-
1
-
-
0027109075
-
p53, guardian of the genome
-
COI: 1:STN:280:DyaK38zhtVGmtA%3D%3D, PID: 1614522
-
Lane DP. p53, guardian of the genome. Nature. 1992;358:15–6.
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
2
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
COI: 1:CAS:528:DC%2BC3sXkvFKmtA%3D%3D, PID: 23303139
-
Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013;13:83–96.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
3
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
COI: 1:CAS:528:DyaK3sXkt1ait7g%3D, PID: 8479525
-
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 1993;362:857–60.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
4
-
-
0031194666
-
Isolation and identification of the human homolog of a new p53-binding protein
-
COI: 1:CAS:528:DyaK2sXks1Wksr4%3D, PID: 9226370
-
Shvarts A, Bazuine M, Dekker P, Ramos YF, Steegenga WT, Merckx G, et al. Isolation and identification of the human homolog of a new p53-binding protein. Mdmx Genomics. 1997;43:34–42.
-
(1997)
Mdmx Genomics
, vol.43
, pp. 34-42
-
-
Shvarts, A.1
Bazuine, M.2
Dekker, P.3
Ramos, Y.F.4
Steegenga, W.T.5
Merckx, G.6
-
5
-
-
10144259344
-
MDMX: a novel p53-binding protein with some functional properties of MDM2
-
COI: 1:CAS:528:DyaK28XmsVeiu7c%3D, PID: 8895579
-
Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, et al. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J. 1996;15:5349–57.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
van Laar, T.4
Dekker, P.5
Bazuine, M.6
-
6
-
-
0030860911
-
Repression of p53-mediated transcription by MDM2: a dual mechanism
-
COI: 1:CAS:528:DyaK2sXlsVSmsbY%3D, PID: 9271120
-
Thut CJ, Goodrich JA, Tjian R. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 1997;11:1974–86.
-
(1997)
Genes Dev
, vol.11
, pp. 1974-1986
-
-
Thut, C.J.1
Goodrich, J.A.2
Tjian, R.3
-
7
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
COI: 1:CAS:528:DyaK2sXjtlSgtL8%3D, PID: 9153395
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 1997;387:296–9.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
8
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
COI: 1:CAS:528:DyaK2sXotVyjtrg%3D, PID: 9450543
-
Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 1997;420:25–7.
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
9
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
COI: 1:CAS:528:DyaK2sXjtlSgtLc%3D, PID: 9153396
-
Kubbutat MHG, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature. 1997;387:299–303.
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.G.1
Jones, S.N.2
Vousden, K.H.3
-
10
-
-
34447123808
-
RING domain-mediated interaction is a requirement for MDM2’s E3 ligase activity
-
COI: 1:CAS:528:DC%2BD2sXnsVyqsLk%3D, PID: 17616658
-
Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan ZM. RING domain-mediated interaction is a requirement for MDM2’s E3 ligase activity. Cancer Res. 2007;67:6026–30.
-
(2007)
Cancer Res
, vol.67
, pp. 6026-6030
-
-
Kawai, H.1
Lopez-Pajares, V.2
Kim, M.M.3
Wiederschain, D.4
Yuan, Z.M.5
-
11
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
COI: 1:CAS:528:DC%2BD3sXotlGltLc%3D, PID: 14507994
-
Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A. 2003;100:12009–14.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Muller, S.4
Scheffner, M.5
-
12
-
-
33845270990
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
-
COI: 1:CAS:528:DC%2BD28Xht1Clsr3E, PID: 17128209
-
Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006;6:909–23.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
13
-
-
77956926019
-
Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4
-
COI: 1:CAS:528:DC%2BC3cXhtFGqtrvN, PID: 20736370
-
Xiong S, Pant V, Suh YA, Van Pelt CS, Wang Y, Valentin-Vega YA, et al. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res. 2010;70:7148–54.
