Grass-specific CD4+ T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy

Clinical and Experimental Allergy

Volumn 44, Issue 7, 2014, Pages 986-998

  Archila, L D ^a   Delong, J H ^a   Wambre, E ^a   James, E A ^a   Robinson, D M ^b   Kwok, W W ^a,c  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b VIRGINIA MASON MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Allergy; Cross reactivity; Epitopes; Grass pollen; MHC class II tetramers; Pooideae; T cells

Indexed keywords

ALLOPHYCOCYANIN; EPITOPE; GAMMA INTERFERON; GRASS POLLEN EXTRACT; IMMUNOGLOBULIN E; INTERLEUKIN 4; PHYCOERYTHRIN; TETRAMER; ALLERGEN; CYTOKINE; HLA ANTIGEN; PEPTIDE; PLANT ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; BARLEY; CD4+ T LYMPHOCYTE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; DACTYLIS GLOMERATA; EX VIVO STUDY; HOLCUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOTHERAPY; IN VITRO STUDY; PERENNIAL RYEGRASS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHALARIS; PHLEUM PRATENSE; POA PRATENSIS; POLLEN ALLERGY; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH2 CELL; ALLELE; AMINO ACID SEQUENCE; BASOPHIL; CHEMISTRY; DESENSITIZATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; POACEAE; POLLEN; T LYMPHOCYTE SUBPOPULATION;

ALLELES; ALLERGENS; AMINO ACID SEQUENCE; ANTIGENS, PLANT; BASOPHILS; CD4-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; CYTOKINES; DESENSITIZATION, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN E; LYMPHOCYTE ACTIVATION; PEPTIDES; POACEAE; POLLEN; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS;

EID: 84904624608     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12324     Document Type: Article

References (35)

1. Weber RW. Patterns of pollen cross-allergenicity. J Allergy Clin Immunol 2003; 112:229-39.
2. Weber RW. Cross-reactivity of pollen allergens. Curr Allergy Asthma Rep 2004; 4:401-8.
3. White JF, Bernstein DI. Key pollen allergens in North America. Ann Allergy Asthma Immunol 2003; 91:425-35.
4. Weber RW, Nelson HS. Pollen allergens and their interrelationships. Clin Rev Allergy 1985; 3:291-318.
5. Marcucci F, Sensi L, Di CG et al. Which allergen extract for grass pollen immunotherapy? An in vitro study Immunol Invest 2010; 39:635-44.
6. Jager S. Exposure to grass pollen in Europe. Clin Exp Allergy Rev 2008; 8:2-6.
7. Hrabina M, Peltre G, Van Ree R, Moingeon P. Grass pollen allergens. Clin Exp Allergy Rev 2008; 8:7-11.
8. Andersson K, Lidholm J. Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol 2003; 130:87-107.
9. Martinez-Cocera C, Sastre J, Cimarra M et al. Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract. J Investig Allergol Clin Immunol 2010; 20:13-9.
10. Weber RW. Cross-reactivity of plant and animal allergens. Clin Rev Allergy Immunol 2001; 21:153-202.
11. Hejl C, Wurtzen PA, Kleine-Tebbe J, Johansen N, Broge L, Ipsen H. Phleum pratense alone is sufficient for allergen-specific immunotherapy against allergy to Pooideae grass pollens. Clin Exp Allergy 2009; 39:752-9.
12. + T cells. J Allergy Clin Immunol 2010; 125:1407-9.
13. + T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol 2012; 129:544-51, 551.
14. Schenk S, Breiteneder H, Susani M et al. T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens. J Allergy Clin Immunol 1995; 96:986-96.
15. Muller WD, Karamfilov T, Kahlert H et al. Mapping of T-cell epitopes of Phl p 5: evidence for crossreacting and non-crossreacting T-cell epitopes within Phl p 5 isoallergens. Clin Exp Allergy 1998; 28:1538-48.
16. Burtin D, Chabre H, Olagnier B et al. Production of native and modified recombinant Der p 1 molecules in tobacco plants. Clin Exp Allergy 2009; 39:760-70.
17. Schmidt H, Gelhaus C, Nebendahl M, Janssen O, Petersen A. Characterization of Phleum pratense pollen extracts by 2-D DIGE and allergen immunoreactivity. Proteomics 2010; 10:4352-62.
18. Ge X, Tan V, Bollyky PL, Standifer NE, James EA, Kwok WW. Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus. J Virol 2010; 84:3312-9.
19. + T cell responses in an epitope-dependent manner. J Allergy Clin Immunol 2013; 133:872-9.e7.
20. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990; 215:403-10.
21. Dahl R, Kapp A, Colombo G et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006; 118:434-40.
22. Durham SR, Yang WH, Pedersen MR, Johansen N, Rak S. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006; 117:802-9.
23. Moingeon P, Hrabina M, Bergmann KC et al. Specific immunotherapy for common grass pollen allergies: pertinence of a five grass pollen vaccine. Int Arch Allergy Immunol 2008; 146:338-42.
24. Chabre H, Gouyon B, Huet A et al. Molecular variability of group 1 and 5 grass pollen allergens between Pooideae species: implications for immunotherapy. Clin Exp Allergy 2010; 40:505-19.
25. Didier A, Malling HJ, Worm M et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007; 120:1338-45.
26. Hrabina M, Jain K, Gouyon B. Cross-reactivity between pollen allergens from common Pooideae grasses and rye. Clin Exp Allergy Rev 2008; 8:18-20.
27. Leiferman KM, Gleich GJ. The cross-reactivity of IgE antibodies with pollen allergens. I. Analyses of various species of grass pollens. J Allergy Clin Immunol 1976; 58:129-39.
28. Focke-Tejkl M, Campana R, Reininger R et al. Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5. J Allergy Clin Immunol 2014; 133:836-45.e11.
29. Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity 1997; 7:473-81.
30. Southwood S, Sidney J, Kondo A et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol 1998; 160:3363-73.
31. Yassai M, Afsari A, Garlie J, Gorski J. C-terminal anchoring of a peptide to class II MHC via the P10 residue is compatible with a peptide bulge. J Immunol 2002; 168:1281-5.
32. Sette A, Sidney J, Oseroff C et al. HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions. J Immunol 1993; 151:3163-70.
33. Gabrysova L, Wraith DC. Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells. Eur J Immunol 2010; 40:1386-95.
34. Campbell JD, Buckland KF, McMillan SJ et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009; 206:1535-47.
35. Holan V, Mitchison NA. Haplotype-specific suppressor T cells mediating linked suppression of immune responses elicited by third-party H-2 alloantigens. Eur J Immunol 1983; 13:652-7.