ELK3 expression correlates with cell migration, invasion, and membrane type 1-matrix metalloproteinase expression in MDA-MB-231 breast cancer cells

Gene Expression

Volumn 16, Issue 4, 2015, Pages 197-203

  Heo, Sun Hee ^a   Lee, Je Yong ^a   Yang, Kyung Min ^a   Park, Kyung Soon ^a  

^a CHA University   (South Korea)

Author keywords

Breast cancer; ELK3; Metastasis; MT1 MMP

Indexed keywords

MATRIX METALLOPROTEINASE 14; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ELK 3; TRANSCRIPTION FACTOR ETS; UNCLASSIFIED DRUG; ELK3 PROTEIN, HUMAN; ONCOPROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BASAL CELL; BREAST CANCER; BREAST CANCER CELL LINE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; PROMOTER REGION; UPREGULATION; BREAST TUMOR; FEMALE; METABOLISM; TUMOR CELL LINE; TUMOR INVASION;

BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 14; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 84957665623     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/105221615X14399878166276     Document Type: Article

References (21)

1. Ayadi A, Suelves M, Dolle P, Wasylyk B. Net, an Ets ternary complex transcription factor, is expressed in sites of vasculogenesis, angiogenesis, and chondrogenesis during mouse development. Mech Dev 2001; 102:205-208.
2. Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene 2004; 324:1-14.
3. Ducret C, Maira SM, Lutz Y, Wasylyk B. The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. Oncogene 2000; 19:5063-5072.
4. Zheng H, Wasylyk C, Ayadi A, Abecassis J, Schalken JA, Rogatsch H, et al. The transcription factor Net regulates the angiogenic switch. Genes Dev 2003; 17:2283-2297.
5. Sloan KA, Marquez HA, Li J, Cao Y, Hinds A, O'Hara CJ, et al. Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis 2009; 30:1433-1442.
6. Buchwalter G, Gross C, Wasylyk B. The ternary complex factor Net regulates cell migration through inhibition of PAI-1 expression. Mol Cell Biol 2005; 25:10853-10862.
7. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147:275-292.
8. Koziol A, Martin-Alonso M, Clemente C, Gonzalo P, Arroyo AG. Site-specific cellular functions of MT1-MMP. Eur J Cell Biol 2012; 91:889-895.
9. Deryugina EI, Quigley JP. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006; 25:9-34.
10. Hofmann UB, Eggert AA, Blass K, Brocker EB, Becker JC. Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation. Cancer Res 2003; 63:8221-8225.
11. Annabi B, Rojas-Sutterlin S, Laflamme C, Lachambre MP, Rolland Y, Startelet H, et al. Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype. Mol Cancer Res 2008;6:907-916.
12. Ueno H, Nakamura H, Inoue M, Imai K, Noquchi M, Sato H, et al. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Res 1997; 57:2055-2060.
13. Hotary KB, Yana I, Sabeh F, Li XY, Holmbeck K, Birkedal-Hansen H, et al. Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and-independent processes. J Exp Med 2002; 195:295-308.
14. Jiang A, Lehti K, Wang X, Weiss SJ, Keski-Oja J, Pei D. Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis. Proc Natl Acad Sci USA 2001; 98:13693-13698.
15. Kajita M, Itoh Y, Chiba T, Mori H, Okada A, Kinoh H, et al. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol 2001; 153:893-904.
16. Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Satp H, et al. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J 2002; 21:3949-3959.
17. Izumiyama Y, Ohiro Y, Higashino F, Yoshida K, Taquchi K, Todo S, et al. E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncol Rep 2005; 13:715-720.
18. Sroka IC, Nagle RB, Bowden GT. Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells. Neoplasia 2007; 9:406-417.
19. Heo SH, Cho JY. ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP. Int J Biol Sci 2014; 10:438-447.
20. Heo SH, Choi YJ, Ryoo HM, Cho JY. Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: Role of MMP-10 in VEGF-induced angiogenesis. J Cell Physiol 2010; 224:734-742.
21. Ducret C, Maira SM, Dierich A, Wasylyk B. The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. Mol Cell Biol 1999; 19:7076-7087.