-
(2010)
Cancer Res
, vol.70
, pp. 7148-7154
-
-
Xiong, S.1
Pant, V.2
Suh, Y.A.3
Van Pelt, C.S.4
Wang, Y.5
Valentin-Vega, Y.A.6
-
14
-
-
8844278362
-
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
-
COI: 1:CAS:528:DC%2BD2cXhtVGls7bF, PID: 15550242
-
Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 2004;119:591–602.
-
(2004)
Cell
, vol.119
, pp. 591-602
-
-
Bond, G.L.1
Hu, W.2
Bond, E.E.3
Robins, H.4
Lutzker, S.G.5
Arva, N.C.6
-
15
-
-
79751471610
-
The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians
-
COI: 1:CAS:528:DC%2BC3MXhvFektr4%3D, PID: 21316605
-
Knappskog S, Bjornslett M, Myklebust LM, Huijts PE, Vreeswijk MP, Edvardsen H, et al. The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians. Cancer Cell. 2011;19:273–82.
-
(2011)
Cancer Cell
, vol.19
, pp. 273-282
-
-
Knappskog, S.1
Bjornslett, M.2
Myklebust, L.M.3
Huijts, P.E.4
Vreeswijk, M.P.5
Edvardsen, H.6
-
16
-
-
67649841887
-
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
-
COI: 1:CAS:528:DC%2BD1MXot1Gkuro%3D, PID: 19497887
-
Atwal GS, Kirchhoff T, Bond EE, Montagna M, Menin C, Bertorelle R, et al. Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. Proc Natl Acad Sci U S A. 2009;106:10236–41.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10236-10241
-
-
Atwal, G.S.1
Kirchhoff, T.2
Bond, E.E.3
Montagna, M.4
Menin, C.5
Bertorelle, R.6
-
17
-
-
84963564563
-
MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk
-
COI: 1:CAS:528:DC%2BC2MXitVCrtrrM, PID: 26471763
-
Gansmo LB, Romundstad P, Birkeland E, Hveem K, Vatten L, Knappskog S, et al. MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk. Cancer Med. 2015;4:1901–7.
-
(2015)
Cancer Med
, vol.4
, pp. 1901-1907
-
-
Gansmo, L.B.1
Romundstad, P.2
Birkeland, E.3
Hveem, K.4
Vatten, L.5
Knappskog, S.6
-
18
-
-
70849123864
-
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
-
COI: 1:CAS:528:DC%2BD1MXhsV2jtb3P, PID: 19762336
-
Kulkarni DA, Vazquez A, Haffty BG, Bandera EV, Hu W, Sun YY, et al. A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. Carcinogenesis. 2009;30:1910–5.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1910-1915
-
-
Kulkarni, D.A.1
Vazquez, A.2
Haffty, B.G.3
Bandera, E.V.4
Hu, W.5
Sun, Y.Y.6
-
19
-
-
84929315369
-
A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer
-
COI: 1:CAS:528:DC%2BC2MXosFSqs70%3D, PID: 25670033
-
Stegeman S, Moya L, Selth LA, Spurdle AB, Clements JA, Batra J. A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer. Endocr Relat Cancer. 2015;22:265–76.
-
(2015)
Endocr Relat Cancer
, vol.22
, pp. 265-276
-
-
Stegeman, S.1
Moya, L.2
Selth, L.A.3
Spurdle, A.B.4
Clements, J.A.5
Batra, J.6
-
20
-
-
78649965834
-
An illegitimate microRNA target site within the 3′ UTR of MDM4 affects ovarian cancer progression and chemosensitivity
-
COI: 1:CAS:528:DC%2BC3cXhsFamurrM, PID: 21084273
-
Wynendaele J, Bohnke A, Leucci E, Nielsen SJ, Lambertz I, Hammer S, et al. An illegitimate microRNA target site within the 3′ UTR of MDM4 affects ovarian cancer progression and chemosensitivity. Cancer Res. 2010;70:9641–9.
-
(2010)
Cancer Res
, vol.70
, pp. 9641-9649
-
-
Wynendaele, J.1
Bohnke, A.2
Leucci, E.3
Nielsen, S.J.4
Lambertz, I.5
Hammer, S.6
-
21
-
-
84880279385
-
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility
-
COI: 1:CAS:528:DC%2BC3sXhtFajurjF, PID: 23793604
-
Liu J, Tang X, Li M, Lu C, Shi J, Zhou L, et al. Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility. Breast Cancer Res Treat. 2013;140:151–7.
