Metformin versus insulin in gestational diabetes mellitus: a meta-analysis of randomized clinical trials

Irish Journal of Medical Science

Volumn 185, Issue 2, 2016, Pages 371-381

  Zhu, B ^a   Zhang, L ^b   Fan, Y Y ^c   Wang, L ^d   Li, X G ^a   Liu, T ^a   Cao, Y S ^e   Zhao, Z G ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d BEIJING UNIVERSITY OF CHINESE MEDICINE THIRD AFFILIATED HOSPITAL   (China)

^e BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Gestational diabetes mellitus; Insulin; Metformin; Randomized control trials

Indexed keywords

HEMOGLOBIN A1C; INSULIN; METFORMIN;

ARTICLE; BUDD CHIARI SYNDROME; CESAREAN SECTION; FEMALE; GASTROINTESTINAL SYMPTOM; HOSPITAL ADMISSION; HUMAN; HYPERBILIRUBINEMIA; HYPOGLYCEMIA; INSULIN TREATMENT; JADAD SCORE; LARGE FOR GESTATIONAL AGE; LIFESTYLE MODIFICATION; MACROSOMIA; MATERNAL AGE; META ANALYSIS; NEWBORN DEATH; NEWBORN INTENSIVE CARE; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PREMATURITY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY DISTRESS SYNDROME; SCORING SYSTEM; SEPSIS; SMALL FOR DATE INFANT; UMBILICAL CORD COMPLICATION; WEIGHT GAIN; BIRTH WEIGHT; COMPARATIVE STUDY; DIABETES, GESTATIONAL; GESTATIONAL AGE; NEWBORN; PRE-ECLAMPSIA; PREGNANCY;

BIRTH WEIGHT; CESAREAN SECTION; DIABETES, GESTATIONAL; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INSULIN; METFORMIN; PRE-ECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84957703040     PISSN: 00211265     EISSN: 18634362     Source Type: Journal    
DOI: 10.1007/s11845-016-1414-x     Document Type: Article

References (34)

1. Brewster S, Zinman B, Retnakaran R et al (2013) Cardiometabolic consequences of gestational dysglycemia. J Am Coll Cardiol 62:677–684
2. Ruchat SM, Mottola MF (2013) The important role of physical activity in the prevention and management of gestational diabetes mellitus. Diabetes Metab Res Rev 29:334–346
3. Hirst JE, Tran TS, Do MA et al (2012) Women with gestational diabetes in Vietnam: a qualitative study to determine attitudes and health behaviours. BMC Pregnancy Childbirth 12:81
4. Buchanan TA, Xiang AH, Page KA (2012) Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8:639–649
5. Cheng YW, Caughey AB (2008) Gestational diabetes: diagnosis and management. J Perinatol 28:657–664
6. You JY, Choi SJ, Roh CR et al (2015) Pregnancy and neonatal outcomes in gestational diabetes treated with regular insulin or fast-acting insulin analogues. Gynecol Obstet Invest
7. Simmons D (2010) Metformin treatment for Type 2 diabetes in pregnancy? Best Pract Res Clin Endocrinol Metab 24:625–634
8. Rowan JA, Hague WM, Gao W et al (2008) Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 358:2003–2015
9. Rowan JA, Gao W, Hague WM et al (2010) Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial. Diabetes Care 33:9–16
10. Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12
11. Bhardwaj S, Coleman CI, Sobieraj DM (2012) Efficacy of statins in combination with interferon therapy in multiple sclerosis: a meta-analysis. Am J Health Syst Pharm 69:1494–1499
12. Zhou X, Zhang C, Wu J et al (2013) Association between Helicobacter pylori infection and diabetes mellitus: a meta-analysis of observational studies. Diabetes Res Clin Pract 99:200–208
13. Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560
14. Tertti K, Ekblad U, Vahlberg T et al (2008) Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective, case-control study. Rev Diabet Stud 5:95–101
15. Gandhi P, Bustani R, Madhuvrata P et al (2012) Introduction of metformin for gestational diabetes mellitus in clinical practice: has it had an impact? Eur J Obstet Gynecol Reprod Biol 160:147–150
16. Reece SW, Parihar HS, LoBello C (2014) Metformin in gestational diabetes mellitus. Diabetes Spectr 27:289–295
17. Goh JE, Sadler L, Rowan J (2011) Metformin for gestational diabetes in routine clinical practice. Diabet Med 28:1082–1087
18. Singh KP, Rahimpanah F, Barclay M (2015) Metformin for the management of gestational diabetes mellitus. Aust N Z J Obstet Gynaecol 55:303–308
19. Nicholson W, Bolen S, Witkop CT et al (2009) Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review. Obstet Gynecol 113:193–205
20. Pernicova I, Prasai MJ, Close EJ et al (2011) Could there be a role for metformin in type 1 and type 2 diabetic pregnancies? Diabetologia 54:2466–2467
21. Gui J, Liu Q, Feng L (2013) Metformin vs insulin in the management of gestational diabetes: a meta-analysis. PLoS One 8:e64585
22. Balani J, Hyer SL, Rodin DA et al (2009) Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. Diabet Med 26:798–802
23. Lehnen H, Zechner U, Haaf T (2013) Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life. Mol Hum Reprod 19:415–422
24. Ehrlich SF, Rosas LG, Ferrara A et al (2013) Pregnancy glycemia in Mexican–American women without diabetes or gestational diabetes and programming for childhood obesity. Am J Epidemiol 177:768–775
25. Rowan JA, Rush EC, Obolonkin V et al (2011) Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes Care 34:2279–2284
26. Shah PS, Zao J, Al-Wassia H et al (2011) Pregnancy and neonatal outcomes of aboriginal women: a systematic review and meta-analysis. Womens Health Issues 21:28–39
27. Reece EA, Moore T (2013) The diagnostic criteria for gestational diabetes: to change or not to change? Am J Obstet Gynecol 208:255–259
28. Spaulonci CP, Bernardes LS, Trindade TC et al (2013) Randomized trial of metformin vs insulin in the management of gestational diabetes. Am J Obstet Gynecol 209:31–34
29. Mesdaghinia E, Samimi M, Homaei Z et al (2013) Comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomised blinded trial. Int J Prev Med 4:327–333
30. Tertti K, Ekblad U, Koskinen P et al (2013) Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. Diabetes Obes Metab 15:246–251
31. Niromanesh S, Alavi A, Sharbaf FR et al (2012) Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial. Diabetes Res Clin Pract 98:422–429
32. Hassan JA, Karim N, Sheikh Z (2012) Metformin prevents macrosomia and neonatal morbidity in gestational diabetes. Pak. J. Med. Sci. 28:384–389
33. Ijas H, Vaarasmaki M, Morin-Papunen L et al (2011) Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study. BJOG 118:880–885
34. Moore LE, Briery CM, Clokey D et al (2007) Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. J Reprod Med 52:1011–1015