bacteremia of long-term intravascular devices in pediatric patients. Arch Pediatr Adolesc Med 2006;160:1049-53. (Pubitemid 44520635)
13. Struijs MC, Diamond IR, de Silva NT, et al. Establishing norms for intestinal length in children. J Pediatr Surg 2009;44:933-8.
14. Diamond IR, de Silva N, Tomlinson G, et al. The role of parenteral lipids in the development of a serum conjugated bilirubin exceeding 100 umol/L in infants on parenteral nutrition - a multiple variable analysis. JPEM JPEM J Parenter Enteral Nutr 2011 [in press].
15. Goulet OJ, Revillon Y, Jan D, et al. Neonatal short bowel syndrome. J Pediatr 1991;119(1) (Pt 1):18-23.
16. O'Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. The hospital infection control practices advisory committee, center for disease control and prevention, U.S. Pediatrics 2002;110:e51.
17. Segarra-Newnham M, Martin-Cooper EM. Antibiotic lock technique: a review of the literature. Ann Pharmacother 2005;39:311-8. (Pubitemid 40165222)
18. Lee OK, Johnston L. A systematic review for effective management of central venous catheters and catheter sites in acute care paediatric patients. Worldviews Evid Based Nurs 2005;2:4-15.
19. Broom J, Woods M, Allworth A, et al. Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: results from a prospective trial. Scand J Infect Dis 2008;40:399-406. (Pubitemid 351566567)
20. Simon A, Ammann RA, Wiszniewsky G, et al. Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infect Dis 2008;29:102.
21. Chambers ST, Peddie B, Pithie A. Ethanol disinfection of plastic-adherent micro-organisms. J Hosp Infect 2006;63:193-6.
22. Sissons CH, Wong L, Cutress TW. Inhibition by ethanol of the growth of biofilm and dispersed microcosm dental plaques. Arch Oral Biol 1996;41:27-34. (Pubitemid 126689925)
23. Sherertz RJ, Boger MS, Collins CA, et al. Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother 2006;50:1865-8.
24. Pennington CR, Pithie AD. Ethanol lock in the management of catheter occlusion. JPEM JPEM J Parenter Enteral Nutr 1987;11:507-8. (Pubitemid 18015445)
25. Johnston DA, Walker K, Richards J, et al. Ethanol flush for the prevention of catheter occlusion. Clin Nutr 1992;11:97-100.
26. Crnich CJ, Halfmann JA, Crone WC, et al. The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular access. Infect Control Hosp Epidemiol 2005;26:708-14. (Pubitemid 41169741)
27. Wong GA, Armstrong DC, Robertson JM. Cardiovascular collapse during ethanol sclerotherapy in a pediatric patient. Paediatr Anaesth 2006;16:343-6.
28. Burrows PE, Mason KP. Percutaneous treatment of low flow vascular malformations. J Vasc Interv Radiol 2004;15:431-45. (Pubitemid 38590866)
29. Hammer FD, Boon LM, Mathurin P, et al. Ethanol sclerotherapy of venous malformations: evaluation of systemic ethanol contamination. J Vasc Interv Radiol 2001;12:595-600. (Pubitemid 32423070)
30. Siepler J. Principles and strategies for monitoring home parenteral nutrition. Nutr Clin Pract 2007;22:340-50.
31. Jones BA, Hull MA, Richardson DS, et al. Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure. J Pediatr Surg 2010;45:1287-93.