-
(2013)
Breast Cancer Res Treat
, vol.140
, pp. 151-157
-
-
Liu, J.1
Tang, X.2
Li, M.3
Lu, C.4
Shi, J.5
Zhou, L.6
-
22
-
-
84875701351
-
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
-
COI: 1:CAS:528:DC%2BC3sXks1GmtL4%3D, PID: 23535733, 8e1-2
-
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013;45:392–8. 8e1-2.
-
(2013)
Nat Genet
, vol.45
, pp. 392-398
-
-
Garcia-Closas, M.1
Couch, F.J.2
Lindstrom, S.3
Michailidou, K.4
Schmidt, M.K.5
Brook, M.N.6
-
23
-
-
84901988970
-
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
-
COI: 1:CAS:528:DC%2BC2cXntlyls7c%3D, PID: 24325915
-
Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, et al. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis. 2014;35:1012–9.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1012-1019
-
-
Purrington, K.S.1
Slager, S.2
Eccles, D.3
Yannoukakos, D.4
Fasching, P.A.5
Miron, P.6
-
24
-
-
84875993448
-
Genetic susceptibility to triple-negative breast cancer
-
COI: 1:CAS:528:DC%2BC3sXltVOks74%3D, PID: 23536562
-
Stevens KN, Vachon CM, Couch FJ. Genetic susceptibility to triple-negative breast cancer. Cancer Res. 2013;73:2025–30.
-
(2013)
Cancer Res
, vol.73
, pp. 2025-2030
-
-
Stevens, K.N.1
Vachon, C.M.2
Couch, F.J.3
-
25
-
-
84925526055
-
The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to non-Hodgkin lymphoma risk
-
PID: 25203442
-
Fan C, Wei J, Yuan C, Wang X, Jiang C, Zhou C, et al. The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to non-Hodgkin lymphoma risk. PLoS One. 2014;9, e107047.
-
(2014)
PLoS One
, vol.9
-
-
Fan, C.1
Wei, J.2
Yuan, C.3
Wang, X.4
Jiang, C.5
Zhou, C.6
-
26
-
-
84878423182
-
Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BC3sXpsVKktrs%3D, PID: 23724042
-
Zhou L, Zhang X, Li Z, Zhou C, Li M, Tang X, et al. Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma. PLoS One. 2013;8, e64331.
-
(2013)
PLoS One
, vol.8
-
-
Zhou, L.1
Zhang, X.2
Li, Z.3
Zhou, C.4
Li, M.5
Tang, X.6
-
27
-
-
84875739291
-
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
-
COI: 1:CAS:528:DC%2BC3sXks1Gms78%3D, PID: 23535732, 91e1-2
-
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet. 2013;45:385–91. 91e1-2.
-
(2013)
Nat Genet
, vol.45
, pp. 385-391
-
-
Eeles, R.A.1
Olama, A.A.2
Benlloch, S.3
Saunders, E.J.4
Leongamornlert, D.A.5
Tymrakiewicz, M.6
-
28
-
-
84860459353
-
MoMa TECsg et al. SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer
-
COI: 1:CAS:528:DC%2BC38XhtF2ru7bP, PID: 22119201
-
Knappskog S, Trovik J, Marcickiewicz J, Tingulstad S, Staff AC. MoMa TECsg et al. SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer. Eur J Cancer. 2012;48:1988–96.
