Metformin compared with insulin in the management of gestational diabetes mellitus: A randomized clinical trial

Diabetes Research and Clinical Practice

Volumn 98, Issue 3, 2012, Pages 422-429

  Niromanesh, Shirin ^a   Alavi, Azin ^b   Sharbaf, Fatemeh Rahimi ^a   Amjadi, Nooshin ^a   Moosavi, Sanaz ^a   Akbari, Soheila ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gestational diabetes mellitus; Insulin; Metformin

Indexed keywords

GLUCOSE; ISOPHANE INSULIN; METFORMIN;

ADULT; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DIET THERAPY; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFECT; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; MAJOR CLINICAL STUDY; NEWBORN MORBIDITY; POSTPRANDIAL STATE; PREGNANCY COMPLICATION; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; WEIGHT GAIN;

ADULT; BIRTH WEIGHT; BLOOD GLUCOSE; DIABETES, GESTATIONAL; DRUG THERAPY, COMBINATION; FEMALE; FETAL MACROSOMIA; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN, ISOPHANE; LOST TO FOLLOW-UP; METFORMIN; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, SECOND; PREGNANCY TRIMESTER, THIRD; SINGLE-BLIND METHOD; WEIGHT GAIN;

EID: 84870718783     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.09.031     Document Type: Article

References (21)

1. Association AD Gestational diabetes mellitus. Diabetes Care 2003, 26:S103-S105.
2. Keshavarz M., Cheung N.W., Babaee G.R., Moghadam H.K., Ajami M.E., Shariati M. Gestational diabetes in Iran: incidence, risk factors and pregnancy outcomes. Diabetes Res Clin Pract 2005, 69:279-286.
3. Korucuoglu U., Biri A., Turkyilmaz E., Doga Yildirim F., Ilhan M., Hirfanoglu I.M., et al. Glycemic levels with glucose loading test during pregnancy and its association with maternal and perinatal outcomes. Diabetes Res Clin Pract 2008, 80:69-74.
4. Metzger B.E., Lowe L.P., Dyer A.R., Trimble E.R., Chaovarindr U., Coustan D.R., et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008, 358:1991-2002.
5. Contreras M., Sacks D., Bowling F., Cowley D., Liley H., McIntyre H., et al. The hyperglycemia and adverse pregnancy outcome (HAPO) study. Int J Gynaecol Obstet 2011, 78:69-77.
6. Rowan J.A., Gao W., Hague W.M., McIntyre H.D. Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial. Diabetes Care 2010, 33:9-16.
7. ACOG Practice Bulletin Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes. Obstet Gynecol 2001, 98:525-538.
8. The American Diabetes Association (ADA) has been actively involved in the development and dissemination of diabetes care standards, guidelines, and related documents for many years. Introduction. Diabetes Care 2009, 32(Suppl. 1):S1-S2.
9. Nicholson W., Baptiste-Roberts K. Oral hypoglycaemic agents during pregnancy: the evidence for effectiveness and safety. Best Pract Res Clin Obstet Gynaecol 2011, 25:51-63.
10. Homko C.J., Reece E.A. Insulins and oral hypoglycemic agents in pregnancy. J Matern Fetal Neonatal Med 2006, 19:679-686.
11. Wensel T.M. Role of metformin in the treatment of gestational diabetes. Ann Pharmacother 2009, 43:939-943.
12. Gilbert C., Valois M., Koren G. Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis. Fertil Steril 2006, 86:658-663.
13. Nicholson W., Bolen S., Witkop C.T., Neale D., Wilson L., Bass E. Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review. Obstet Gynecol 2009, 113:193-205.
14. Nanovskaya T.N., Nekhayeva I.A., Patrikeeva S.L., Hankins G.D.V., Ahmed M.S. Transfer of metformin across the dually perfused human placental lobule. Am J Obstet Gynecol 2006, 195:1081-1085.
15. Coustan D.R., Carpenter M. The diagnosis of gestational diabetes. Diabetes Care 1998, 21:B5-B8.
16. Kim C. Gestational diabetes: risks, management, and treatment options. Int J Womens Health 2010, 2:339-351.
17. Rowan J.A., Hague W.M., Gao W., Battin M.R., Moore M.P. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008, 358:2003-2015.
18. Balani J., Hyer S., Rodin D., Shehata H. Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. Diabet Med 2009, 26:798-802.
19. Tertti K., Ekblad U., Vahlberg T., Rönnemaa T. Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective, case-control study. Rev Diabet Stud 2008, 5:95-101.
20. Hellmuth E., Molsted-Pedersen D.P.L. Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabet Med 2000, 17:507-511.
21. Rai L., Meenakshi D., Kamath A. Metformin-A convenient alternative to insulin for Indian women with diabetes in pregnancy. Indian J Med Sci 2009, 63:491-497.