-
(2012)
Eur J Cancer
, vol.48
, pp. 1988-1996
-
-
Knappskog, S.1
Trovik, J.2
Marcickiewicz, J.3
Tingulstad, S.4
Staff, A.C.5
-
29
-
-
79956000555
-
Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer
-
COI: 1:CAS:528:DC%2BC3MXmtVGit7o%3D, PID: 21242118
-
Trovik J, Wik E, Stefansson IM, Marcickiewicz J, Tingulstad S, Staff AC, et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res. 2011;17:3368–77.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3368-3377
-
-
Trovik, J.1
Wik, E.2
Stefansson, I.M.3
Marcickiewicz, J.4
Tingulstad, S.5
Staff, A.C.6
-
30
-
-
44949262835
-
Cohort profile: cohort of Norway (CONOR)
-
PID: 17984119
-
Naess O, Sogaard AJ, Arnesen E, Beckstrom AC, Bjertness E, Engeland A, et al. Cohort profile: cohort of Norway (CONOR). Int J Epidemiol. 2008;37:481–5.
-
(2008)
Int J Epidemiol
, vol.37
, pp. 481-485
-
-
Naess, O.1
Sogaard, A.J.2
Arnesen, E.3
Beckstrom, A.C.4
Bjertness, E.5
Engeland, A.6
-
31
-
-
2942738959
-
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
-
COI: 1:CAS:528:DC%2BD2cXls1aqtrc%3D, PID: 15199139
-
Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, et al. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol. 2004;24:5835–43.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5835-5843
-
-
Danovi, D.1
Meulmeester, E.2
Pasini, D.3
Migliorini, D.4
Capra, M.5
Frenk, R.6
-
32
-
-
79959838081
-
-
Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609-15.
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
33
-
-
74849083374
-
Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis
-
PID: 19590949
-
Economopoulos KP, Sergentanis TN. Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis. Breast Cancer Res Treat. 2010;120:211–6.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 211-216
-
-
Economopoulos, K.P.1
Sergentanis, T.N.2
-
34
-
-
38849111754
-
MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies
-
COI: 1:CAS:528:DC%2BD2sXhsVenur3J, PID: 18086778
-
Hu Z, Jin G, Wang L, Chen F, Wang X, Shen H. MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies. Cancer Epidemiol Biomarkers Prev. 2007;16:2717–23.
-
(2007)
Cancer Epidemiol. Biomarkers Prev
, vol.16
, pp. 2717-2723
-
-
Hu, Z.1
Jin, G.2
Wang, L.3
Chen, F.4
Wang, X.5
Shen, H.6
-
35
-
-
84877028141
-
-
TCGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
36
-
-
84930413360
-
Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon
-
COI: 1:CAS:528:DC%2BC2cXitVCks7jE, PID: 25431177
-
Gansmo LB, Knappskog S, Romundstad P, Hveem K, Vatten L, Lonning PE. Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon. Int J Cancer. 2015;137:96–103.
-
(2015)
Int J Cancer
, vol.137
, pp. 96-103
-
-
Gansmo, L.B.1
Knappskog, S.2
Romundstad, P.3
Hveem, K.4
Vatten, L.5
Lonning, P.E.6
-
37
-
-
84867076867
-
MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer
-
COI: 1:CAS:528:DC%2BC38XmtFajurw%3D, PID: 22487911
-
Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, et al. MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. Int J Cancer. 2012;131:2710–6.
-
(2012)
Int J Cancer
, vol.131
, pp. 2710-2716
-
-
Ryan, B.M.1
Calhoun, K.M.2
Pine, S.R.3
Bowman, E.D.4
Robles, A.I.5
Ambs, S.6
-
38
-
-
84975795680
-
An integrated map of genetic variation from 1,092 human genomes
-
Genomes Project C, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, et al. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491:56–65.
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
Genomes Project, C.1
Abecasis, G.R.2
Auton, A.3
Brooks, L.D.4
DePristo, M.A.5
Durbin, R.M.6
-
39
-
-
84907998640
-
Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)
-
PID: 25327560
-
Knappskog S, Gansmo LB, Dibirova K, Metspalu A, Cybulski C, Peterlongo P, et al. Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). Oncotarget. 2014;5:8223–34.
-
(2014)
Oncotarget
, vol.5
, pp. 8223-8234
-
-
Knappskog, S.1
Gansmo, L.B.2
Dibirova, K.3
Metspalu, A.4
Cybulski, C.5
Peterlongo, P.6
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